NP_112624.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
98,715 Da
NCBI Official Full Name
cadherin-1
NCBI Official Synonym Full Names
cadherin 1
NCBI Protein Information
cadherin-1
UniProt Protein Name
Cadherin-1
UniProt Synonym Protein Names
Epithelial cadherin; E-cadherin
UniProt Synonym Gene Names
NCBI Summary for E-cad
cell-cell adhesion molecule; may play a role in axonal growth and synase formation [RGD, Feb 2006]
UniProt Comments for E-cad
CDH1: a single-pass type I membrane protein, and calcium dependent cell adhesion proteins. It is a ligand for integrin alpha-E/beta-7, and it colocalizes with DLG7 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Defects in CDH1 are involved in dysfunction of the cell-cell adhesion system, triggering cancer invasion (gastric, breast, ovary, endometrium and thyroid) and metastasis. Has a potent invasive suppressor role.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 19q12
Cellular Component: actin cytoskeleton; adherens junction; apical junction complex; apical part of cell; axon; basolateral plasma membrane; catenin complex; cell junction; cell surface; cell-cell adherens junction; cortical actin cytoskeleton; cytoplasm; flotillin complex; focal adhesion; integral to membrane; intercellular junction; internal side of plasma membrane; lamellipodium; lateral loop; lateral plasma membrane; nerve terminal; perinuclear region of cytoplasm; plasma membrane; trans-Golgi network
Molecular Function: alpha-catenin binding; ankyrin binding; beta-catenin binding; calcium ion binding; cell adhesion molecule binding; cytoskeletal protein binding; gamma-catenin binding; glycoprotein binding; GTPase activating protein binding; protein binding; protein domain specific binding; protein phosphatase binding
Biological Process: calcium-dependent cell-cell adhesion; cell-cell adhesion; decidualization; embryo implantation; in utero embryonic development; negative regulation of cell-cell adhesion; negative regulation of epithelial cell proliferation; neurite development; pituitary gland development; positive regulation of cell-cell adhesion; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein homooligomerization; protein metabolic process; regulation of caspase activity; regulation of protein localization; regulation of water loss via skin; response to drug; response to organic substance; response to toxin; sensory perception of sound; synaptogenesis; trophectodermal cell differentiation
Research Articles on E-cad
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Products associated with E-cad recombinant protein
Pathways associated with E-cad recombinant protein
Diseases associated with E-cad recombinant protein
Organs/Tissues associated with E-cad recombinant protein
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