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SELE recombinant protein :: E-Selectin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142935 SELE recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,625 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

E-Selectin, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human E-Selectin

 Product Synonym Names    E Selectin Human; E-selectin Human Recombinant; E-selectin; Endothelial leukocyte adhesion molecule 1; ELAM-1; Leukocyte-endothelial cell adhesion molecule 2; LECAM2; CD62E antigen; SELE; ELAM1; ELAM; ESEL; CD62E
 Product Gene Name   

SELE recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    131210
 3D Structure    ModBase 3D Structure for P16581
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 Host    E Coli
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 Purity/Purification    Greater than 95% as determined by SDS-PAGE.Single band on Western Blot.
 Form/Format    E-Selectin is supplied in 1x PBS and 50% Glycerol.
Sterile Filtered liquid formulation.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 1-2 weeks. Store, frozen at -20 degree C for longer periods of time. Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of SELE recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SELE recombinant protein

   Description: E-Selectin Human Recombinant is expressed in E Coli containing amino acids 179-557 fused to an amino terminal hexahistidine tag, having a total molecular weight of 45.22 kDa.

Introduction: E-selectin which is also called Endothelial leukocyte adhesion molecule 1, ELAM1, ELAM belongs to a family of divalent cation-dependent carbohydrate-binding glycoproteins or adhesion molecules. Eselectin is expressed on the surface of endothelial cells and mediates the interaction of leukocytes and platelets with endothelial cells during an inflammatory response. E-selectin is present in single copy in the human genome and contains 14 exons spanning about 13 kb of DNA.
 Product Categories/Family for SELE recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Selectin
NCBI/Uniprot data below describe general gene information for SELE. It may not necessarily be applicable to this product.
 NCBI GI #    187960042
 NCBI GeneID    6401
 NCBI Accession #    NP_000441.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000450.2 [Other Products]
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 UniProt Primary Accession #    P16581 [Other Products]
 UniProt Secondary Accession #    P16111; A2RRD6 [Other Products]
 UniProt Related Accession #    P16581 [Other Products]
 Molecular Weight    66,655 Da
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 NCBI Official Full Name    E-selectin
 NCBI Official Synonym Full Names    selectin E
 NCBI Official Symbol    SELE [Similar Products]
 NCBI Official Synonym Symbols   
ELAM; ESEL; CD62E; ELAM1; LECAM2
[Similar Products]
 NCBI Protein Information    E-selectin; CD62 antigen-like family member E; ELAM-1; endothelial adhesion molecule 1; endothelial leukocyte adhesion molecule 1; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2
 UniProt Protein Name    E-selectin
 UniProt Synonym Protein Names   
CD62 antigen-like family member E; Endothelial leukocyte adhesion molecule 1; ELAM-1; Leukocyte-endothelial cell adhesion molecule 2; LECAM2; CD_antigen: CD62E
 Protein Family    E-selectin
 UniProt Gene Name    SELE [Similar Products]
 UniProt Synonym Gene Names    ELAM1; ELAM-1; LECAM2 [Similar Products]
 UniProt Entry Name    LYAM2_HUMAN
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 NCBI Summary for SELE    The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SELE    SELE: Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis. Belongs to the selectin/LECAM family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q22-q25

Cellular Component: cortical cytoskeleton; extracellular space; perinuclear region of cytoplasm; integral to membrane; plasma membrane; coated pit; caveola; lipid raft

Molecular Function: protein binding; phospholipase binding; transmembrane receptor activity; sialic acid binding

Biological Process: positive regulation of leukocyte migration; positive regulation of receptor internalization; actin filament-based process; calcium-mediated signaling; response to lipopolysaccharide; leukocyte migration during inflammatory response; heterophilic cell adhesion; leukocyte adhesion; phospholipase C activation; regulation of inflammatory response; inflammatory response; blood coagulation; leukocyte tethering or rolling; leukocyte migration

Disease: Hypertension, Essential
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 Research Articles on SELE    1. an upregulation of E-selectin and the associated influx of neutrophils may play a significant role in the resolution of inflammation as well as for the pathophysiology of nasal polyps of Caucasian chronic rhinosinusitis patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SELE recombinant proteinPathways associated with SELE recombinant protein
 Reference Product  PubMed Publications
 ICAM1 recombinant protein  >87 publications with SELE and ICAM1
 TNF recombinant protein  >35 publications with SELE and TNF
 JUN recombinant protein  >31 publications with SELE and JUN
 NFKB1 recombinant protein  >3 publications with SELE and NFKB1
 RELA recombinant protein  >3 publications with SELE and RELA
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
Diseases associated with SELE recombinant proteinOrgans/Tissues associated with SELE recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >92 publications with SELE and Inflammation
 Cardiovascular Diseases Antibodies  >87 publications with SELE and Cardiovascular Diseases
 Necrosis Antibodies  >42 publications with SELE and Necrosis
 Atherosclerosis Antibodies  >38 publications with SELE and Atherosclerosis
 Heart Diseases Antibodies  >23 publications with SELE and Heart Diseases
 Lung Diseases Antibodies  >22 publications with SELE and Lung Diseases
 Myocardial Ischemia Antibodies  >22 publications with SELE and Myocardial Ischemia
 Hypertension Antibodies  >17 publications with SELE and Hypertension
 Myocardial Infarction Antibodies  >10 publications with SELE and Myocardial Infarction
 Anemia Antibodies  >6 publications with SELE and Anemia
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >119 publications with SELE and Vascular
 Heart Antibodies  >23 publications with SELE and Heart
 Lung Antibodies  >16 publications with SELE and Lung
 Liver Antibodies  >10 publications with SELE and Liver
 Muscle Antibodies  >10 publications with SELE and Muscle
 Brain Antibodies  >9 publications with SELE and Brain
 Connective Tissue Antibodies  >7 publications with SELE and Connective Tissue
 Testis Antibodies  >6 publications with SELE and Testis
 Uterus Antibodies  >6 publications with SELE and Uterus
 Placenta Antibodies  >3 publications with SELE and Placenta
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