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E1B-55K recombinant protein :: E1B protein, large T-antigen Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1049183 E1B-55K recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $850 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,075 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,135 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,255 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,275 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,320 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,365 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,440 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,780 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,955 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,000 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,190 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,580 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

E1B protein, large T-antigen (E1B-55K), Recombinant Protein

 Also Known As   

Recombinant Murine adenovirus A serotype 1 E1B protein, large T-antigen

 Product Gene Name   

E1B-55K recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-433aa, full length protein
 Sequence    MEDRQALEEA GEEMGFPVVN ISGGGRGRRG NYSNDGSGAR ELSLRVNEEV TEPPYNSITY AEVLRLYRQN GFSFFLSNLH FEQIKYFEHR EGEGDLGAII REHGKIVLDP NVVYHLRRPL KIQSLCYIVG RGAVIKVHAS VGQQAVHVYR QLDISPRIMG MLNVTFLECK FHWADDEGVN FERLARHFTL FFLTYESVFF ACDFVGFPGL TLRSTCLLRV EGCTFTSCAV GIHHADVADL KVKACYFNHC SVCIFADGPA DVLRNCATNC DCFVIMEQEG SVVGNSVVYK LPPSRADDLM ICQQGYMYPL SSIHIVRNLS CEYPKLKNNV FSHVDMHVGL RQGLQHFNQC NLSFVYCMLE TESVPKVSFY SSYIQTLTVA QIVQFSREHS RECQCFCGGR HRLLFPSVVH ITPTVVPDRT RFTVDVEELS DDE
 3D Structure    ModBase 3D Structure for P12536
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Murine adenovirus A serotype 1 (MAdV-1) (Murine adenovirus 1)
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of E1B-55K recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for E1B-55K. It may not necessarily be applicable to this product.
 NCBI GI #    119036
 NCBI Accession #    P12536.1 [Other Products]
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 UniProt Primary Accession #    P12536 [Other Products]
 Molecular Weight    49,056 Da [Similar Products]
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 NCBI Official Full Name    E1B 55 kDa protein
 UniProt Protein Name    E1B 55 kDa protein
 UniProt Synonym Protein Names   
E1B protein, large T-antigen; E1B-495R
 UniProt Gene Name    E1B-55K [Similar Products]
 UniProt Synonym Gene Names    E1B-55K [Similar Products]
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 UniProt Comments for E1B-55K    Plays a major role to prevent cellular inhibition of viral genome replication. Assembles an SCF-like E3 ubiquitin ligase complex based on the cellular proteins ELOB, ELOC, CUL5 and RBX1, in cooperation with viral E4orf6. This viral RING-type ligase ubiquitinates cellular substrates and targets them to proteasomal degradation: TP53/p53, LIG4, MRE11-RAD50-NBS1 (MRN) complex, ITGA3, DAXX and BLM. Degradation of host TP53/p53 activity is essential for preventing E1A-induced TP53 accumulation that would otherwise lead to cell apoptosis and growth arrest. E1B-55K also inactivates TP53 transcription-factor activity by binding its transactivation domain. E1B-55K also functions as a SUMO1 E3 ligase for TP53 which causes the latter to be sequestered in promyelocytic leukemia (PML) nuclear bodies thereby contributing to maximal inhibition of TP53 function.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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