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Pias3 recombinant protein :: E3 SUMO-protein ligase PIAS3 (Pias3) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1102721 Pias3 recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $1,425 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,425 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,655 +2 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,655 +2 FREE 8GB USB
1 mg (E-Coli)  /  $2,410 +3 FREE 8GB USB
0.1 mg (Baculovirus)  /  $2,410 +3 FREE 8GB USB
1 mg (Yeast)  /  $2,855 +3 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,855 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

E3 SUMO-protein ligase PIAS3 (Pias3), Recombinant Protein

 Also Known As   

Recombinant Rat E3 SUMO-protein ligase PIAS3 (Pias3)

 Product Synonym Names    E3 SUMO-protein ligase PIAS3; EC=6.3.2.-; KChAP; Potassium channel-associated protein; Protein inhibitor of activated STAT protein 3
 Product Gene Name   

Pias3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-628
 Sequence    MAELGELKHM VMSFRVSELQ VLLGFAGRNK SGRKHELLAK ALHLLKSSCA PSVQMKIKEL YRRRFPRKTL GPSDLSLLSL PPGTSPVGSP SPLASIPPTL LTPGTLLGPK REVDMHPPLP QPVHPDVTMK PLPFYEVYGE LIRPTTLAST SSQRFEEAHF TFALTPQQLQ QILTSREVLP GAKCDYTIQV QLRFCLCETS CPQEDYFPPN LFVKVNGKLC PLPGYLPPTK NGAEPKRPSR PINITPLARL SATVPNTIVV NWSSEFGRNY SLSVYLVRQL TAGTLLQKLR AKGIRNPDHS RALIKEKLTA DPDSEVATTS LRVSLMCPLG KMRLTVPCRA LTCAHLQSFD AALYLQMNEK KPTWTCPVCD KKAPYESLII DGLFMEILNS CSDCDEIQFM EDGSWCPMKP KKEASEVCPP PGYGLDGLQY SPVQEGNQSE NKKRVEVIDL TIESSSDEED LPPTKKHCPV TSAAIPALPG SKGALTSGHQ PSSVLRSPAM GTLGSDFLSS LPLHEYPPAF PLGADIQGLD LFSFLQTESQ HYSPSVITSL DEQDTLGHFF QFRGTPPHFL GPLAPTLGSS HRSATPAPAP GRVSSIVAPG SSLREGHGGP LPSGPSLTGC RSDVISLD
 3D Structure    ModBase 3D Structure for O70260
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information. Additional charge for Tag removal. Tag removal service standardly refers to removal of N-terminal Tag. Any C-terminal Myc-tag may remain intact unless removal of the C-terminal Myc-tag is specifically requested. In most cases tags can be successfully removed. If the lab concludes the protein is no longer stable after tag removal then your protein will be supplied with the tag intact, and you will not be charged for tag removal service.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rattus norvegicus (Rat)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Pias3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Pias3. It may not necessarily be applicable to this product.
 NCBI GI #    17298668
 NCBI GeneID    83614
 NCBI Accession #    NP_113972.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_031784.2 [Other Products]
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 UniProt Primary Accession #    O70260 [Other Products]
 UniProt Related Accession #    O70260 [Other Products]
 Molecular Weight    68,364 Da
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 NCBI Official Full Name    E3 SUMO-protein ligase PIAS3
 NCBI Official Synonym Full Names    protein inhibitor of activated STAT, 3
 NCBI Official Symbol    Pias3 [Similar Products]
 NCBI Protein Information    E3 SUMO-protein ligase PIAS3; KChAP; potassium channel-associated protein; potassium channel regulatory protein KChAP; protein inhibitor of activated STAT protein 3
 UniProt Protein Name    E3 SUMO-protein ligase PIAS3
 UniProt Synonym Protein Names   
KChAP; Potassium channel-associated protein; Protein inhibitor of activated STAT protein 3
 Protein Family    E3 SUMO-protein ligase
 UniProt Gene Name    Pias3 [Similar Products]
 UniProt Entry Name    PIAS3_RAT
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 NCBI Summary for Pias3    voltage-gated K+ channel binding protein; involved in modulating the expression of Kv2 channels [RGD, Feb 2006]
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 UniProt Comments for Pias3    PIAS3: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Monomer. Binds SUMO1 and UBE2I. Interacts with BCL11A, HMGA2, IRF1, MITF and NCOA2. Interacts with STAT5; the interaction occurs on stimulation by PRL. Interacts with GFI1; the interaction relieves the inhibitory effect of PIAS3 on STAT3- mediated transcriptional activity. Interacts with AR, PLAG1 and ZFHX3. Interacts with STAT3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. By dihydrotestosterone (DHT) in prostate cancer cells. Isoform 1 is expressed in most tissues except thymus and small intestine. Isoform 3 is expressed only in brain, heart, thymus, muscle, lung, testis, lactating breast and embryonic stem cells. Belongs to the PIAS family.

Protein type: EC 6.3.2.-; SUMO conjugating system; Nuclear receptor co-regulator

Cellular Component: dendrite; cytoplasm; nuclear speck; synapse; nucleus

Molecular Function: protein C-terminus binding; protein binding; potassium channel regulator activity; enzyme binding; zinc ion binding; protein N-terminus binding; SUMO ligase activity; ligase activity

Biological Process: positive regulation of protein sumoylation; protein sumoylation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; response to hormone stimulus; positive regulation of membrane potential
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 Research Articles on Pias3    1. We have characterized the biological role of a 23-aa domain derived from PIAS3 that induces apoptosis in these cells by inhibiting the transcriptional activity of both MITF and STAT3.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Pias3 recombinant proteinPathways associated with Pias3 recombinant protein
 Reference Product  PubMed Publications
 Stat3 recombinant protein  >88 publications with Pias3 and Stat3
 Stat1 recombinant protein  >8 publications with Pias3 and Stat1
 Max recombinant protein  >3 publications with Pias3 and Max
 Myc recombinant protein  >3 publications with Pias3 and Myc
 Stat5b recombinant protein  >2 publications with Pias3 and Stat5b
 Stat5a recombinant protein  >2 publications with Pias3 and Stat5a
 Gfi1 recombinant protein  >1 publications with Pias3 and Gfi1
 Stat2 recombinant protein  >1 publications with Pias3 and Stat2
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 TNF-alpha NF-kB Signaling Pathway antibodies  TNF-alpha NF-kB Signaling Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
Diseases associated with Pias3 recombinant proteinOrgans/Tissues associated with Pias3 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >7 publications with Pias3 and Inflammation
 Necrosis Antibodies  >7 publications with Pias3 and Necrosis
 Liver Diseases Antibodies  >7 publications with Pias3 and Liver Diseases
 Prostatic Diseases Antibodies  >7 publications with Pias3 and Prostatic Diseases
 Disease Models, Animal Antibodies  >6 publications with Pias3 and Disease Models, Animal
 Adenocarcinoma Antibodies  >5 publications with Pias3 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >4 publications with Pias3 and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >3 publications with Pias3 and Liver Neoplasms
 Hepatitis Antibodies  >3 publications with Pias3 and Hepatitis
 Kidney Diseases Antibodies  >2 publications with Pias3 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with Pias3 and Brain
 Prostate Antibodies  >7 publications with Pias3 and Prostate
 Heart Antibodies  >6 publications with Pias3 and Heart
 Adipose Tissue Antibodies  >3 publications with Pias3 and Adipose Tissue
 Spleen Antibodies  >2 publications with Pias3 and Spleen
 Kidney Antibodies  >2 publications with Pias3 and Kidney
 Embryonic Tissue Antibodies  >1 publications with Pias3 and Embryonic Tissue
 Pituitary Gland Antibodies  >1 publications with Pias3 and Pituitary Gland
 Ovary Antibodies  >1 publications with Pias3 and Ovary
 Connective Tissue Antibodies  >1 publications with Pias3 and Connective Tissue
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