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RANBP2 recombinant protein :: E3 SUMO-protein ligase RanBP2 (RANBP2), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS951299
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $170 +1 FREE 8GB USB
0.01 mg (Yeast)  /  $195 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $220 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $255 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $350 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $415 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $560 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $660 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $900 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $920 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,090 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,135 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,140 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,445 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,640 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,730 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,735 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,190 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

E3 SUMO-protein ligase RanBP2 (RANBP2), partial, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human E3 SUMO-protein ligase RanBP2 (RANBP2), partial

 Product Synonym Names    E3 SUMO-protein ligase RanBP2; EC=6.3.2.-; 358 kDa nucleoporin; Nuclear pore complex protein Nup358; Nucleoporin Nup358; Ran-binding protein 2; RanBP2; p270; Including the following 1 domains:; Putative peptidyl-prolyl cis-trans isomerase; PPIase; EC=5.2.
 Product Gene Name   

RANBP2 recombinant protein

[Similar Products]
 Product Synonym Gene Name    RANBP2; NUP358 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2601-2802. Partial
 Sequence    PTEESSINYT FKTPEKAKEK KKPEDSPSDD DVLIVYELTP TAEQKALATK LKLPPTFFCY KNRPDYVSEE EEDDEDFETA VKKLNGKLYL DGSEKCRPLE ENTADNEKEC IIVWEKKPTV EEKAKADTLK LPPTFFCGVC SDTDEDNGNG EDFQSELQKV QEAQKSQTEE ITSTTDSVYT GGTEVMVPSF CKSEEPDSIT KS
 OMIM    gene 608033
 3D Structure    ModBase 3D Structure for P49792
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of RANBP2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for RANBP2 recombinant protein

   E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB.
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 SDS-PAGE of RANBP2 recombinant protein    RANBP2 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for RANBP2. It may not necessarily be applicable to this product.
 NCBI GI #    150418007
 NCBI GeneID    5903
 NCBI Accession #    NP_006258.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_006267.4 [Other Products]
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 UniProt Primary Accession #    P49792 [Other Products]
 UniProt Secondary Accession #    Q13074; Q15280; Q53TE2; Q59FH7 [Other Products]
 UniProt Related Accession #    P49792 [Other Products]
 Molecular Weight    358,199 Da
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 NCBI Official Full Name    E3 SUMO-protein ligase RanBP2
 NCBI Official Synonym Full Names    RAN binding protein 2
 NCBI Official Symbol    RANBP2 [Similar Products]
 NCBI Official Synonym Symbols   
ANE1; TRP1; TRP2; ADANE; IIAE3; NUP358
[Similar Products]
 NCBI Protein Information    E3 SUMO-protein ligase RanBP2; P270; nucleoporin 358; nucleoporin Nup358; 358 kDa nucleoporin; ran-binding protein 2; transformation-related protein 2; nuclear pore complex protein Nup358; acute necrotizing encephalopathy 1 (autosomal dominant)
 UniProt Protein Name    E3 SUMO-protein ligase RanBP2
 UniProt Synonym Protein Names   
358 kDa nucleoporin; Nuclear pore complex protein Nup358; Nucleoporin Nup358; Ran-binding protein 2; RanBP2; p270
 Protein Family    E3 SUMO-protein ligase
 UniProt Gene Name    RANBP2 [Similar Products]
 UniProt Synonym Gene Names    NUP358; RanBP2 [Similar Products]
 UniProt Entry Name    RBP2_HUMAN
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 NCBI Summary for RANBP2    RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RANBP2    RANBP2: a very large RAN-binding nucleoporin with E3 SUMO-protein ligase activity. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Forms a complex with SUMOylated RanGAP1 (the GTPase activating protein for Ran) that is required for efficient importin alpha/beta dependent nuclear import. May bind RNA or DNA. Component of the nuclear export pathway. Has a specific docking site for the nuclear export factor exportin-1. Contains a cyclophilin type peptidyl-prolyl cis-trans isomerase domain. A giant scaffolding protein that forms filaments extending from the nuclear pore into the cytoplasm. Regulates the localization of mitochondria in photosensory neurons. Deficits of RanBP2 downregulate glucose catabolism and energy homeostasis. Forms a tight complex with RANBP1 and UBE2I. Interacts with SUMO1 and PARK2. For some substrates, sumoylation and nuclear import are linked events. Sumoylates proteins including SP100 and HDAC4 deacetylase.

Protein type: EC 6.3.2.-; Ligase; Adaptor/scaffold; Nuclear export; EC 5.2.1.8; SUMO conjugating system; Nucleoporin

Chromosomal Location of Human Ortholog: 2q12.3

Cellular Component: nuclear membrane; mitochondrion; membrane; nuclear pore; cytosol; nuclear inclusion body

Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; zinc ion binding; RNA binding; Ran GTPase binding; ligase activity

Biological Process: mRNA transport; protein peptidyl-prolyl isomerization; viral reproduction; protein folding; cytokine and chemokine mediated signaling pathway; mitotic nuclear envelope disassembly; pathogenesis; viral infectious cycle; glucose transport; negative regulation of glucokinase activity; protein sumoylation; protein import into nucleus; hexose transport; carbohydrate metabolic process; gene expression; viral transcription; mitotic cell cycle; transmembrane transport

Disease: Encephalopathy, Acute, Infection-induced, Susceptibility To, 3
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 Research Articles on RANBP2    1. Case Report/Review: RANBP2-ALK gene rearrangement in inflammatory myofibroblastic tumors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RANBP2 recombinant proteinPathways associated with RANBP2 recombinant protein
 Reference Product  PubMed Publications
 RAN recombinant protein  >153 publications with RANBP2 and RAN
 RANGAP1 recombinant protein  >39 publications with RANBP2 and RANGAP1
 NUP62 recombinant protein  >2 publications with RANBP2 and NUP62
 HDAC4 recombinant protein  >2 publications with RANBP2 and HDAC4
 XPOT recombinant protein  >1 publications with RANBP2 and XPOT
 TNPO1 recombinant protein  >1 publications with RANBP2 and TNPO1
 MDM2 recombinant protein  >1 publications with RANBP2 and MDM2
 KPNB1 recombinant protein  >1 publications with RANBP2 and KPNB1
 Products by Pathway  Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
 Export Of Viral Ribonucleoproteins From Nucleus Pathway antibodies  Export Of Viral Ribonucleoproteins From Nucleus Pathway Diagram
 Formation And Maturation Of MRNA Transcript Pathway antibodies  Formation And Maturation Of MRNA Transcript Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Glucose Transport Pathway antibodies  Glucose Transport Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 HIV Life Cycle Pathway antibodies  HIV Life Cycle Pathway Diagram
 Hexose Transport Pathway antibodies  Hexose Transport Pathway Diagram
 Host Interactions Of HIV Factors Pathway antibodies  Host Interactions Of HIV Factors Pathway Diagram
Diseases associated with RANBP2 recombinant proteinOrgans/Tissues associated with RANBP2 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >17 publications with RANBP2 and Neoplasms
 Nervous System Diseases Antibodies  >12 publications with RANBP2 and Nervous System Diseases
 Carcinoma Antibodies  >5 publications with RANBP2 and Carcinoma
 Adenocarcinoma Antibodies  >4 publications with RANBP2 and Adenocarcinoma
 Influenza, Human Antibodies  >4 publications with RANBP2 and Influenza, Human
 Liver Neoplasms Antibodies  >3 publications with RANBP2 and Liver Neoplasms
 Inflammation Antibodies  >3 publications with RANBP2 and Inflammation
 Lung Diseases Antibodies  >3 publications with RANBP2 and Lung Diseases
 Drug Toxicity Antibodies  >2 publications with RANBP2 and Drug Toxicity
 Necrosis Antibodies  >2 publications with RANBP2 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with RANBP2 and Brain
 Muscle Antibodies  >6 publications with RANBP2 and Muscle
 Placenta Antibodies  >1 publications with RANBP2 and Placenta
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