NP_001271220.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,390 Da
NCBI Official Full Name
E3 ubiquitin-protein ligase Hakai isoform 2
NCBI Official Synonym Full Names
Cbl proto-oncogene like 1
NCBI Protein Information
E3 ubiquitin-protein ligase Hakai
UniProt Protein Name
E3 ubiquitin-protein ligase Hakai
UniProt Synonym Protein Names
Casitas B-lineage lymphoma-transforming sequence-like protein 1; RING finger protein 188; RING-type E3 ubiquitin transferase HakaiCurated; c-Cbl-like protein 1
UniProt Synonym Gene Names
NCBI Summary for CBLL1
This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. [provided by RefSeq, Aug 2011]
UniProt Comments for CBLL1
Promotes ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation.
Research Articles on CBLL1
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Products associated with CBLL1 recombinant protein
Diseases associated with CBLL1 recombinant protein
Organs/Tissues associated with CBLL1 recombinant protein
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