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RFWD2 recombinant protein :: E3 ubiquitin-protein ligase RFWD2 (RFWD2) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1476060 RFWD2 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $1,165 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,305 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,560 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,570 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,615 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,660 +2 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,735 +2 FREE 8GB USB
0.5 mg (Yeast)  /  $1,830 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,340 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,370 +2 FREE 8GB USB
1 mg (E-Coli)  /  $2,465 +3 FREE 8GB USB
1 mg (Yeast)  /  $2,765 +3 FREE 8GB USB
1 mg (Baculovirus)  /  $3,100 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

E3 ubiquitin-protein ligase RFWD2 (RFWD2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human E3 ubiquitin-protein ligase RFWD2 (RFWD2)

 Product Gene Name   

RFWD2 recombinant protein

[Similar Products]
 Product Synonym Gene Name    RFWD2 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS1476060 COA    COA PDF
 Sequence Positions    1-731aa, full length protein
 Sequence    MSGSRQAGSG SAGTSPGSSA ASSVTSASSS LSSSPSPPSV AVSAAALVSG GVAQAAGSGG LGGPVRPVLV APAVSGSGGG AVSTGLSRHS CAARPSAGVG GSSSSLGSGS RKRPLLAPLC NGLINSYEDK SNDFVCPICF DMIEEAYMTK CGHSFCYKCI HQSLEDNNRC PKCNYVVDNI DHLYPNFLVN ELILKQKQRF EEKRFKLDHS VSSTNGHRWQ IFQDWLGTDQ DNLDLANVNL MLELLVQKKK QLEAESHAAQ LQILMEFLKV ARRNKREQLE QIQKELSVLE EDIKRVEEMS GLYSPVSEDS TVPQFEAPSP SHSSIIDSTE YSQPPGFSGS SQTKKQPWYN STLASRRKRL TAHFEDLEQC YFSTRMSRIS DDSRTASQLD EFQECLSKFT RYNSVRPLAT LSYASDLYNG SSIVSSIEFD RDCDYFAIAG VTKKIKVYEY DTVIQDAVDI HYPENEMTCN SKISCISWSS YHKNLLASSD YEGTVILWDG FTGQRSKVYQ EHEKRCWSVD FNLMDPKLLA SGSDDAKVKL WSTNLDNSVA SIEAKANVCC VKFSPSSRYH LAFGCADHCV HYYDLRNTKQ PIMVFKGHRK AVSYAKFVSG EEIVSASTDS QLKLWNVGKP YCLRSFKGHI NEKNFVGLAS NGDYIACGSE NNSLYLYYKG LSKTLLTFKF DTVKSVLDKD RKEDDTNEFV SAVCWRALPD GESNVLIAAN SQGTIKVLEL V
 OMIM    608067
 3D Structure    ModBase 3D Structure for Q8NHY2
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of RFWD2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for RFWD2. It may not necessarily be applicable to this product.
 NCBI GI #    50233824
 NCBI GeneID    64326
 NCBI Accession #    NP_001001740.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001001740.3 [Other Products]
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 UniProt Primary Accession #    Q8NHY2 [Other Products]
 UniProt Secondary Accession #    Q504W6; Q6H103; Q9H6L7; E9PKI0; X5D9B4 [Other Products]
 UniProt Related Accession #    Q8NHY2 [Other Products]
 Molecular Weight    14,914 Da
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 NCBI Official Full Name    E3 ubiquitin-protein ligase RFWD2 isoform b
 NCBI Official Synonym Full Names    COP1, E3 ubiquitin ligase
 NCBI Official Symbol    COP1 [Similar Products]
 NCBI Official Synonym Symbols   
RFWD2; RNF200
[Similar Products]
 NCBI Protein Information    E3 ubiquitin-protein ligase RFWD2
 UniProt Protein Name    E3 ubiquitin-protein ligase RFWD2
 UniProt Synonym Protein Names   
Constitutive photomorphogenesis protein 1 homolog; hCOP1; RING finger and WD repeat domain protein 2; RING finger protein 200; RING-type E3 ubiquitin transferase RFWD2Curated
 Protein Family    E3 ubiquitin-protein ligase
 UniProt Gene Name    RFWD2 [Similar Products]
 UniProt Synonym Gene Names    COP1; RNF200; hCOP1 [Similar Products]
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 UniProt Comments for RFWD2    E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif (Probable).
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 Research Articles on RFWD2    1. Authors demonstrate that mtp53 prevents the COP1/DET1 complex from ubiquitinating ETS2 and thereby marking it for destruction. Authors show that mtp53 destabilizes DET1 and also disrupts the DET1/ETS2 complex thereby preventing ETS2 degradation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RFWD2 recombinant proteinPathways associated with RFWD2 recombinant protein
 Reference Product  PubMed Publications
 JUN recombinant protein  >14 publications with RFWD2 and JUN
 TP53 recombinant protein  >4 publications with RFWD2 and TP53
 DET1 recombinant protein  >4 publications with RFWD2 and DET1
 Products by Pathway  Pathway Diagram
 Autodegradation Of The E3 Ubiquitin Ligase COP1 Pathway antibodies  Autodegradation Of The E3 Ubiquitin Ligase COP1 Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 G1/S DNA Damage Checkpoints Pathway antibodies  G1/S DNA Damage Checkpoints Pathway Diagram
 Stabilization Of P53 Pathway antibodies  Stabilization Of P53 Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 P53 Pathway antibodies  P53 Pathway Diagram
 P53 Signaling Pathway antibodies  P53 Signaling Pathway Diagram
Diseases associated with RFWD2 recombinant proteinOrgans/Tissues associated with RFWD2 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >17 publications with RFWD2 and Neoplasms
 Breast Neoplasms Antibodies  >3 publications with RFWD2 and Breast Neoplasms
 Carcinoma Antibodies  >2 publications with RFWD2 and Carcinoma
 Neoplasms, Experimental Antibodies  >2 publications with RFWD2 and Neoplasms, Experimental
 Fatty Liver Antibodies  >2 publications with RFWD2 and Fatty Liver
 Gonadal Disorders Antibodies  >1 publications with RFWD2 and Gonadal Disorders
 Liver Neoplasms, Experimental Antibodies  >1 publications with RFWD2 and Liver Neoplasms, Experimental
 Liver Diseases Antibodies  >1 publications with RFWD2 and Liver Diseases
 Hyperplasia Antibodies  >1 publications with RFWD2 and Hyperplasia
 Liver Neoplasms Antibodies  >1 publications with RFWD2 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >7 publications with RFWD2 and Liver
 Lung Antibodies  >2 publications with RFWD2 and Lung
 Skin Antibodies  >2 publications with RFWD2 and Skin
 Connective Tissue Antibodies  >2 publications with RFWD2 and Connective Tissue
 Heart Antibodies  >1 publications with RFWD2 and Heart
 Embryonic Tissue Antibodies  >1 publications with RFWD2 and Embryonic Tissue
 Pancreas Antibodies  >1 publications with RFWD2 and Pancreas
 Prostate Antibodies  >1 publications with RFWD2 and Prostate
 Blood Antibodies  >1 publications with RFWD2 and Blood
 Stomach Antibodies  >1 publications with RFWD2 and Stomach
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