NP_001093149.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
71,989 Da
NCBI Official Full Name
E3 ubiquitin-protein ligase TRIM32
NCBI Official Synonym Full Names
tripartite motif containing 32
NCBI Protein Information
E3 ubiquitin-protein ligase TRIM32
UniProt Protein Name
E3 ubiquitin-protein ligase TRIM32
UniProt Synonym Protein Names
72 kDa Tat-interacting protein; RING-type E3 ubiquitin transferase TRIM32Curated; Tripartite motif-containing protein 32; Zinc finger protein HT2A
UniProt Synonym Gene Names
NCBI Summary for TRIM32
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008]
UniProt Comments for TRIM32
Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.
Research Articles on TRIM32
Precautions
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Products associated with TRIM32 recombinant protein
Pathways associated with TRIM32 recombinant protein
Diseases associated with TRIM32 recombinant protein
Organs/Tissues associated with TRIM32 recombinant protein
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