NP_001001894.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
194,059 Da
NCBI Official Full Name
E3 ubiquitin-protein ligase TTC3 isoform 1
NCBI Official Synonym Full Names
tetratricopeptide repeat domain 3
NCBI Protein Information
E3 ubiquitin-protein ligase TTC3
UniProt Protein Name
E3 ubiquitin-protein ligase TTC3
UniProt Synonym Protein Names
Protein DCRR1; RING finger protein 105; RING-type E3 ubiquitin transferase TTC3Curated; TPR repeat protein D; Tetratricopeptide repeat protein 3; TPR repeat protein 3
UniProt Synonym Gene Names
UniProt Comments for TTC3
E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.
Research Articles on TTC3
Precautions
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Disclaimer
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Diseases associated with TTC3 recombinant protein
Organs/Tissues associated with TTC3 recombinant protein
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