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Park2 recombinant protein :: E3 ubiquitin-protein ligase parkin (Park2) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1337857 Park2 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $885 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $975 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,100 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,185 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,305 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,310 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,350 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,395 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,485 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,855 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,000 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,035 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,255 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,635 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

E3 ubiquitin-protein ligase parkin (Park2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Rat E3 ubiquitin-protein ligase parkin (Park2)

 Product Gene Name   

Park2 recombinant protein

[Similar Products]
 Product Synonym Gene Name    Park2 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS1337857 COA    COA PDF
 Sequence Positions    1-465. Full-length.
 Sequence    MIVFVRFNSS YGFPVEVDSD TSIFQLKEVV AKRQGVPADQ LRVIFAGKEL QNHLTVQNCD LEQQSIVHIV QRPQRKSHET NASGGDKPQS TPEGSIWEPR SLTRVDLSSH ILPADSVGLA VILDTDSKSD SEAARGPEAK PTYHSFFVYC KGPCHKVQPG KLRVQCGTCR QATLTLAQGP SCWDDVLIPN RMSGECQSPD CPGTRAEFFF KCGAHPTSDK DTSVALNLIT NNSRSIPCIA CTDVRNPVLV FQCNHRHVIC LDCFHLYCVT RLNDRQFVHD AQLGYSLPCV AGCPNSLIKE LHHFRILGEE QYNRYQQYGA EECVLQMGGV LCPRPGCGAG LLPEQGQKKV TCEGGNGLGC GFVFCRDCKE AYHEGECDSM FEASGATSQA YRVDQRAAEQ ARWEEASKET IKKTTKPCPR CNVPIEKNGG CMHMKCPQPQ CKLEWCWNCG CEWNRACMGD HWFDV
 3D Structure    ModBase 3D Structure for Q9JK66
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rat
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Park2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Park2 recombinant protein

   The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.
NCBI/Uniprot data below describe general gene information for Park2. It may not necessarily be applicable to this product.
 NCBI GI #    11464987
 NCBI GeneID    56816
 NCBI Accession #    NP_064478.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_020093.1 [Other Products]
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 UniProt Primary Accession #    Q9JK66 [Other Products]
 UniProt Secondary Accession #    Q8K5C3; Q8K5C4; Q8K5C5; Q8K5C6; Q8VHY6; Q9JLL1; Q9JM64 [Other Products]
 UniProt Related Accession #    Q9JK66 [Other Products]
 Molecular Weight    22,288 Da
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 NCBI Official Full Name    E3 ubiquitin-protein ligase parkin
 NCBI Official Synonym Full Names    parkin RBR E3 ubiquitin protein ligase
 NCBI Official Symbol    Prkn [Similar Products]
 NCBI Official Synonym Symbols   
Park; Park2
[Similar Products]
 NCBI Protein Information    E3 ubiquitin-protein ligase parkin
 UniProt Protein Name    E3 ubiquitin-protein ligase parkin
 UniProt Synonym Protein Names   
Parkin RBR E3 ubiquitin-protein ligase
 Protein Family    E3 ubiquitin-protein ligase
 UniProt Gene Name    Prkn [Similar Products]
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 NCBI Summary for Park2    localized to the cytoplasm in neurons of many regions of the brain; has N-terminal ubiquitin and ring-IBR-ring finger domains [RGD, Feb 2006]
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 UniProt Comments for Park2    Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation. Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation. Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy. Promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1 and USP30. Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains following mitochondrial damage, leading to mitophagy. Mediates 'Lys-48'-linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome; possibly playing a role in the regulation of neuron death. Limits the production of reactive oxygen species (ROS). Regulates cyclin-E during neuronal apoptosis. In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress. Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene.
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 Research Articles on Park2    1. These findings demonstrate a novel role for Parkin in synaptic AMPA receptor internalization and suggest a Parkin-dependent mechanism for hippocampal dysfunction that may explain cognitive deficits associated with some forms of PD.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Park2 recombinant proteinDiseases associated with Park2 recombinant protein
 Products by Pathway  Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Disease Name  Pubmed Publications
 Parkinsonian Disorders Antibodies  >58236 publications with Park2 and Parkinsonian Disorders
 Nervous System Diseases Antibodies  >57970 publications with Park2 and Nervous System Diseases
 Movement Disorders Antibodies  >57924 publications with Park2 and Movement Disorders
 Brain Diseases Antibodies  >57822 publications with Park2 and Brain Diseases
 Parkinson Disease Antibodies  >51406 publications with Park2 and Parkinson Disease
 Neurodegenerative Diseases Antibodies  >49773 publications with Park2 and Neurodegenerative Diseases
 Parkinson Disease, Secondary Antibodies  >6444 publications with Park2 and Parkinson Disease, Secondary
 Disease Models, Animal Antibodies  >4776 publications with Park2 and Disease Models, Animal
 Tremor Antibodies  >4598 publications with Park2 and Tremor
 Cognition Disorders Antibodies  >3378 publications with Park2 and Cognition Disorders
Organs/Tissues associated with Park2 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >4 publications with Park2 and Heart
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