NP_067078.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,435 Da
NCBI Official Full Name
E3 ubiquitin-protein ligase pellino homolog 2
NCBI Official Synonym Full Names
pellino E3 ubiquitin protein ligase family member 2
NCBI Protein Information
E3 ubiquitin-protein ligase pellino homolog 2
UniProt Protein Name
E3 ubiquitin-protein ligase pellino homolog 2
UniProt Synonym Protein Names
RING-type E3 ubiquitin transferase pellino homolog 2Curated
UniProt Synonym Gene Names
UniProt Comments for PELI2
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
Research Articles on PELI2
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Products associated with PELI2 recombinant protein
Pathways associated with PELI2 recombinant protein
Diseases associated with PELI2 recombinant protein
Organs/Tissues associated with PELI2 recombinant protein
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