Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow EGF  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • nitric oxide synthase 1 (neuronal) (NOS1) ELISA Kit
 • Enteropeptidase (TMPRSS15), partial Recombinant Protein
 • Urea Transporter A1 (SLC14A2) Antibody
 • Human Chorionic Gonadotropin (hCG) >98% Pure Native Protein
 • c-erbB2, p185 Antibody
 • Cholecystokinin octapeptide (CCK-8) ELISA Kit
 • Ubiquitin Conjugating Enzyme E2A (UBE2A) Recombinant Protein
 • 3-isopropylmalate dehydratase large subunit (leuC) Recombinant Protein
 • Monocyte Chemotatic Protein 1 (MCP-1) Antibody
 • Fibroblast Growth Factor 7 (FGF7) ELISA Kit
 • CD74 Antibody
 • FABP7 Antibody
 • ACVR1 Antibody
 • anti-cardiolipin antibody IgG, ACA-IgG ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

EGF recombinant protein

Scan QR to view Datasheet Catalog #    MBS538184 EGF recombinant protein
Unit / Price
0.1 mg  /  $170 +1 FREE 8GB USB
0.5 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EGF, Recombinant Protein

 Also Known As   

EGF protein (Mouse)

 Product Synonym Names    Epidermal Growth Factor protein; URG protein; Urogastrone protein
 Product Gene Name   

EGF recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence    Region of murine EGF protein correspond ing to amino acids NSYPGCPSSY DGYCLNGGVC MHIESLDSYT CNCVIGYSGD RCQTRDLRWW ELR
 OMIM    131550
 3D Structure    ModBase 3D Structure for P00533
Section Bar
 Host    Mouse
Section Bar
 Purity/Purification    > 98% pure
 Form/Format    Lyophilized from 10mM Na3PO4, pH 7.5. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
Section Bar
 Protein Type    Recombinant
 Biological Significance    Epidermal Growth Factor (EGF) is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells. Additionally, EGF has been shown to inhibit gastric secretion, and to be involved in wound healing. EGF signals through a receptor known as c-erbB, which is a class I tyrosine kinase receptor. This receptor also binds with TGF alpha and VGF (vaccinia virus growth factor).
 Bioactivity    The ED50 was determined by a cell proliferation assay using BALB/c 3T3 cells is 1 x 10^7 units/mg.
 Endotoxin Levels    Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
 Expression System    E Coli
Section Bar
 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of EGF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for EGF recombinant protein

   Purified recombinant Mouse EGF protein
 Product Categories/Family for EGF recombinant protein    Cytokines & Growth Factors
 Applications Tested/Suitable for EGF recombinant protein   

User optimized

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for EGF. It may not necessarily be applicable to this product.
 NCBI GI #    326467049
 NCBI GeneID    1956
 NCBI Accession #    ADZ75461.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P00533 [Other Products]
 UniProt Secondary Accession #    O00688; O00732; P06268; Q14225; Q68GS5; Q92795; Q9BZS2; Q9GZX1; Q9H2C9; Q9H3C9; Q9UMD7 [Other Products]
 UniProt Related Accession #    P00533 [Other Products]
 Molecular Weight    6.0 kDa
Table BarTOPTable Bar
 NCBI Official Full Name    epidermal growth factor receptor
 NCBI Official Synonym Full Names    epidermal growth factor receptor
 NCBI Official Symbol    EGFR [Similar Products]
 NCBI Official Synonym Symbols   
ERBB; HER1; mENA; ERBB1; PIG61; NISBD2
[Similar Products]
 NCBI Protein Information    epidermal growth factor receptor
 UniProt Protein Name    Epidermal growth factor receptor
 UniProt Synonym Protein Names   
Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
 Protein Family    EGF-like domain containing protein
 UniProt Gene Name    EGFR [Similar Products]
 UniProt Synonym Gene Names    ERBB; ERBB1; HER1 [Similar Products]
 UniProt Entry Name    EGFR_HUMAN
Section Bar
 NCBI Summary for EGF    The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Section Bar
 UniProt Comments for EGF    EGFR: a receptor tyrosine kinase. This is a receptor for epidermal growth factor (EGF) and related growth factors including TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30, and vaccinia virus growth factor. EGFR is involved in the control of cell growth and differentiation. It is a single-pass transmembrane tyrosine kinase. Ligand binding to this receptor results in receptor dimerization, autophosphorylation (in trans), activation of various downstream signaling molecules and lysosomal degradation. It can be phosphorylated and activated by Src. Activated EGFR binds the SH2 domain of phospholipase C-gamma (PLC-gamma), activating PLC-gamma-mediated downstream signaling. Phosphorylated EGFR binds Cbl, leading to its ubiquitination and degradation. Grb2 and SHC bind to phospho-EGFR and are involved in the activation of MAP kinase signaling pathways. Phosphorylation on Ser and Thr residues is thought to represent a mechanism for attenuation of EGFR kinase activity. EGFR is overexpressed in breast, head and neck cancers, correlating with poor survival. Activating somatic mutations are seen in lung cancer, corresponding to the minority of patients with strong responses to the EGFR inhibitor Iressa (gefitinib). Mutations and amplifications are also seen in glioblastoma, and upregulation is seen in colon cancer and neoplasms. In xenografts, inhibitors synergize with cytotoxic drugs in the inhibition of many tumor types. Inhibitors include: Iressa/ZD1839, Erbitux, Tarceva, and lapatinib. Four alternatively spliced isoforms have been described.

Protein type: Kinase, protein; Tumor suppressor; Protein kinase, TK; EC 2.7.10.1; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; EGFR family

Chromosomal Location of Human Ortholog: 7p12

Cellular Component: extracellular space; endoplasmic reticulum membrane; nuclear membrane; focal adhesion; cell surface; basolateral plasma membrane; integral to membrane; lipid raft; Golgi membrane; membrane; perinuclear region of cytoplasm; apical plasma membrane; cytoplasm; plasma membrane; AP-2 adaptor complex; endosome membrane; nucleus; receptor complex; endosome

Molecular Function: identical protein binding; epidermal growth factor receptor activity; epidermal growth factor binding; nitric-oxide synthase regulator activity; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; protein phosphatase binding; protein kinase binding; integrin binding; actin filament binding; protein binding; enzyme binding; transmembrane receptor activity; MAP kinase kinase kinase activity; protein heterodimerization activity; ubiquitin protein ligase binding; protein-tyrosine kinase activity; double-stranded DNA binding; chromatin binding; glycoprotein binding; ATP binding

Biological Process: circadian rhythm; diterpenoid metabolic process; positive regulation of nitric oxide biosynthetic process; activation of MAPKK activity; nerve growth factor receptor signaling pathway; alkanesulfonate metabolic process; protein insertion into membrane; positive regulation of vasodilation; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; positive regulation of MAP kinase activity; cell-cell adhesion; positive regulation of fibroblast proliferation; ovulation cycle; cell surface receptor linked signal transduction; hair follicle development; positive regulation of superoxide release; negative regulation of mitotic cell cycle; positive regulation of DNA repair; fibroblast growth factor receptor signaling pathway; digestive tract morphogenesis; response to osmotic stress; phospholipase C activation; hydrogen peroxide metabolic process; response to hydroxyisoflavone; positive regulation of transcription from RNA polymerase II promoter; response to oxidative stress; regulation of nitric-oxide synthase activity; response to calcium ion; negative regulation of protein catabolic process; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; negative regulation of epidermal growth factor receptor signaling pathway; axon guidance; tongue development; embryonic placenta development; peptidyl-tyrosine phosphorylation; translation; positive regulation of smooth muscle cell proliferation; protein amino acid autophosphorylation; signal transduction; positive regulation of synaptic transmission, glutamatergic; learning and/or memory; positive regulation of cell proliferation; salivary gland morphogenesis; response to stress; regulation of peptidyl-tyrosine phosphorylation; epidermal growth factor receptor signaling pathway; ossification; phosphoinositide-mediated signaling; MAPKKK cascade; liver development; cell proliferation; positive regulation of protein kinase B signaling cascade; cerebral cortex cell migration; calcium-dependent phospholipase A2 activation; positive regulation of vasoconstriction; innate immune response; positive regulation of protein amino acid phosphorylation; astrocyte activation; response to cobalamin; positive regulation of DNA replication; positive regulation of phosphorylation; lung development; positive regulation of cell migration; positive regulation of inflammatory response

Disease: Lung Cancer
Table BarTOPTable Bar
 Research Articles on EGF    1. expression of EGFR, CDKN2A and TP53 may be associated with tumour pathology but is not induced by HPV
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products related to EGF protein (Mouse)
 Catalog #  Product Name  Catalog #  Product Name
 MBS004190  Rabbit MEGF9 Antibody  MBS1274969  EGFL6 cDNA Clone
 MBS9381420  Plant Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) ELISA Kit  MBS9227078  EGFR Antibody (Y978) Blocking Peptide
 MBS2501726  Human EGFR2 (Epidermal Growth Factor Receptor 2) ELISA Kit  MBS568239  VEGF(GV39M) Antibody
 MBS088481  Porcine VEGF Co Regulated Chemokine 1 ELISA Kit  MBS2535994  EGFR (Phospho-Y869)
 MBS692274  Human VEGF165-Biotin  MBS099327  Pigeon VEGF Co Regulated Chemokine 1 ELISA Kit
Pathways associated with EGF recombinant proteinDiseases associated with EGF recombinant protein
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >10017 publications with EGF and Carcinoma
 Lung Neoplasms Antibodies  >5623 publications with EGF and Lung Neoplasms
 Kidney Diseases Antibodies  >4244 publications with EGF and Kidney Diseases
 Adenocarcinoma Antibodies  >4208 publications with EGF and Adenocarcinoma
 Small Cell Lung Carcinoma Antibodies  >3806 publications with EGF and Small Cell Lung Carcinoma
 Carcinoma, Non-Small-Cell Lung Antibodies  >3760 publications with EGF and Carcinoma, Non-Small-Cell Lung
 Disease Progression Antibodies  >3273 publications with EGF and Disease Progression
 Breast Neoplasms Antibodies  >2742 publications with EGF and Breast Neoplasms
 Carcinoma, Squamous Cell Antibodies  >2672 publications with EGF and Carcinoma, Squamous Cell
 Head and Neck Neoplasms Antibodies  >2103 publications with EGF and Head and Neck Neoplasms
Organs/Tissues associated with EGF recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >7767 publications with EGF and Lung
 Kidney Antibodies  >5862 publications with EGF and Kidney
 Vascular Antibodies  >2612 publications with EGF and Vascular
 Brain Antibodies  >2199 publications with EGF and Brain
 Liver Antibodies  >1371 publications with EGF and Liver
 Heart Antibodies  >1294 publications with EGF and Heart
 Skin Antibodies  >1255 publications with EGF and Skin
 Muscle Antibodies  >707 publications with EGF and Muscle
 Prostate Antibodies  >683 publications with EGF and Prostate
 Bone Antibodies  >554 publications with EGF and Bone
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions