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ENA-78 recombinant protein :: ENA-78 / CXCL5 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS695999 ENA-78 recombinant protein
Unit / Price
0.005 mg  /  $125 +1 FREE 8GB USB
0.02 mg  /  $195 +1 FREE 8GB USB
0.1 mg  /  $505 +1 FREE 8GB USB
0.5 mg  /  $1,410 +1 FREE 8GB USB
1 mg  /  $2,320 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ENA-78 / CXCL5, Recombinant Protein

★Popular Item★
 Also Known As   

Human ENA-78 / CXCL5 (8-78 a.a.)

 Product Synonym Names    Recombinant Human ENA-78 (CXCL5) (8-78 a.a.)
 Product Gene Name   

ENA-78 recombinant protein

[Similar Products]
 Product Synonym Gene Name    CXCL5 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    LRELRCVCL QTTQGVHPK MISNLQVFA IGPQCSKVE VVASLKNGK EICLDPEAP FLKKVIQKI LDGGNKEN
 OMIM    600324
 3D Structure    ModBase 3D Structure for P42830
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 Host    E Coli
 Species Reactivity    Species Reactivity: Human
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 Purity/Purification    Above 98% as determined by SDS-PAGE Analysis.
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 Biological Activity    Determined by its ability to chemoattract human neutrophils using a concentration range of 10.0-100.0 ng/ml.
 Cell Type    Monocytes and Macrophages, Endothelial Cells
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 Preparation and Storage    At -20 degree C
 Other Notes    Small volumes of ENA-78 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ENA-78 recombinant protein

   ENA-78 is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. ENA-78 is a chemoattractant for neutrophils. Three N-terminal truncated variants of human ENA-78; ENA 5-78, ENA 8-78, ENA 9-78, contain 74, 71, and 70 amino acid residues, respectively, possess increased biological activity. ENA-78 contains the four conserved cysteine residues present in CXC chemokines, and also contains the ‘ELR' motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors. Recombinant human ENA-78 is a 7.8 kDa protein consisting of 71 amino acid residues.
 Product Categories/Family for ENA-78 recombinant protein    Angiogenesis; Inflammation; Chemotaxis
NCBI/Uniprot data below describe general gene information for ENA-78. It may not necessarily be applicable to this product.
 NCBI GI #    1169525
 NCBI GeneID    6374
 NCBI Accession #    P42830.1 [Other Products]
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 UniProt Primary Accession #    P42830 [Other Products]
 UniProt Secondary Accession #    Q96QE1 [Other Products]
 UniProt Related Accession #    P42830 [Other Products]
 Molecular Weight    11,972 Da
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 NCBI Official Full Name    C-X-C motif chemokine 5
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) ligand 5
 NCBI Official Symbol    CXCL5 [Similar Products]
 NCBI Official Synonym Symbols   
SCYB5; ENA-78
[Similar Products]
 NCBI Protein Information    C-X-C motif chemokine 5; neutrophil-activating protein 78; neutrophil-activating peptide ENA-78; epithelial-derived neutrophil-activating protein 78; small inducible cytokine subfamily B (Cys-X-Cys), member 5 (epithelial-derived neutrophil-activating peptide 78)
 UniProt Protein Name    C-X-C motif chemokine 5
 UniProt Synonym Protein Names   
ENA-78(1-78); Epithelial-derived neutrophil-activating protein 78; Neutrophil-activating peptide ENA-78; Small-inducible cytokine B5Cleaved into the following 2 chains:ENA-78(8-78); ENA-78(9-78)
 UniProt Gene Name    CXCL5 [Similar Products]
 UniProt Synonym Gene Names    ENA78; SCYB5 [Similar Products]
 UniProt Entry Name    CXCL5_HUMAN
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 NCBI Summary for ENA-78    This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]
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 UniProt Comments for ENA-78    CXCL5: Involved in neutrophil activation. In vitro, ENA-78(8- 78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity; CXCR chemokine receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; cell-cell signaling; positive regulation of cell proliferation; neutrophil mediated immunity; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; immune response; signal transduction; chemotaxis; inflammatory response
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 Research Articles on ENA-78    1. Citrullinated ENA-78/CXCL5 is highly correlated with rheumatoid arthritis disease activity and, unlike noncitrullinated ENA-78/CXCL5, recruits monocytes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ENA-78 recombinant proteinPathways associated with ENA-78 recombinant protein
 Reference Product  PubMed Publications
 CXCR2 recombinant protein  >85 publications with ENA-78 and CXCR2
 CCL5 recombinant protein  >73 publications with ENA-78 and CCL5
 CCL20 recombinant protein  >39 publications with ENA-78 and CCL20
 CXCR1 recombinant protein  >26 publications with ENA-78 and CXCR1
 CXCL11 recombinant protein  >21 publications with ENA-78 and CXCL11
 CXCL16 recombinant protein  >11 publications with ENA-78 and CXCL16
 CCR3 recombinant protein  >8 publications with ENA-78 and CCR3
 CCR1 recombinant protein  >8 publications with ENA-78 and CCR1
 CCL19 recombinant protein  >8 publications with ENA-78 and CCL19
 CCR5 recombinant protein  >8 publications with ENA-78 and CCR5
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
Diseases associated with ENA-78 recombinant proteinOrgans/Tissues associated with ENA-78 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >234 publications with ENA-78 and Inflammation
 Necrosis Antibodies  >100 publications with ENA-78 and Necrosis
 Respiratory Tract Diseases Antibodies  >97 publications with ENA-78 and Respiratory Tract Diseases
 Lung Diseases Antibodies  >86 publications with ENA-78 and Lung Diseases
 Disease Models, Animal Antibodies  >63 publications with ENA-78 and Disease Models, Animal
 Carcinoma Antibodies  >60 publications with ENA-78 and Carcinoma
 Cardiovascular Diseases Antibodies  >43 publications with ENA-78 and Cardiovascular Diseases
 Fibrosis Antibodies  >28 publications with ENA-78 and Fibrosis
 Lung Neoplasms Antibodies  >27 publications with ENA-78 and Lung Neoplasms
 Pneumonia Antibodies  >24 publications with ENA-78 and Pneumonia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >296 publications with ENA-78 and Blood
 Lung Antibodies  >127 publications with ENA-78 and Lung
 Vascular Antibodies  >97 publications with ENA-78 and Vascular
 Intestine Antibodies  >34 publications with ENA-78 and Intestine
 Skin Antibodies  >29 publications with ENA-78 and Skin
 Kidney Antibodies  >17 publications with ENA-78 and Kidney
 Brain Antibodies  >17 publications with ENA-78 and Brain
 Connective Tissue Antibodies  >16 publications with ENA-78 and Connective Tissue
 Embryonic Tissue Antibodies  >14 publications with ENA-78 and Embryonic Tissue
 Uterus Antibodies  >13 publications with ENA-78 and Uterus
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