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ENA78 recombinant protein

Scan QR to view Datasheet Catalog #    MBS539547 ENA78 recombinant protein
Unit / Price
0.02 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ENA78, Recombinant Protein

 Also Known As   

ENA78 protein

 Product Synonym Names    ENA-78; ENA-78 protein; ENA 78; ENA 78 protein; Mouse protein; CXCL5 protein; LIX protein; ENA78; Epithelial Neutrophil Activating Peptide-78 protein
 Product Gene Name   

ENA78 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Region of ENA78 protein correspond ing to amino acids AAVLRELRCV CLQTTQGVHP KMISNLQVFA IGPQCSKVEV VASLKNGKEI CLDPEAPFLK KVIQKILDGG NKEN.
 OMIM    600324
 3D Structure    ModBase 3D Structure for P42830
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 Host    Human
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 Purity/Purification    > 98% pure
 Form/Format    Supplied as a lyophilized powder.
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 Protein Type    Recombinant
 Biological Significance    ENA-78 is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. ENA-78 is a chemoattractant for neutrophils. The Mouse homolog of ENA-78 is called LIX. The three naturally occurring variants of human ENA-78; ENA 5-78, ENA 9-78 and ENA 10-78, contain 74, 70, and 69 amino acid residues, respectively, and possess the same biological activity. ENA-78 contains the four conserved cysteine residues present in CXC chemokines, and also contains the 'ELR' motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors.
 Bioactivity    Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration of 5.0-10.0 ng/ml.
 Endotoxin Levels    Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
 Expression System    E Coli
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 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of ENA78 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for ENA78 recombinant protein

   Purified recombinant Human ENA78 protein
 Product Categories/Family for ENA78 recombinant protein    Cytokines & Growth Factors
 Applications Tested/Suitable for ENA78 recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for ENA78. It may not necessarily be applicable to this product.
 NCBI GI #    471243
 NCBI GeneID    6374
 NCBI Accession #    CAA55355.1 [Other Products]
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 UniProt Primary Accession #    P42830 [Other Products]
 UniProt Secondary Accession #    Q96QE1 [Other Products]
 UniProt Related Accession #    P42830 [Other Products]
 Molecular Weight    8 kDa
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 NCBI Official Full Name    ENA-78
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) ligand 5
 NCBI Official Symbol    CXCL5 [Similar Products]
 NCBI Official Synonym Symbols   
SCYB5; ENA-78
[Similar Products]
 NCBI Protein Information    C-X-C motif chemokine 5
 UniProt Protein Name    C-X-C motif chemokine 5
 UniProt Synonym Protein Names   
ENA-78(1-78); Epithelial-derived neutrophil-activating protein 78; Neutrophil-activating peptide ENA-78; Small-inducible cytokine B5
 UniProt Gene Name    CXCL5 [Similar Products]
 UniProt Synonym Gene Names    ENA78; SCYB5 [Similar Products]
 UniProt Entry Name    CXCL5_HUMAN
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 NCBI Summary for ENA78    This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]
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 UniProt Comments for ENA78    CXCL5: Involved in neutrophil activation. In vitro, ENA-78(8- 78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity; CXCR chemokine receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; cell-cell signaling; positive regulation of cell proliferation; neutrophil mediated immunity; response to lipopolysaccharide; immune response; positive regulation of leukocyte chemotaxis; inflammatory response; chemotaxis; signal transduction
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 Research Articles on ENA78    1. our data showed that the CXCR2/CXCL5 axis contributes to EMT of HCC cells through activating PI3K/Akt/GSK-3beta/Snail signaling, and it may serve as a potential therapeutic target.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ENA78 recombinant proteinPathways associated with ENA78 recombinant protein
 Reference Product  PubMed Publications
 CXCR2 recombinant protein  >92 publications with ENA78 and CXCR2
 CCL5 recombinant protein  >80 publications with ENA78 and CCL5
 CXCL10 recombinant protein  >66 publications with ENA78 and CXCL10
 CCL20 recombinant protein  >43 publications with ENA78 and CCL20
 CXCL12 recombinant protein  >34 publications with ENA78 and CXCL12
 CXCR1 recombinant protein  >26 publications with ENA78 and CXCR1
 CXCL11 recombinant protein  >23 publications with ENA78 and CXCL11
 CXCR3 recombinant protein  >15 publications with ENA78 and CXCR3
 CXCL13 recombinant protein  >14 publications with ENA78 and CXCL13
 CCL19 recombinant protein  >8 publications with ENA78 and CCL19
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
Diseases associated with ENA78 recombinant proteinOrgans/Tissues associated with ENA78 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >252 publications with ENA78 and Inflammation
 Necrosis Antibodies  >107 publications with ENA78 and Necrosis
 Respiratory Tract Diseases Antibodies  >104 publications with ENA78 and Respiratory Tract Diseases
 Lung Diseases Antibodies  >94 publications with ENA78 and Lung Diseases
 Disease Models, Animal Antibodies  >70 publications with ENA78 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >47 publications with ENA78 and Cardiovascular Diseases
 Fibrosis Antibodies  >29 publications with ENA78 and Fibrosis
 Pneumonia Antibodies  >28 publications with ENA78 and Pneumonia
 Lung Neoplasms Antibodies  >27 publications with ENA78 and Lung Neoplasms
 Liver Diseases Antibodies  >25 publications with ENA78 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >312 publications with ENA78 and Blood
 Lung Antibodies  >140 publications with ENA78 and Lung
 Vascular Antibodies  >101 publications with ENA78 and Vascular
 Intestine Antibodies  >39 publications with ENA78 and Intestine
 Skin Antibodies  >31 publications with ENA78 and Skin
 Brain Antibodies  >19 publications with ENA78 and Brain
 Kidney Antibodies  >17 publications with ENA78 and Kidney
 Connective Tissue Antibodies  >16 publications with ENA78 and Connective Tissue
 Uterus Antibodies  >15 publications with ENA78 and Uterus
 Embryonic Tissue Antibodies  >14 publications with ENA78 and Embryonic Tissue
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