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EPO1L recombinant protein

Scan QR to view Datasheet Catalog #    MBS205679
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EPO1L, Recombinant Protein

★Popular Item★
 Also Known As   

EPO1L, 24-468aa, Human, His tag, E Coli

 Product Synonym Names    ERO1-like protein alpha; ERO1-alpha; ERO1A
 Product Gene Name   

EPO1L recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGSEEQPPET AAQRCFCQVS GYLDDCTCDV ETIDRFNNYR LFPRLQKLLE SDYFRYYKVN LKRPCPFWND ISQCGRRDCA VKPCQSDEVP DGIKSASYKY SEEANNLIEE CEQAERLGAV DESLSEETQK AVLQWTKHDD SSDNFCEADD IQSPEAEYVD LLLNPERYTG YKGPDAWKIW NVIYEENCFK PQTIKRPLNP LASGQGTSEE NTFYSWLEGL CVEKRAFYRL ISGLHASINV HLSARYLLQE TWLEKKWGHN ITEFQQRFDG ILTEGEGPRR LKNLYFLYLI ELRALSKVLP FFERPDFQLF TGNKIQDEEN KMLLLEILHE IKSFPLHFDE NSFFAGDKKE AHKLKEDFRL HFRNISRIMD CVGCFKCRLW GKLQTQGLGT ALKILFSEKL IANMPESGPS YEFHLTRQEI VSLFNAFGRI STSVKELENF RNLLQNIH
 OMIM    AF081886 mRNA
 3D Structure    ModBase 3D Structure for Q96HE7
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of EPO1L recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for EPO1L recombinant protein

   ERO1-like protein alpha, also known as EPO1L, is an essential oxidoreductase that oxidizes proteins and is required for the folding of immunoglobulins. EPO1L covalently binds with PDI (protein disulfide-isomerase) and together they produce disulfide bonds between proteins in the endoplasmic reticulum. EPO1L is stimulated by hypoxia, suggesting that it is regulated through the HIF (hypoxia inducible transcrip-tion factor) pathway. EPO1L is ubiquitously expressed at low levels but expressed at high levels in upper digestive tract and esophagus. Recombinant human EPO1L protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for EPO1L recombinant protein    Signal Transduction
 Applications Tested/Suitable for EPO1L recombinant protein   

SDS-PAGE

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 SDS-Page of EPO1L recombinant protein    EPO1L recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for EPO1L. It may not necessarily be applicable to this product.
 NCBI GI #    7657069
 NCBI GeneID    30001
 NCBI Accession #    NP_055399 [Other Products]
 NCBI GenBank Nucleotide #    NM_014584.2 [Other Products]
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 UniProt Primary Accession #    Q96HE7 [Other Products]
 UniProt Secondary Accession #    Q7LD45; Q9P1Q9; Q9UKV6; A8K9X4; A8MYW1 [Other Products]
 UniProt Related Accession #    Q96HE7 [Other Products]
 Molecular Weight    54.4 kDa (468aa)
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 NCBI Official Full Name    ERO1-like protein alpha
 NCBI Official Synonym Full Names    endoplasmic reticulum oxidoreductase 1 alpha
 NCBI Official Symbol    ERO1A [Similar Products]
 NCBI Official Synonym Symbols   
ERO1L; ERO1-L; ERO1LA; Ero1alpha; ERO1-alpha; ERO1-L-alpha
[Similar Products]
 NCBI Protein Information    ERO1-like protein alpha
 UniProt Protein Name    ERO1-like protein alpha
 UniProt Synonym Protein Names   
Endoplasmic oxidoreductin-1-like protein; Endoplasmic reticulum oxidoreductase alpha
 UniProt Gene Name    ERO1A [Similar Products]
 UniProt Synonym Gene Names    ERO1-L; ERO1-L-alpha [Similar Products]
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 UniProt Comments for EPO1L    Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1.
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Product References and Citations for EPO1L recombinant protein

   Otsu M., et al. (2006) Antioxid. Redox Signal. 8: 274-282.; Gess B., et al. (2003) J Biochem. 270: 2228-2235.;
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 Research Articles on EPO1L    1. High expression of ERO1L is associated with poor prognosis of patients with gastric cancer. These results indicate that ERO1L expression may be a clinically promising therapeutic target for prevention of gastric cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with EPO1L recombinant proteinPathways associated with EPO1L recombinant protein
 Reference Product  PubMed Publications
 ERO1L recombinant protein  >2 publications with EPO1L and ERO1L
 Products by Pathway  Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Detoxification Of Reactive Oxygen Species Pathway antibodies  Detoxification Of Reactive Oxygen Species Pathway Diagram
 Insulin Processing Pathway antibodies  Insulin Processing Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Vibrio Cholerae Infection Pathway antibodies  Vibrio Cholerae Infection Pathway Diagram
 Vibrio Cholerae Infection Pathway antibodies  Vibrio Cholerae Infection Pathway Diagram
Diseases associated with EPO1L recombinant proteinOrgans/Tissues associated with EPO1L recombinant protein
 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >1 publications with EPO1L and Insulin Resistance
 Cardiovascular Diseases Antibodies  >1 publications with EPO1L and Cardiovascular Diseases
 Heart Diseases Antibodies  >1 publications with EPO1L and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >1 publications with EPO1L and Heart
 Lymph Node Antibodies  >1 publications with EPO1L and Lymph Node
 Pancreas Antibodies  >1 publications with EPO1L and Pancreas
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