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PI3 recombinant protein :: Elafin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS952480
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $785 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $990 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,025 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,440 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,570 +1 FREE 8GB USB
1 mg (Baculovirus)  /  $1,935 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Elafin (PI3), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Elafin

 Product Synonym Names    Elastase-specific inhibitor; ESI; Peptidase inhibitor 3; PI-3; Protease inhibitor WAP3; Skin-derived antileukoproteinase; SKALPWAP four-disulfide core domain protein 14
 Product Gene Name   

PI3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    61-117aa; Full Length
 Sequence    AQEPVKGPVS TKPGSCPIIL IRCAMLNPPN RCLKDTDCPG IKKCCEGSCG MACFVPQ
 OMIM    182257
 3D Structure    ModBase 3D Structure for P19957
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PI3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for PI3 recombinant protein

   Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.
 Product Categories/Family for PI3 recombinant protein    Signal Transduction
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 SDS-PAGE of PI3 recombinant protein    PI3 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for PI3. It may not necessarily be applicable to this product.
 NCBI GI #    4505787
 NCBI GeneID    5266
 NCBI Accession #    NP_002629.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002638.3 [Other Products]
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 UniProt Primary Accession #    P19957 [Other Products]
 UniProt Secondary Accession #    Q6FG74; E1P618 [Other Products]
 UniProt Related Accession #    P19957 [Other Products]
 Molecular Weight    22.01kD
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 NCBI Official Full Name    elafin preproprotein
 NCBI Official Synonym Full Names    peptidase inhibitor 3
 NCBI Official Symbol    PI3 [Similar Products]
 NCBI Official Synonym Symbols   
ESI; WAP3; SKALP; WFDC14; cementoin
[Similar Products]
 NCBI Protein Information    elafin
 UniProt Protein Name    Elafin
 UniProt Synonym Protein Names   
Elastase-specific inhibitor; ESI; Peptidase inhibitor 3; PI-3; Protease inhibitor WAP3; Skin-derived antileukoproteinase; SKALP; WAP four-disulfide core domain protein 14
 Protein Family    Elafin
 UniProt Gene Name    PI3 [Similar Products]
 UniProt Synonym Gene Names    WAP3; WFDC14; ESI; PI-3; SKALP [Similar Products]
 UniProt Entry Name    ELAF_HUMAN
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 NCBI Summary for PI3    This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]
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 UniProt Comments for PI3    elafin: Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.

Protein type: Secreted; Extracellular matrix; Inhibitor; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: proteinaceous extracellular matrix

Molecular Function: endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity

Biological Process: copulation
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Product References and Citations for PI3 recombinant protein

   Primary structure of the human elafin precursor preproelafin deduced from the nucleotide sequence of its gene and the presence of unique repetitive sequences in the prosegment.Saheki T., Ito F., Hagiwara H., Saito Y., Kuroki J., Tachibana S., Hirose S.Biochem. Biophys. Res. Commun. 185:240-245(1992)
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 Research Articles on PI3    1. The expression of elafin in fallopian tubes of ectopic pregnancies is reduced.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PI3 recombinant proteinDiseases associated with PI3 recombinant protein
 Reference Product  PubMed Publications
 AKT1 recombinant protein  >470 publications with PI3 and AKT1
 PTEN recombinant protein  >305 publications with PI3 and PTEN
 CTNNB1 recombinant protein  >83 publications with PI3 and CTNNB1
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >398 publications with PI3 and Cardiovascular Diseases
 Necrosis Antibodies  >301 publications with PI3 and Necrosis
 Inflammation Antibodies  >293 publications with PI3 and Inflammation
 Nervous System Diseases Antibodies  >259 publications with PI3 and Nervous System Diseases
 Breast Neoplasms Antibodies  >218 publications with PI3 and Breast Neoplasms
 Gastrointestinal Diseases Antibodies  >138 publications with PI3 and Gastrointestinal Diseases
 Cell Transformation, Neoplastic Antibodies  >135 publications with PI3 and Cell Transformation, Neoplastic
 Lung Diseases Antibodies  >127 publications with PI3 and Lung Diseases
 Atherosclerosis Antibodies  >88 publications with PI3 and Atherosclerosis
 Neoplasms, Experimental Antibodies  >84 publications with PI3 and Neoplasms, Experimental
Organs/Tissues associated with PI3 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1002 publications with PI3 and Blood
 Muscle Antibodies  >707 publications with PI3 and Muscle
 Brain Antibodies  >570 publications with PI3 and Brain
 Lung Antibodies  >254 publications with PI3 and Lung
 Prostate Antibodies  >122 publications with PI3 and Prostate
 Skin Antibodies  >109 publications with PI3 and Skin
 Intestine Antibodies  >94 publications with PI3 and Intestine
 Ovary Antibodies  >64 publications with PI3 and Ovary
 Adipose Tissue Antibodies  >64 publications with PI3 and Adipose Tissue
 Thyroid Antibodies  >50 publications with PI3 and Thyroid
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