NP_031378.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Predicted Molecular Mass: 27.6kDa Accurate Molecular Mass: 27kDa as determined by SDS-PAGE reducing conditions.
NCBI Official Full Name
chymotrypsin-like elastase family member 3B preproprotein
NCBI Official Synonym Full Names
chymotrypsin-like elastase family, member 3B
NCBI Protein Information
chymotrypsin-like elastase family member 3B; elastase 1; protease E; elastase-3B; proteinase E; elastase IIIB; fecal elastase 1; pancreatic elastase 1; elastase 3B, pancreatic; pancreatic endopeptidase E; cholesterol-binding pancreatic protease
UniProt Protein Name
Chymotrypsin-like elastase family member 3B
UniProt Synonym Protein Names
Elastase IIIB; Elastase-3B; Protease E
UniProt Synonym Gene Names
UniProt Entry Name
CEL3B_HUMAN
NCBI Summary for ELA3B
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009]
UniProt Comments for ELA3B
CELA3B: Efficient protease with alanine specificity but only little elastolytic activity. Belongs to the peptidase S1 family. Elastase subfamily.
Protein type: Protease; EC 3.4.21.70
Chromosomal Location of Human Ortholog: 1p36.12
Molecular Function: peptidase activity; serine-type endopeptidase activity
Biological Process: cholesterol metabolic process; proteolysis
Research Articles on ELA3B
Precautions
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Pathways associated with ELA3B recombinant protein
Organs/Tissues associated with ELA3B recombinant protein
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