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Erap1 recombinant protein :: Endoplasmic reticulum aminopeptidase 1 (Erap1), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1361542
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $170 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $255 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $400 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $640 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,000 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Endoplasmic reticulum aminopeptidase 1 (Erap1), partial, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Endoplasmic reticulum aminopeptidase 1 (Erap1), partial

 Product Synonym Names    Endoplasmic reticulum aminopeptidase 1; EC=3.4.11.-; ARTS-1; Adipocyte-derived leucine aminopeptidase; A-LAP; Aminopeptidase PILS; Puromycin-insensitive leucyl-specific aminopeptidase; PILS-AP; VEGF-induced aminopeptidase
 Product Gene Name   

Erap1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    Erap1; Appils; Arts1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS1361542 COA    COA PDF
 Sequence Positions    731-930aa; Partial
 Sequence    PCVQRAERYF REWKSSNGNM SIPIDVTLAV FAVGAQNTEG WDFLYSKYQS SLSSTEKSQI EFSLCTSKDP EKLQWLLDQS FKGEIIKTQE FPHILTLIGR NPVGYPLAWK FLRENWNKLV QKFELGSSSI AHMVMGTTDQ FSTRARLEEV KGFFSSLKEN GSQLRCVQQT IETIEENIRW MDKNFDKIRL WLQKEKPELL
 3D Structure    ModBase 3D Structure for Q9EQH2
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Erap1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Erap1 recombinant protein

   Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney (By similarity).
 Product Categories/Family for Erap1 recombinant protein    Immunology
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 SDS-PAGE of Erap1 recombinant protein    Erap1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Erap1. It may not necessarily be applicable to this product.
 NCBI GI #    13507656
 NCBI GeneID    80898
 NCBI Accession #    NP_109636.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_030711.4 [Other Products]
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 UniProt Primary Accession #    Q9EQH2 [Other Products]
 UniProt Secondary Accession #    Q6GTP5; Q9ET63 [Other Products]
 UniProt Related Accession #    Q9EQH2 [Other Products]
 Molecular Weight    106,599 Da
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 NCBI Official Full Name    endoplasmic reticulum aminopeptidase 1
 NCBI Official Synonym Full Names    endoplasmic reticulum aminopeptidase 1
 NCBI Official Symbol    Erap1 [Similar Products]
 NCBI Official Synonym Symbols   
Arts1; ERAAP; PILSA; PILSAP
[Similar Products]
 NCBI Protein Information    endoplasmic reticulum aminopeptidase 1; A-LAP; ARTS-1; PILS-AP; aminopeptidase PILS; VEGF-induced aminopeptidase; adipocyte-derived leucine aminopeptidase; puromycin-insensitive leucyl-specific aminopeptidase; type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
 UniProt Protein Name    Endoplasmic reticulum aminopeptidase 1
 UniProt Synonym Protein Names   
ARTS-1; Adipocyte-derived leucine aminopeptidase; A-LAP; Aminopeptidase PILS; Puromycin-insensitive leucyl-specific aminopeptidase; PILS-AP; VEGF-induced aminopeptidase
 Protein Family    Endoplasmic reticulum aminopeptidase
 UniProt Gene Name    Erap1 [Similar Products]
 UniProt Synonym Gene Names    Appils; Arts1; A-LAP; PILS-AP [Similar Products]
 UniProt Entry Name    ERAP1_MOUSE
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 UniProt Comments for Erap1    ARTS1: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. Belongs to the peptidase M1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.11.-; Membrane protein, integral; Protease

Cellular Component: extracellular space; intracellular membrane-bound organelle; membrane; endoplasmic reticulum lumen; endoplasmic reticulum; cytoplasm; integral to membrane; extracellular region

Molecular Function: peptidase activity; interleukin-6 receptor binding; metalloexopeptidase activity; metallopeptidase activity; hydrolase activity; zinc ion binding; metal ion binding; aminopeptidase activity; tumor necrosis factor receptor binding

Biological Process: positive regulation of angiogenesis; immune system process; membrane protein ectodomain proteolysis; proteolysis
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 Research Articles on Erap1    1. These results suggest that secretion of ERAP1 is mediated by toll-like receptors via induction of intermediate cytokines
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Erap1 recombinant proteinDiseases associated with Erap1 recombinant protein
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Disease Name  Pubmed Publications
 Spondylitis, Ankylosing Antibodies  >69 publications with Erap1 and Spondylitis, Ankylosing
 Musculoskeletal Diseases Antibodies  >63 publications with Erap1 and Musculoskeletal Diseases
 Psoriasis Antibodies  >32 publications with Erap1 and Psoriasis
 Immune System Diseases Antibodies  >17 publications with Erap1 and Immune System Diseases
 Necrosis Antibodies  >15 publications with Erap1 and Necrosis
 Inflammation Antibodies  >7 publications with Erap1 and Inflammation
 Nervous System Diseases Antibodies  >4 publications with Erap1 and Nervous System Diseases
 Behcet Syndrome Antibodies  >3 publications with Erap1 and Behcet Syndrome
 Kidney Diseases Antibodies  >2 publications with Erap1 and Kidney Diseases
 Cell Transformation, Neoplastic Antibodies  >2 publications with Erap1 and Cell Transformation, Neoplastic
Organs/Tissues associated with Erap1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >7 publications with Erap1 and Skin
 Bone Antibodies  >5 publications with Erap1 and Bone
 Lung Antibodies  >4 publications with Erap1 and Lung
 Heart Antibodies  >3 publications with Erap1 and Heart
 Lymph Node Antibodies  >3 publications with Erap1 and Lymph Node
 Liver Antibodies  >3 publications with Erap1 and Liver
 Connective Tissue Antibodies  >1 publications with Erap1 and Connective Tissue
 Ovary Antibodies  >1 publications with Erap1 and Ovary
 Eye Antibodies  >1 publications with Erap1 and Eye
 Kidney Antibodies  >1 publications with Erap1 and Kidney
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