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Hspa5 recombinant protein :: Endoplasmic reticulum chaperone BiP (Hspa5) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS718537
SDS-Page
Unit / Price
0.01 mg (Yeast)  /  $225 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $290 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $495 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $795 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $1,060 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,235 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,305 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,430 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,485 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,565 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,580 +1 FREE 8GB USB
1 mg (Yeast)  /  $2,065 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,235 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,235 +2 FREE 8GB USB
1 mg (E-Coli)  /  $2,250 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,930 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Endoplasmic reticulum chaperone BiP (Hspa5), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Endoplasmic reticulum chaperone BiP (Hspa5)

 Product Gene Name   

Hspa5 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS718537 COA    COA PDF
 Sequence Positions    20-655. Full length of the mature protein.
 Sequence    EEEDKKEDVG TVVGIDLGTT YSCVGVFKNG RVEIIANDQG NRITPSYVAF TPEGERLIGD AAKNQLTSNP ENTVFDAKRL IGRTWNDPSV QQDIKFLPFK VVEKKTKPYI QVDIGGGQTK TFAPEEISAM VLTKMKETAE AYLGKKVTHA VVTVPAYFND AQRQATKDAG TIAGLNVMRI INEPTAAAIA YGLDKREGEK NILVFDLGGG TFDVSLLTID NGVFEVVATN GDTHLGGEDF DQRVMEHFIK LYKKKTGKDV RKDNRAVQKL RREVEKAKRA LSSQHQARIE IESFFEGEDF SETLTRAKFE ELNMDLFRST MKPVQKVLED SDLKKSDIDE IVLVGGSTRI PKIQQLVKEF FNGKEPSRGI NPDEAVAYGA AVQAGVLSGD QDTGDLVLLD VCPLTLGIET VGGVMTKLIP RNTVVPTKKS QIFSTASDNQ PTVTIKVYEG ERPLTKDNHL LGTFDLTGIP PAPRGVPQIE VTFEIDVNGI LRVTAEDKGT GNKNKITITN DQNRLTPEEI ERMVNDAEKF AEEDKKLKER IDTRNELESY AYSLKNQIGD KEKLGGKLSS EDKETMEKAV EEKIEWLESH QDADIEDFKA KKKELEEIVQ PIISKLYGSG GPPPTGEEDT SEKDEL
 3D Structure    ModBase 3D Structure for P20029
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mouse
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Hspa5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 SDS-Page of Hspa5 recombinant protein    Hspa5 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Hspa5. It may not necessarily be applicable to this product.
 NCBI GI #    254540168
 NCBI GeneID    14828
 NCBI Accession #    NP_001156906.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001163434.1 [Other Products]
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 UniProt Primary Accession #    P20029 [Other Products]
 UniProt Secondary Accession #    O35642; Q3UFF2; Q61630 [Other Products]
 UniProt Related Accession #    P20029 [Other Products]
 Molecular Weight    72,422 Da
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 NCBI Official Full Name    78 kDa glucose-regulated protein
 NCBI Official Synonym Full Names    heat shock protein 5
 NCBI Official Symbol    Hspa5 [Similar Products]
 NCBI Official Synonym Symbols   
Bip; Sez7; mBiP; Grp78; SEZ-7; Hsce70; baffled; AL022860; AU019543; D2Wsu17e; D2Wsu141e
[Similar Products]
 NCBI Protein Information    78 kDa glucose-regulated protein
 UniProt Protein Name    Endoplasmic reticulum chaperone BiP
 UniProt Synonym Protein Names   
78 kDa glucose-regulated protein
 UniProt Gene Name    Hspa5 [Similar Products]
 UniProt Synonym Gene Names    HSP70 family protein 5Curated [Similar Products]
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 UniProt Comments for Hspa5    Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:12411443, PubMed:12475965). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (PubMed:12411443). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 ().
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 Research Articles on Hspa5    1. analysis of the effects of triptolide on cell proliferation, cell cycle and the expression of GRP78 in nasopharyngeal carcinoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Hspa5 recombinant proteinPathways associated with Hspa5 recombinant protein
 Reference Product  PubMed Publications
 Atf6 recombinant protein  >43 publications with Hspa5 and Atf6
 Ern1 recombinant protein  >12 publications with Hspa5 and Ern1
 Hsp90b1 recombinant protein  >12 publications with Hspa5 and Hsp90b1
 Ern2 recombinant protein  >8 publications with Hspa5 and Ern2
 Hsp90aa1 recombinant protein  >6 publications with Hspa5 and Hsp90aa1
 Hsp90ab1 recombinant protein  >4 publications with Hspa5 and Hsp90ab1
 Products by Pathway  Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Prion Diseases Pathway antibodies  Prion Diseases Pathway Diagram
 Prion Diseases Pathway antibodies  Prion Diseases Pathway Diagram
 Protein Export Pathway antibodies  Protein Export Pathway Diagram
 Protein Export Pathway antibodies  Protein Export Pathway Diagram
Diseases associated with Hspa5 recombinant proteinOrgans/Tissues associated with Hspa5 recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >92 publications with Hspa5 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >87 publications with Hspa5 and Disease Models, Animal
 Nervous System Diseases Antibodies  >86 publications with Hspa5 and Nervous System Diseases
 Inflammation Antibodies  >47 publications with Hspa5 and Inflammation
 Heart Diseases Antibodies  >32 publications with Hspa5 and Heart Diseases
 Necrosis Antibodies  >31 publications with Hspa5 and Necrosis
 Liver Diseases Antibodies  >30 publications with Hspa5 and Liver Diseases
 Kidney Diseases Antibodies  >18 publications with Hspa5 and Kidney Diseases
 Obesity Antibodies  >14 publications with Hspa5 and Obesity
 Fibrosis Antibodies  >14 publications with Hspa5 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >110 publications with Hspa5 and Brain
 Muscle Antibodies  >75 publications with Hspa5 and Muscle
 Blood Antibodies  >69 publications with Hspa5 and Blood
 Heart Antibodies  >60 publications with Hspa5 and Heart
 Liver Antibodies  >53 publications with Hspa5 and Liver
 Kidney Antibodies  >45 publications with Hspa5 and Kidney
 Artery Antibodies  >30 publications with Hspa5 and Artery
 Pancreas Antibodies  >24 publications with Hspa5 and Pancreas
 Lung Antibodies  >23 publications with Hspa5 and Lung
 Ovary Antibodies  >15 publications with Hspa5 and Ovary
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