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EDF1 recombinant protein :: Endothelial Differentiation-Related Factor 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143978 EDF1 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Endothelial Differentiation-Related Factor 1 (EDF1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Endothelial Differentiation-Related Factor 1

 Product Synonym Names    EDF1 Human; Endothelial Differentiation-Related Factor 1 Human Recombinant; EDF-1; MBF1; Multiprotein-bridging factor 1
 Product Gene Name   

EDF1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MAESDWDTVT VLRKKGPTAA QAKSKQAILA AQRRGEDVET SKKWAAGQNK QHSITKNTAK LDRETEELHH DRVTLEVGKV IQQGRQSKGL TQKDLATKIN EKPQVIADYE SGRAIPNNQV LGKIERAIGL KLRGKDIGKP IEKGPRAKLE HHHHHH
 OMIM    605107
 3D Structure    ModBase 3D Structure for O60869
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 Host    E Coli
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 Purity/Purification    Greater than 90.0% as determined by SDS-PAGE.
 Form/Format    0.5 mg/ml solution containing 20mM Tris pH-8, 1mM DTT, 0.1M NaCl & 20% glycerol.
Sterile filtered colorless solution.
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 Preparation and Storage    EDF1 Human although stable at 4C for 1 week, should be stored desiccated below -18C. Please prevent freeze thaw cycles.
 Other Notes    Small volumes of EDF1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for EDF1 recombinant protein

   Description: EDF1 Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 156 amino acids (1-148 a.a.) and having a molecular mass of 17.4 kDa. The EDF1 is fused to 8 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.

Introduction: EDF1 controls endothelial cell differentiation. EDF1 has a role as a bridging protein that interconnects regulatory proteins and the basal transcriptional machinery, thus modulating the transcription of genes that take part in endothelial differentiation. EDF1 binds calmodulin through its IQ domain and controls nitric oxide synthase activity via calmodulin sequestration in the cytoplasm. EDF1 is localized in adult liver, heart, adipose tissues, intestine and pancreas.
 Product Categories/Family for EDF1 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for EDF1. It may not necessarily be applicable to this product.
 NCBI GI #    526253086
 NCBI GeneID    8721
 NCBI Accession #    NP_001268226.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001281297.1 [Other Products]
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 UniProt Primary Accession #    O60869 [Other Products]
 UniProt Secondary Accession #    Q5T5T2; Q9UIM1 [Other Products]
 UniProt Related Accession #    O60869 [Other Products]
 Molecular Weight    15,636 Da
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 NCBI Official Full Name    endothelial differentiation-related factor 1 isoform 3
 NCBI Official Synonym Full Names    endothelial differentiation-related factor 1
 NCBI Official Symbol    EDF1 [Similar Products]
 NCBI Official Synonym Symbols   
MBF1; EDF-1
[Similar Products]
 NCBI Protein Information    endothelial differentiation-related factor 1; multiprotein bridging factor 1
 UniProt Protein Name    Endothelial differentiation-related factor 1
 UniProt Synonym Protein Names   
Multiprotein-bridging factor 1; MBF1
 Protein Family    Endothelial differentiation-related factor
 UniProt Gene Name    EDF1 [Similar Products]
 UniProt Synonym Gene Names    EDF-1; MBF1 [Similar Products]
 UniProt Entry Name    EDF1_HUMAN
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 NCBI Summary for EDF1    This gene encodes a protein that may regulate endothelial cell differentiation, lipid metabolism, and hormone-induced cardiomyocyte hypertrophy. The encoded protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
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 UniProt Comments for EDF1    EDF1: Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: transcription factor TFIID complex; cytoplasm; nucleolus; intracellular; nucleus

Molecular Function: calmodulin binding; methyltransferase activity; protein binding; histone acetyltransferase activity; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity

Biological Process: endothelial cell differentiation; regulation of lipid metabolic process; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; multicellular organismal development; positive regulation of DNA binding
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 Research Articles on EDF1    1. According to this study multiprotein bridging factor 1 and Calmodulin do not interact in vitro as confirmed by NMR spectroscopy and CaM-agarose affinity chromatography.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with EDF1 recombinant proteinDiseases associated with EDF1 recombinant protein
 Reference Product  PubMed Publications
 JUN recombinant protein  >8 publications with EDF1 and JUN
 TBP recombinant protein  >6 publications with EDF1 and TBP
 NR5A1 recombinant protein  >1 publications with EDF1 and NR5A1
 NR5A2 recombinant protein  >1 publications with EDF1 and NR5A2
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >2 publications with EDF1 and Breast Neoplasms
 Brain Diseases Antibodies  >1 publications with EDF1 and Brain Diseases
 Gonadal Disorders Antibodies  >1 publications with EDF1 and Gonadal Disorders
 Mental Disorders Antibodies  >1 publications with EDF1 and Mental Disorders
 Ovarian Diseases Antibodies  >1 publications with EDF1 and Ovarian Diseases
 Cardiovascular Diseases Antibodies  >1 publications with EDF1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >1 publications with EDF1 and Heart Diseases
 Hypertrophy Antibodies  >1 publications with EDF1 and Hypertrophy
Organs/Tissues associated with EDF1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >8 publications with EDF1 and Vascular
 Embryonic Tissue Antibodies  >3 publications with EDF1 and Embryonic Tissue
 Umbilical Cord Antibodies  >2 publications with EDF1 and Umbilical Cord
 Brain Antibodies  >2 publications with EDF1 and Brain
 Bone Antibodies  >1 publications with EDF1 and Bone
 Ovary Antibodies  >1 publications with EDF1 and Ovary
 Muscle Antibodies  >1 publications with EDF1 and Muscle
 Heart Antibodies  >1 publications with EDF1 and Heart
 Liver Antibodies  >1 publications with EDF1 and Liver
 Skin Antibodies  >1 publications with EDF1 and Skin
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