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Epas1 recombinant protein :: Endothelial PAS domain-containing protein 1 (Epas1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS957231 Epas1 recombinant protein
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Endothelial PAS domain-containing protein 1 (Epas1), Recombinant Protein

 Also Known As   

Recombinant Mouse Endothelial PAS domain-containing protein 1 (Epas1) , partial

 Product Gene Name   

Epas1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P97481
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mouse
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Epas1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Epas1 recombinant protein

   This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.
NCBI/Uniprot data below describe general gene information for Epas1. It may not necessarily be applicable to this product.
 NCBI GI #    178057356
 NCBI GeneID    13819
 NCBI Accession #    NP_034267.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_010137.3 [Other Products]
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 UniProt Primary Accession #    P97481 [Other Products]
 UniProt Secondary Accession #    O08787; O55046 [Other Products]
 UniProt Related Accession #    P97481 [Other Products]
 Molecular Weight    96,712 Da
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 NCBI Official Full Name    endothelial PAS domain-containing protein 1
 NCBI Official Synonym Full Names    endothelial PAS domain protein 1
 NCBI Official Symbol    Epas1 [Similar Products]
 NCBI Official Synonym Symbols   
HLF; HRF; MOP2; HIF2A; bHLHe73; HIF-2alpha
[Similar Products]
 NCBI Protein Information    endothelial PAS domain-containing protein 1
 UniProt Protein Name    Endothelial PAS domain-containing protein 1
 UniProt Synonym Protein Names   
HIF-1-alpha-like factor; HLF; mHLF; HIF-related factor; HRF; Hypoxia-inducible factor 2-alpha; HIF-2-alpha; HIF2-alpha
 Protein Family    Endothelial PAS domain-containing protein
 UniProt Gene Name    Epas1 [Similar Products]
 UniProt Synonym Gene Names    Hif2a; EPAS-1; HLF; mHLF; HRF; HIF-2-alpha; HIF2-alpha [Similar Products]
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 UniProt Comments for Epas1    Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD ().
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 Research Articles on Epas1    1. Data suggest that chronic hypoxia enhances HIF-2alpha stability, which causes increased arginase expression and dysregulates normal vascular NO homeostasis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Epas1 recombinant proteinPathways associated with Epas1 recombinant protein
 Reference Product  PubMed Publications
 Vhl recombinant protein  >32 publications with Epas1 and Vhl
 Egln1 recombinant protein  >31 publications with Epas1 and Egln1
 Vegfa recombinant protein  >13 publications with Epas1 and Vegfa
 Egln2 recombinant protein  >2 publications with Epas1 and Egln2
 Pou5f1 recombinant protein  >1 publications with Epas1 and Pou5f1
 Egln3 recombinant protein  >1 publications with Epas1 and Egln3
 Products by Pathway  Pathway Diagram
 Adipogenesis Genes Pathway antibodies  Adipogenesis Genes Pathway Diagram
 Cellular Response To Hypoxia Pathway antibodies  Cellular Response To Hypoxia Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Focal Adhesion-PI3K-Akt-mTOR-signaling Pathway antibodies  Focal Adhesion-PI3K-Akt-mTOR-signaling Pathway Diagram
 Oxygen-dependent Asparagine Hydroxylation Of Hypoxia-inducible Factor Alpha Pathway antibodies  Oxygen-dependent Asparagine Hydroxylation Of Hypoxia-inducible Factor Alpha Pathway Diagram
 Oxygen-dependent Proline Hydroxylation Of Hypoxia-inducible Factor Alpha Pathway antibodies  Oxygen-dependent Proline Hydroxylation Of Hypoxia-inducible Factor Alpha Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 PodNet: Protein-protein Interactions In The Podocyte Pathway antibodies  PodNet: Protein-protein Interactions In The Podocyte Pathway Diagram
 Regulation Of Hypoxia-inducible Factor (HIF) By Oxygen Pathway antibodies  Regulation Of Hypoxia-inducible Factor (HIF) By Oxygen Pathway Diagram
 Regulation Of Gene Expression By Hypoxia-inducible Factor Pathway antibodies  Regulation Of Gene Expression By Hypoxia-inducible Factor Pathway Diagram
Diseases associated with Epas1 recombinant proteinOrgans/Tissues associated with Epas1 recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma, Renal Cell Antibodies  >16 publications with Epas1 and Carcinoma, Renal Cell
 Disease Models, Animal Antibodies  >14 publications with Epas1 and Disease Models, Animal
 Lung Diseases Antibodies  >11 publications with Epas1 and Lung Diseases
 Kidney Diseases Antibodies  >10 publications with Epas1 and Kidney Diseases
 Inflammation Antibodies  >9 publications with Epas1 and Inflammation
 Necrosis Antibodies  >7 publications with Epas1 and Necrosis
 Hypertension Antibodies  >7 publications with Epas1 and Hypertension
 Lung Neoplasms Antibodies  >6 publications with Epas1 and Lung Neoplasms
 Hypertrophy Antibodies  >5 publications with Epas1 and Hypertrophy
 Neoplasms, Experimental Antibodies  >5 publications with Epas1 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >48 publications with Epas1 and Blood
 Kidney Antibodies  >20 publications with Epas1 and Kidney
 Lung Antibodies  >20 publications with Epas1 and Lung
 Heart Antibodies  >18 publications with Epas1 and Heart
 Liver Antibodies  >16 publications with Epas1 and Liver
 Muscle Antibodies  >11 publications with Epas1 and Muscle
 Brain Antibodies  >11 publications with Epas1 and Brain
 Adrenal Gland Antibodies  >11 publications with Epas1 and Adrenal Gland
 Embryonic Tissue Antibodies  >11 publications with Epas1 and Embryonic Tissue
 Eye Antibodies  >5 publications with Epas1 and Eye
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