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EDN1 recombinant protein :: Endothelin 1 (EDN1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2018815 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $135 +1 FREE 8GB USB
0.05 mg  /  $250 +1 FREE 8GB USB
0.1 mg  /  $385 +1 FREE 8GB USB
0.2 mg  /  $470 +1 FREE 8GB USB
0.5 mg  /  $910 +1 FREE 8GB USB
1 mg  /  $1,345 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Endothelin 1 (EDN1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Endothelin 1 (EDN1)

 Product Gene Name   

EDN1 recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Endothelin 1 (EDN1) (MBS2013568)
Antigen: Endothelin 1 (EDN1) (MBS2018815)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with N-terminal His-Tag, its sequence is listed below.
 Chromosome Location    Chromosome: 13; NC_000079.6 (42301270..42307989). Location: 13 A4; 13 20.82 cM
 3D Structure    ModBase 3D Structure for P22387
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Mus musculus (Mouse)
 Expression System    Prokaryotic expression
 Residues    Glu33~His202 (Accession # P22387) with N-terminal His-Tag
 Subcellular Location    Secreted
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Predicted Isoelectric Point    9.9
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of EDN1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for EDN1 recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for EDN1 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-PAGE of EDN1 recombinant protein    EDN1 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for EDN1. It may not necessarily be applicable to this product.
 NCBI GI #    6753720
 NCBI GeneID    13614
 NCBI Accession #    NP_034234.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_010104.3 [Other Products]
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 UniProt Primary Accession #    P22387 [Other Products]
 UniProt Secondary Accession #    P70203; P97338 [Other Products]
 UniProt Related Accession #    P22387 [Other Products]
 Molecular Weight    21.0kDa
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 NCBI Official Full Name    endothelin-1
 NCBI Official Synonym Full Names    endothelin 1
 NCBI Official Symbol    Edn1 [Similar Products]
 NCBI Official Synonym Symbols   
ET-1; preproET
[Similar Products]
 NCBI Protein Information    endothelin-1; PPET1; preproendothelin; preproendothelin-1
 UniProt Protein Name    Endothelin-1
 UniProt Synonym Protein Names   
 Protein Family    Endothelin
 UniProt Gene Name    Edn1 [Similar Products]
 UniProt Synonym Gene Names    ET-1; PPET1 [Similar Products]
 UniProt Entry Name    EDN1_MOUSE
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 UniProt Comments for EDN1    EDN1: Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family.

Protein type: Secreted, signal peptide; Secreted

Cellular Component: extracellular space; cell; cytoplasm; extracellular region; cytosol

Molecular Function: protein binding; hormone activity; endothelin B receptor binding; cytokine activity; endothelin A receptor binding; receptor binding

Biological Process: positive regulation of JNK activity; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of systemic arterial blood pressure by endothelin; heart development; middle ear morphogenesis; prostaglandin biosynthetic process; sensory perception of pain; positive regulation of MAP kinase activity; elevation of cytosolic calcium ion concentration; negative regulation of cAMP biosynthetic process; cell surface receptor linked signal transduction; cell-cell signaling; negative regulation of nitric-oxide synthase biosynthetic process; protein kinase C activation; regulation of blood vessel size; cell growth; rhythmic excitation; positive regulation of mitosis; positive regulation of heart rate; respiratory gaseous exchange; peptide hormone secretion; patterning of blood vessels; membrane depolarization; protein kinase C deactivation; regulation of vasoconstriction; blood vessel morphogenesis; positive regulation of transcription from RNA polymerase II promoter; superoxide release; positive regulation of odontogenesis; epithelial fluid transport; phosphoinositide 3-kinase cascade; G-protein signaling, phospholipase D activating pathway; positive regulation of cell size; neural crest cell development; negative regulation of hormone secretion; positive regulation of smooth muscle cell proliferation; negative regulation of cellular protein metabolic process; glucose transport; negative regulation of transcription from RNA polymerase II promoter; vein smooth muscle contraction; histamine secretion; nitric oxide transport; regulation of blood pressure; positive regulation of cell proliferation; regulation of pH; positive regulation of smooth muscle contraction; skeletal development; artery smooth muscle contraction; vasoconstriction; inositol phosphate-mediated signaling; in utero embryonic development; calcium-mediated signaling; positive regulation of hormone secretion; body fluid secretion; G-protein coupled receptor protein signaling pathway; dorsal/ventral pattern formation; cartilage development; positive regulation of prostaglandin secretion; response to hypoxia; regulation of sensory perception of pain; positive regulation of cell migration
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 Research Articles on EDN1    1. the present studies establish an essential role of EDN1 in epidermal keratinocytes to mediate ultraviolet rays-induced melanocyte homeostasis in vivo.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with EDN1 recombinant proteinDiseases associated with EDN1 recombinant protein
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 Melanogenesis Pathway antibodies  Melanogenesis Pathway Diagram
 Melanogenesis Pathway antibodies  Melanogenesis Pathway Diagram
 MicroRNAs In Cardiomyocyte Hypertrophy Pathway antibodies  MicroRNAs In Cardiomyocyte Hypertrophy Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >32 publications with EDN1 and Cardiovascular Diseases
 Hypertension Antibodies  >28 publications with EDN1 and Hypertension
 Craniofacial Abnormalities Antibodies  >17 publications with EDN1 and Craniofacial Abnormalities
 Inflammation Antibodies  >17 publications with EDN1 and Inflammation
 Asthma Antibodies  >13 publications with EDN1 and Asthma
 Necrosis Antibodies  >7 publications with EDN1 and Necrosis
 Cardiovascular Abnormalities Antibodies  >7 publications with EDN1 and Cardiovascular Abnormalities
 Kidney Diseases Antibodies  >6 publications with EDN1 and Kidney Diseases
 Heart Defects, Congenital Antibodies  >5 publications with EDN1 and Heart Defects, Congenital
 Heart Failure Antibodies  >4 publications with EDN1 and Heart Failure
Organs/Tissues associated with EDN1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Other Antibodies  >48 publications with EDN1 and Other
 Embryonic Tissue Antibodies  >23 publications with EDN1 and Embryonic Tissue
 Heart Antibodies  >22 publications with EDN1 and Heart
 Skin Antibodies  >13 publications with EDN1 and Skin
 Lung Antibodies  >13 publications with EDN1 and Lung
 Brain Antibodies  >12 publications with EDN1 and Brain
 Connective Tissue Antibodies  >8 publications with EDN1 and Connective Tissue
 Eye Antibodies  >5 publications with EDN1 and Eye
 Bone Marrow Antibodies  >4 publications with EDN1 and Bone Marrow
 Intestine Antibodies  >3 publications with EDN1 and Intestine
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