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CCL11 recombinant protein :: Eotaxin protein (CCL11) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS969208
SDS-PAGE
Unit / Price
0.005 mg  /  $115 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $430 +1 FREE 8GB USB
0.25 mg  /  $725 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Eotaxin protein (CCL11), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Eotaxin protein (CCL11) (Active)

 Product Synonym Names    C-C motif chemokine 11; Small-inducible cytokine A11
 Product Gene Name   

CCL11 recombinant protein

[Similar Products]
 Product Synonym Gene Name    SCYA11 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    24-97aa, Full Length of Mature Protein
 Sequence    GPASVPTTCC FNLANRKIPL QRLESYRRIT SGKCPQKAVI FKTKLAKDIC ADPKKKWVQD SMKYLDQKSP TPKP
 OMIM    U46573 mRNA
 3D Structure    ModBase 3D Structure for P51671
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 Host    E Coli
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 Purity/Purification    >=97% as determined by SDS-PAGE and HPLC. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
 Biological Activity    Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood eosinophils is in a concentration range of 0.1-10.0 ng/ml.
 Storage Buffer    0.2 um filtered PBS, pH 7.4,lyophilized
 Endotoxin    Less than 1.0 EU/ug as determined by LAL method.
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 Preparation and Storage    Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CCL11 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CCL11 recombinant protein

   In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.
 Product Categories/Family for CCL11 recombinant protein    Biological Active Protein; Immunology; Chemokine
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 SDS-PAGE of CCL11 recombinant protein    CCL11 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for CCL11. It may not necessarily be applicable to this product.
 NCBI GI #    4506827
 NCBI GeneID    6356
 NCBI Accession #    NP_002977.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002986.2 [Other Products]
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 UniProt Primary Accession #    P51671 [Other Products]
 UniProt Secondary Accession #    P50877; Q92490; Q92491 [Other Products]
 UniProt Related Accession #    P51671 [Other Products]
 Molecular Weight    8.4 kDa
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 NCBI Official Full Name    eotaxin
 NCBI Official Synonym Full Names    C-C motif chemokine ligand 11
 NCBI Official Symbol    CCL11 [Similar Products]
 NCBI Official Synonym Symbols   
SCYA11
[Similar Products]
 NCBI Protein Information    eotaxin
 UniProt Protein Name    Eotaxin
 UniProt Synonym Protein Names   
C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11
 Protein Family    Eotaxin
 UniProt Gene Name    CCL11 [Similar Products]
 UniProt Synonym Gene Names    SCYA11 [Similar Products]
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 NCBI Summary for CCL11    This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]
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 UniProt Comments for CCL11    CCL11: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular region; extracellular space

Molecular Function: CCR3 chemokine receptor binding; chemokine activity; protein binding; protein dimerization activity; receptor agonist activity

Biological Process: cell adhesion; cellular calcium ion homeostasis; chemotaxis; cytoskeleton organization and biogenesis; eosinophil chemotaxis; G-protein coupled receptor protein signaling pathway; inflammatory response; lymphocyte chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of actin filament polymerization; positive regulation of cell migration; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; protein amino acid phosphorylation; regulation of cell shape; response to radiation; response to virus; signal transduction

Disease: Asthma, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To
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 Research Articles on CCL11    1. These studies characterized serum and intestinal wall eotaxin-1 levels in various inflammatory bowel disease patients and to explore the effect of targeting eotaxin-1 by specific antibodies in dextran sodium sulfate-induced colitis model.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CCL11 recombinant proteinPathways associated with CCL11 recombinant protein
 Reference Product  PubMed Publications
 CCR3 recombinant protein  >340 publications with CCL11 and CCR3
 CXCL10 recombinant protein  >108 publications with CCL11 and CXCL10
 CCL22 recombinant protein  >62 publications with CCL11 and CCL22
 STAT6 recombinant protein  >62 publications with CCL11 and STAT6
 CCR5 recombinant protein  >62 publications with CCL11 and CCR5
 CCR2 recombinant protein  >50 publications with CCL11 and CCR2
 CXCR3 recombinant protein  >26 publications with CCL11 and CXCR3
 DPP4 recombinant protein  >1 publications with CCL11 and DPP4
 Products by Pathway  Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
Diseases associated with CCL11 recombinant proteinOrgans/Tissues associated with CCL11 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >745 publications with CCL11 and Inflammation
 Respiratory Tract Diseases Antibodies  >596 publications with CCL11 and Respiratory Tract Diseases
 Hypersensitivity Antibodies  >583 publications with CCL11 and Hypersensitivity
 Asthma Antibodies  >532 publications with CCL11 and Asthma
 Lung Diseases Antibodies  >488 publications with CCL11 and Lung Diseases
 Respiratory Hypersensitivity Antibodies  >425 publications with CCL11 and Respiratory Hypersensitivity
 Necrosis Antibodies  >203 publications with CCL11 and Necrosis
 Bronchial Hyperreactivity Antibodies  >87 publications with CCL11 and Bronchial Hyperreactivity
 Drug Hypersensitivity Antibodies  >82 publications with CCL11 and Drug Hypersensitivity
 Dermatitis, Atopic Antibodies  >63 publications with CCL11 and Dermatitis, Atopic
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >508 publications with CCL11 and Lung
 Heart Antibodies  >76 publications with CCL11 and Heart
 Intestine Antibodies  >57 publications with CCL11 and Intestine
 Uterus Antibodies  >14 publications with CCL11 and Uterus
 Kidney Antibodies  >10 publications with CCL11 and Kidney
 Pancreas Antibodies  >7 publications with CCL11 and Pancreas
 Stomach Antibodies  >7 publications with CCL11 and Stomach
 Mammary Gland Antibodies  >3 publications with CCL11 and Mammary Gland
 Uncharacterized Tissue Antibodies  >1 publications with CCL11 and Uncharacterized Tissue
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