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EPHA4 recombinant protein :: Ephrin type-A receptor 4 (EPHA4) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS967197 EPHA4 recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $1,320 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,320 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,540 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,540 +1 FREE 8GB USB
1 mg (E-Coli)  /  $2,180 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $2,180 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,640 +3 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,640 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ephrin type-A receptor 4 (EPHA4), Recombinant Protein

 Also Known As   

Recombinant Human Ephrin type-A receptor 4 (EPHA4)

 Product Synonym Names    Ephrin type-A receptor 4; EC=2.7.10.1; EPH-like kinase 8; EK8; hEK8; Tyrosine-protein kinase TYRO1; Tyrosine-protein kinase receptor SEK
 Product Gene Name   

EPHA4 recombinant protein

[Similar Products]
 Product Synonym Gene Name    EPHA4; HEK8; SEK; TYRO1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    20-547
 Sequence    V TGSRVYPANE VTLLDSRSVQ GELGWIASPL EGGWEEVSIM DEKNTPIRTY QVCNVMEPSQ NNWLRTDWIT REGAQRVYIE IKFTLRDCNS LPGVMGTCKE TFNLYYYESD NDKERFIREN QFVKIDTIAA DESFTQVDIG DRIMKLNTEI RDVGPLSKKG FYLAFQDVGA CIALVSVRVF YKKCPLTVRN LAQFPDTITG ADTSSLVEVR GSCVNNSEEK DVPKMYCGAD GEWLVPIGNC LCNAGHEERS GECQACKIGY YKALSTDATC AKCPPHSYSV WEGATSCTCD RGFFRADNDA ASMPCTRPPS APLNLISNVN ETSVNLEWSS PQNTGGRQDI SYNVVCKKCG AGDPSKCRPC GSGVHYTPQQ NGLKTTKVSI TDLLAHTNYT FEIWAVNGVS KYNPNPDQSV SVTVTTNQAA PSSIALVQAK EVTRYSVALA WLEPDRPNGV ILEYEVKYYE KDQNERSYRI VRTAARNTDI KGLNPLTSYV FHVRARTAAG YGDFSEPLEV TTNTVPSRII GDGANST
 OMIM    602188
 3D Structure    ModBase 3D Structure for P54764
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of EPHA4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for EPHA4 recombinant protein

   This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
NCBI/Uniprot data below describe general gene information for EPHA4. It may not necessarily be applicable to this product.
 NCBI GI #    4758280
 NCBI GeneID    2043
 NCBI Accession #    NP_004429.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004438.3 [Other Products]
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 UniProt Primary Accession #    P54764 [Other Products]
 UniProt Secondary Accession #    Q2M380; A8K2P1; B2R601; B7Z6Q8 [Other Products]
 UniProt Related Accession #    P54764 [Other Products]
 Molecular Weight    104,507 Da
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 NCBI Official Full Name    ephrin type-A receptor 4
 NCBI Official Synonym Full Names    EPH receptor A4
 NCBI Official Symbol    EPHA4 [Similar Products]
 NCBI Official Synonym Symbols   
SEK; HEK8; TYRO1
[Similar Products]
 NCBI Protein Information    ephrin type-A receptor 4; EK8; EPH-like kinase 8; TYRO1 protein tyrosine kinase; tyrosine-protein kinase TYRO1; tyrosine-protein kinase receptor SEK; receptor protein-tyrosine kinase HEK8
 UniProt Protein Name    Ephrin type-A receptor 4
 UniProt Synonym Protein Names   
EPH-like kinase 8; EK8; hEK8; Tyrosine-protein kinase TYRO1; Tyrosine-protein kinase receptor SEK
 Protein Family    Ephrin type-A receptor
 UniProt Gene Name    EPHA4 [Similar Products]
 UniProt Synonym Gene Names    HEK8; SEK; TYRO1; EK8; hEK8 [Similar Products]
 UniProt Entry Name    EPHA4_HUMAN
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 NCBI Summary for EPHA4    This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]
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 UniProt Comments for EPHA4    EphA4: a tyrosine kinase receptor of the Eph family. Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in hindbrain pattern formation. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels.

Protein type: Protein kinase, TK; Kinase, protein; Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; Eph family

Chromosomal Location of Human Ortholog: 2q36.1

Cellular Component: Golgi apparatus; cell surface; endoplasmic reticulum; integral to plasma membrane; dendrite; postsynaptic density; dendritic spine; perikaryon; postsynaptic membrane; mitochondrial outer membrane; early endosome membrane; axon; cytoplasm; plasma membrane; nerve terminal; cell junction; neuromuscular junction; filopodium

Molecular Function: identical protein binding; protein binding; ephrin receptor binding; transmembrane-ephrin receptor activity; GPI-linked ephrin receptor activity; PH domain binding; ATP binding; protein kinase activity

Biological Process: axon guidance; positive regulation of JNK activity; peptidyl-tyrosine phosphorylation; negative regulation of axon regeneration; protein amino acid autophosphorylation; motor axon guidance; regulation of astrocyte differentiation; positive regulation of dendrite morphogenesis; glial cell migration; regulation of axonogenesis; adult walking behavior; ephrin receptor signaling pathway; cell adhesion; corticospinal tract morphogenesis
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 Research Articles on EPHA4    1. Data indicate that ephrin-A5 binding directly facilitates the formation of Eph/ephrin clusters by inducing conformational changes in the ligand-binding domain (LBD) of EphA4.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with EPHA4 recombinant proteinPathways associated with EPHA4 recombinant protein
 Reference Product  PubMed Publications
 EFNB3 recombinant protein  >26 publications with EPHA4 and EFNB3
 FGFR1 recombinant protein  >5 publications with EPHA4 and FGFR1
 FYN recombinant protein  >5 publications with EPHA4 and FYN
 EFNB2 recombinant protein  >3 publications with EPHA4 and EFNB2
 NGEF recombinant protein  >3 publications with EPHA4 and NGEF
 FGFR3 recombinant protein  >2 publications with EPHA4 and FGFR3
 EFNA3 recombinant protein  >2 publications with EPHA4 and EFNA3
 FGFR4 recombinant protein  >1 publications with EPHA4 and FGFR4
 FGFR2 recombinant protein  >1 publications with EPHA4 and FGFR2
 EFNA5 recombinant protein  >1 publications with EPHA4 and EFNA5
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 EPHA Forward Signaling Pathway antibodies  EPHA Forward Signaling Pathway Diagram
 EphrinA-EPHA Pathway antibodies  EphrinA-EPHA Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
Diseases associated with EPHA4 recombinant proteinOrgans/Tissues associated with EPHA4 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >27 publications with EPHA4 and Neoplasms
 Inflammation Antibodies  >8 publications with EPHA4 and Inflammation
 Immune System Diseases Antibodies  >6 publications with EPHA4 and Immune System Diseases
 Prostatic Diseases Antibodies  >4 publications with EPHA4 and Prostatic Diseases
 Prostatic Neoplasms Antibodies  >4 publications with EPHA4 and Prostatic Neoplasms
 Necrosis Antibodies  >4 publications with EPHA4 and Necrosis
 Breast Neoplasms Antibodies  >3 publications with EPHA4 and Breast Neoplasms
 Heart Diseases Antibodies  >2 publications with EPHA4 and Heart Diseases
 Atherosclerosis Antibodies  >2 publications with EPHA4 and Atherosclerosis
 Thrombosis Antibodies  >2 publications with EPHA4 and Thrombosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >166 publications with EPHA4 and Brain
 Embryonic Tissue Antibodies  >56 publications with EPHA4 and Embryonic Tissue
 Muscle Antibodies  >32 publications with EPHA4 and Muscle
 Blood Antibodies  >26 publications with EPHA4 and Blood
 Eye Antibodies  >25 publications with EPHA4 and Eye
 Bone Antibodies  >22 publications with EPHA4 and Bone
 Vascular Antibodies  >17 publications with EPHA4 and Vascular
 Skin Antibodies  >9 publications with EPHA4 and Skin
 Kidney Antibodies  >9 publications with EPHA4 and Kidney
 Connective Tissue Antibodies  >6 publications with EPHA4 and Connective Tissue
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