NP_004435.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,195 Da
NCBI Official Full Name
ephrin type-B receptor 4
NCBI Official Synonym Full Names
EPH receptor B4
NCBI Protein Information
ephrin type-B receptor 4
UniProt Protein Name
Ephrin type-B receptor 4
UniProt Synonym Protein Names
Hepatoma transmembrane kinase; Tyrosine-protein kinase TYRO11
UniProt Synonym Gene Names
NCBI Summary for EPHB4
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]
UniProt Comments for EPHB4
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.
Research Articles on EPHB4
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Products associated with EPHB4 recombinant protein
Pathways associated with EPHB4 recombinant protein
Diseases associated with EPHB4 recombinant protein
Organs/Tissues associated with EPHB4 recombinant protein
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