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EPGN recombinant protein :: Epigen Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS539460 EPGN recombinant protein
Unit / Price
0.025 mg  /  $310 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Epigen (EPGN), Recombinant Protein

 Also Known As   

Epigen protein

 Product Synonym Names    EPG protein; Epithelial mitogen protein
 Product Gene Name   

EPGN recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q6UW88
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 Host    Human
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 Purity/Purification    > 98% pure
 Form/Format    Supplied as a lyophilized powder.
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 Protein Type    Recombinant
 Biological Significance    Epigen is an EGF-related polypeptide growth factor that signals through the ErbB receptor-1. It is produced in several tissues, including the testis, liver, heart and in certain tumor cells. Epigen is mitogenic for fibroblasts and epithelial cells. Human Epigen is initially synthesized as a glycosylated 14.7 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a mature soluble sequence. Recombinant human Epigen is a 7.9 kDa monomeric protein, containing 72 amino acid residues, which comprises the EGF homologous portion of the Epigen precursor.
 Bioactivity    Determined by the dose-dependent stimulation of the proliferation of Mouse Balb/3T3 cells. The expected ED50 for this effect is 150-300 ng/ml.
 Endotoxin Levels    Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
 Expression System    E Coli
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 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of EPGN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for EPGN recombinant protein

   Purified recombinant Human Epigen protein
 Product Categories/Family for EPGN recombinant protein    Cytokines & Growth Factors
 Applications Tested/Suitable for EPGN recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for EPGN. It may not necessarily be applicable to this product.
 NCBI GI #    61806622
 NCBI GeneID    255324
 NCBI Accession #    NP_001013460.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001013442.1 [Other Products]
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 UniProt Primary Accession #    Q6UW88 [Other Products]
 UniProt Secondary Accession #    A1BMM3; A1BMM4; A1BMM5; A1BMM6; A1BMM7; A1BMM8; A8K090 [Other Products]
 UniProt Related Accession #    Q6UW88 [Other Products]
 Molecular Weight    7.9 kDa [Similar Products]
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 NCBI Official Synonym Full Names    epithelial mitogen
 NCBI Official Symbol    EPGN [Similar Products]
 NCBI Official Synonym Symbols   
EPG; PRO9904; ALGV3072
[Similar Products]
 NCBI Protein Information    epigen
 UniProt Protein Name    Epigen
 UniProt Synonym Protein Names   
Epithelial mitogen; EPG
 Protein Family    Epigen
 UniProt Gene Name    EPGN [Similar Products]
 UniProt Synonym Gene Names    EPG [Similar Products]
 UniProt Entry Name    EPGN_HUMAN
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 NCBI Summary for EPGN    The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
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 UniProt Comments for EPGN    Epigen: Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Ligand, receptor tyrosine kinase

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular space; integral to plasma membrane

Molecular Function: growth factor activity; epidermal growth factor receptor binding

Biological Process: positive regulation of MAP kinase activity; positive regulation of mitosis; positive regulation of epidermal growth factor receptor activity; activation of MAPK activity; positive regulation of cell proliferation; MAPKKK cascade; angiogenesis; positive regulation of epithelial cell proliferation
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 Research Articles on EPGN    1. cloning of a related gene in mouse
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with EPGN recombinant proteinDiseases associated with EPGN recombinant protein
 Reference Product  PubMed Publications
 AREG recombinant protein  >11 publications with EPGN and AREG
 BTC recombinant protein  >7 publications with EPGN and BTC
 HBEGF recombinant protein  >5 publications with EPGN and HBEGF
 NRG4 recombinant protein  >2 publications with EPGN and NRG4
 Disease Name  Pubmed Publications
 Hyperplasia Antibodies  >3 publications with EPGN and Hyperplasia
 Breast Neoplasms Antibodies  >2 publications with EPGN and Breast Neoplasms
 Atrophy Antibodies  >2 publications with EPGN and Atrophy
 Bone Diseases Antibodies  >2 publications with EPGN and Bone Diseases
 Necrosis Antibodies  >2 publications with EPGN and Necrosis
 Kidney Diseases Antibodies  >1 publications with EPGN and Kidney Diseases
 Nephritis Antibodies  >1 publications with EPGN and Nephritis
 Neoplasms, Experimental Antibodies  >1 publications with EPGN and Neoplasms, Experimental
 Inflammation Antibodies  >1 publications with EPGN and Inflammation
 Prostatic Diseases Antibodies  >1 publications with EPGN and Prostatic Diseases
Organs/Tissues associated with EPGN recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with EPGN and Lung
 Brain Antibodies  >1 publications with EPGN and Brain
 Uterus Antibodies  >1 publications with EPGN and Uterus
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