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EREG recombinant protein :: Epiregulin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143299 EREG recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Epiregulin (EREG), Recombinant Protein

 Also Known As   

Recombinant Human Epiregulin

 Product Synonym Names    EREG Human; Epiregulin Human Recombinant; EREG; Epiregulin; ER
 Product Gene Name   

EREG recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MVAQVSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFFL .
 OMIM    602061
 3D Structure    ModBase 3D Structure for O14944
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 Host    E Coli
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 Purity/Purification    Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    Epiregulin was lyophilized from 0.5mg/ml solution ciontaing 20mM PBS buffer pH-7.4 containing 130mM sodium chloride.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized Epiregulin in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
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 Preparation and Storage    Lyophilized Epiregulin although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Epiregulin should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of EREG recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for EREG recombinant protein

   Description: Epiregulin Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 50 amino acids and having a molecular mass of 6 kDa. Epiregulin is purified by proprietary chromatographic techniques.

Introduction: Epiregulin is part of the EGF family. Epiregulin functions as a ligand of EGFR, as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors.Epiregulin is expressed mostly in the placenta and peripheral blood leukocytes and in specific carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. Epiregulin inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence.
 Product Categories/Family for EREG recombinant protein    CYTOKINES AND GROWTH FACTORS; Cytokines
NCBI/Uniprot data below describe general gene information for EREG. It may not necessarily be applicable to this product.
 NCBI GI #    4557567
 NCBI GeneID    2069
 NCBI Accession #    NP_001423.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001432.2 [Other Products]
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 UniProt Primary Accession #    O14944 [Other Products]
 UniProt Secondary Accession #    Q6FH69; B2RC66 [Other Products]
 UniProt Related Accession #    O14944 [Other Products]
 Molecular Weight    19,044 Da
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 NCBI Official Full Name    proepiregulin preproprotein
 NCBI Official Synonym Full Names    epiregulin
 NCBI Official Symbol    EREG [Similar Products]
 NCBI Official Synonym Symbols   
ER
[Similar Products]
 NCBI Protein Information    proepiregulin
 UniProt Protein Name    Proepiregulin
 Protein Family    Proepiregulin
 UniProt Gene Name    EREG [Similar Products]
 UniProt Synonym Gene Names    EPR [Similar Products]
 UniProt Entry Name    EREG_HUMAN
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 NCBI Summary for EREG    Epiregulin is a member of the epidermal growth factor family. Epiregulin can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. [provided by RefSeq, Jul 2008]
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 UniProt Comments for EREG    Epiregulin: Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular space; integral to plasma membrane; extracellular region

Molecular Function: protein binding; growth factor activity; epidermal growth factor receptor binding

Biological Process: response to peptide hormone stimulus; wound healing; nerve growth factor receptor signaling pathway; activation of MAPK activity; positive regulation of smooth muscle cell proliferation; positive regulation of interleukin-6 biosynthetic process; female meiosis; negative regulation of smooth muscle cell differentiation; negative regulation of cell proliferation; positive regulation of fibroblast proliferation; primary follicle stage, oogenesis; positive regulation of epidermal growth factor receptor activity; cell-cell signaling; positive regulation of innate immune response; positive regulation of cell proliferation; ovarian cumulus expansion; angiogenesis; negative regulation of epithelial cell proliferation; positive regulation of cytokine production; epidermal growth factor receptor signaling pathway; anatomical structure morphogenesis; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of mitosis; cytokine and chemokine mediated signaling pathway; positive regulation of cytokine biosynthetic process; keratinocyte proliferation; luteinizing hormone signaling pathway; oocyte maturation; keratinocyte differentiation; ovulation; organ morphogenesis; positive regulation of protein kinase activity; mRNA transcription; innate immune response; negative regulation of transcription, DNA-dependent; positive regulation of phosphorylation; positive regulation of DNA replication
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 Research Articles on EREG    1. Epiregulin is a transcriptional target of TSC2 (tuberin).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with EREG recombinant proteinPathways associated with EREG recombinant protein
 Reference Product  PubMed Publications
 EGFR recombinant protein  >90 publications with EREG and EGFR
 BTC recombinant protein  >48 publications with EREG and BTC
 HBEGF recombinant protein  >33 publications with EREG and HBEGF
 ERBB2 recombinant protein  >22 publications with EREG and ERBB2
 ERBB4 recombinant protein  >12 publications with EREG and ERBB4
 NRG1 recombinant protein  >8 publications with EREG and NRG1
 ERBB3 recombinant protein  >8 publications with EREG and ERBB3
 NRG2 recombinant protein  >5 publications with EREG and NRG2
 NRG4 recombinant protein  >3 publications with EREG and NRG4
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 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 ErbB Receptor Signaling Network Pathway antibodies  ErbB Receptor Signaling Network Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
Diseases associated with EREG recombinant proteinOrgans/Tissues associated with EREG recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >37 publications with EREG and Carcinoma
 Adenocarcinoma Antibodies  >16 publications with EREG and Adenocarcinoma
 Lung Neoplasms Antibodies  >15 publications with EREG and Lung Neoplasms
 Breast Neoplasms Antibodies  >15 publications with EREG and Breast Neoplasms
 Inflammation Antibodies  >13 publications with EREG and Inflammation
 Lung Diseases Antibodies  >13 publications with EREG and Lung Diseases
 Necrosis Antibodies  >11 publications with EREG and Necrosis
 Cell Transformation, Neoplastic Antibodies  >7 publications with EREG and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >7 publications with EREG and Liver Diseases
 Neoplasms, Experimental Antibodies  >7 publications with EREG and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >24 publications with EREG and Blood
 Lung Antibodies  >22 publications with EREG and Lung
 Skin Antibodies  >16 publications with EREG and Skin
 Liver Antibodies  >13 publications with EREG and Liver
 Muscle Antibodies  >12 publications with EREG and Muscle
 Intestine Antibodies  >7 publications with EREG and Intestine
 Mouth Antibodies  >7 publications with EREG and Mouth
 Kidney Antibodies  >4 publications with EREG and Kidney
 Brain Antibodies  >4 publications with EREG and Brain
 Lymph Node Antibodies  >2 publications with EREG and Lymph Node
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