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EPO recombinant protein :: Erythropoietin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS650641 EPO recombinant protein
Unit / Price
50 Units  /  $235 +1 FREE 8GB USB
100 Units  /  $290 +1 FREE 8GB USB
500 Units  /  $740 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Erythropoietin (EPO), Recombinant Protein

★Popular Item★
 Also Known As   

Erythropoietin, Recombinant, Human (EPO)

 Product Gene Name   

EPO recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 7; NC_000007.13 (100318423..100321323). Location: 7q22
 OMIM    133170
 3D Structure    ModBase 3D Structure for P01588
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 Purity/Purification    > or = 95%
 Form/Format    Supplied as a liquid in PBS, 0.1% BSA
 Concentration    5000 u/ml (lot specific)
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 Source    cDNA obtained from human genes epressed in CHO
 Specific Activity    1.2 x 10e5 u/mg
    
 Assay Used to Measure Bioactivity    Proliferation of reticulocytes in mouse blood is method used for unit measurement and calibrated to the World Health Organization (WHO) standard.
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 Preparation and Storage    Aliquot to avoid repeated freezing and thawing and store at -70 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Shipping: Ships on dry ice.
 Other Notes    Small volumes of EPO recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for EPO recombinant protein

   Erythropoietin, normally produced in the kidney and liver, is the principle hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Indicated for treatment of neutropenia or anemia secondary to ZDV- or Ganciclovir-induced bone marrow suppression (most effective in patients with endogenous EPO levels. <500IU/ml).
 Product Categories/Family for EPO recombinant protein    Growth Factors, Cytokines; Growth Factors-EPO
NCBI/Uniprot data below describe general gene information for EPO. It may not necessarily be applicable to this product.
 NCBI GI #    312304
 NCBI GeneID    2056
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 UniProt Primary Accession #    P01588 [Other Products]
 UniProt Secondary Accession #    Q2M2L6; Q549U2; Q9UDZ0; Q9UEZ5; Q9UHA0 [Other Products]
 UniProt Related Accession #    P01588 [Other Products]
 Molecular Weight    34-36kD [Similar Products]
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 NCBI Official Full Name    erythropoietin
 NCBI Official Synonym Full Names    erythropoietin
 NCBI Official Symbol    EPO [Similar Products]
 NCBI Official Synonym Symbols   
EP; MVCD2; MGC138142
[Similar Products]
 NCBI Protein Information    erythropoietin; epoetin; OTTHUMP00000201234
 UniProt Protein Name    Erythropoietin
 Protein Family    Erythropoietin
 UniProt Entry Name    EPO_HUMAN
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 NCBI Summary for EPO    This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq]
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 UniProt Comments for EPO    EPO: Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Genetic variation in EPO is associated with susceptbility to microvascular complications of diabetes type 2 (MVCD2). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the EPO/TPO family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7q22

Cellular Component: extracellular space; cell surface; extracellular region

Molecular Function: protein binding; erythropoietin receptor binding; hormone activity; protein kinase activator activity

Biological Process: hemoglobin biosynthetic process; erythrocyte maturation; apoptosis; blood circulation; positive regulation of transcription, DNA-dependent; response to lipopolysaccharide; response to testosterone stimulus; signal transduction; response to salt stress; response to vitamin A; peptidyl-serine phosphorylation; response to hyperoxia; positive regulation of tyrosine phosphorylation of Stat5 protein; response to estrogen stimulus; positive regulation of protein kinase activity; positive regulation of cell proliferation; response to axon injury; positive regulation of Ras protein signal transduction; positive regulation of neuron differentiation; response to electrical stimulus; embryo implantation; positive regulation of DNA replication; aging

Disease: Microvascular Complications Of Diabetes, Susceptibility To, 2
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 Research Articles on EPO    1. downregulation of sEPOR by intermittent hypoxia modulates the subsequent EPO response
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with EPO recombinant proteinPathways associated with EPO recombinant protein
 Reference Product  PubMed Publications
 EPOR recombinant protein  >566 publications with EPO and EPOR
 HIF1A recombinant protein  >193 publications with EPO and HIF1A
 RB1 recombinant protein  >1 publications with EPO and RB1
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 EPO Receptor Signaling Pathway antibodies  EPO Receptor Signaling Pathway Diagram
 EPO Signaling Pathway antibodies  EPO Signaling Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 HIF-2-alpha Transcription Factor Network Pathway antibodies  HIF-2-alpha Transcription Factor Network Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
Diseases associated with EPO recombinant proteinOrgans/Tissues associated with EPO recombinant protein
 Disease Name  Pubmed Publications
 Anemia Antibodies  >2385 publications with EPO and Anemia
 Kidney Diseases Antibodies  >1183 publications with EPO and Kidney Diseases
 Neoplasms Antibodies  >1061 publications with EPO and Neoplasms
 Renal Insufficiency Antibodies  >882 publications with EPO and Renal Insufficiency
 Kidney Failure, Chronic Antibodies  >844 publications with EPO and Kidney Failure, Chronic
 Leukemia Antibodies  >546 publications with EPO and Leukemia
 Inflammation Antibodies  >426 publications with EPO and Inflammation
 Central Nervous System Diseases Antibodies  >360 publications with EPO and Central Nervous System Diseases
 Heart Diseases Antibodies  >279 publications with EPO and Heart Diseases
 Hypertension Antibodies  >270 publications with EPO and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >586 publications with EPO and Brain
 Eye Antibodies  >106 publications with EPO and Eye
 Prostate Antibodies  >26 publications with EPO and Prostate
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