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ER-a recombinant protein :: Estrogen Receptor Alpha Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143052 ER-a recombinant protein
Unit / Price
0.002 mg  /  $265 +1 FREE 8GB USB
0.005 mg  /  $365 +1 FREE 8GB USB
0.01 mg  /  $610 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Estrogen Receptor Alpha (ER-a), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Estrogen Receptor Alpha

 Product Synonym Names    ERa Human; Estrogen Receptor alpha Human Recombinant; Estrogen receptor; ER; Estradiol receptor; ER-alpha; Nuclear receptor subfamily 3 group A member 1; ESR1; ESR; NR3A1; Era; ESRA; DKFZp686N23123; ER-a; Estrogen Receptor alpha
 Product Gene Name   

ER-a recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    133430
 3D Structure    ModBase 3D Structure for P03372
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 Host    E Coli
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 Form/Format    ER-alpha at 100 ug/ml in 50mM Tris-HCl, pH7.5 and 10mM L-glutathione (reduced).
Sterile Filtered clear solution.
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 Preparation and Storage    Store vial at -20 degree C to -80 degree C. When stored at the recommended temperature, this protein is stable for 12 months.Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of ER-a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for ER-a recombinant protein

   Description: ER-alpha Human Recombinant (a.a. 1-300) expressed in E Coli, shows a 59 kDa SDS-PAGE.The ER-alpha is purified by proprietary chromatographic techniques.

Introduction: Estrogen receptor is a ligand-activated transcription factor composed of several domains essential for hormone binding, DNA binding, and activation of transcription. Estrogen and its receptors are crucial for sexual development and reproductive function, but also play a role in other tissues such as bone. The Estrogen Receptor is a significant regulator of growth and differentiation in the mammary gland. Estrogen receptors are also implicated in pathological processes including breast cancer, endometrial cancer, and osteoporosis. The presence of estrogen receptors in breast tumors indicates an increased probability of response to anti-estrogen therapy (e.g. tamoxifen).The Estrogen Receptor gene is divided into 8 exons having a genomic length of more than 140kbp.The Estrogen Receptor has 6 functionally separate domains, named A - F. Alternative splicing results in a number of transcript variations, which differ in their 5' UTRs and use different promoters. The protein is restricted to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2.
 Product Categories/Family for ER-a recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for ER-a. It may not necessarily be applicable to this product.
 NCBI GI #    62821794
 NCBI GeneID    2099
 NCBI Accession #    NP_000116.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000125.3 [Other Products]
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 UniProt Primary Accession #    P03372 [Other Products]
 UniProt Secondary Accession #    Q13511; Q14276; Q5T5H7; Q6MZQ9; Q9NU51; Q9UDZ7; Q9UIS7 [Other Products]
 UniProt Related Accession #    P03372 [Other Products]
 Molecular Weight    35,547 Da
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 NCBI Official Full Name    estrogen receptor isoform 1
 NCBI Official Synonym Full Names    estrogen receptor 1
 NCBI Official Symbol    ESR1 [Similar Products]
 NCBI Official Synonym Symbols   
ER; ESR; Era; ESRA; ESTRR; NR3A1
[Similar Products]
 NCBI Protein Information    estrogen receptor; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; nuclear receptor subfamily 3 group A member 1
 UniProt Protein Name    Estrogen receptor
 UniProt Synonym Protein Names   
ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1
 UniProt Gene Name    ESR1 [Similar Products]
 UniProt Synonym Gene Names    ESR; NR3A1; ER [Similar Products]
 UniProt Entry Name    ESR1_HUMAN
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 NCBI Summary for ER-a    This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
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 UniProt Comments for ER-a    ER-alpha: a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 6q25.1

Cellular Component: nucleoplasm; Golgi apparatus; membrane; cytoplasm; integral to membrane; plasma membrane; nucleus

Molecular Function: identical protein binding; estrogen receptor activity; zinc ion binding; nitric-oxide synthase regulator activity; beta-catenin binding; estrogen response element binding; transcription factor binding; steroid binding; protein binding; enzyme binding; steroid hormone receptor activity; chromatin binding; transcription factor activity

Biological Process: estrogen receptor signaling pathway; positive regulation of nitric oxide biosynthetic process; signal transduction; uterus development; response to estradiol stimulus; regulation of apoptosis; elevation of cytosolic calcium ion concentration; positive regulation of fibroblast proliferation; regulation of transcription, DNA-dependent; epithelial cell development; steroid hormone receptor signaling pathway; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; positive regulation of nitric-oxide synthase activity; negative regulation of transcription factor activity; antral ovarian follicle growth; androgen metabolic process; male gonad development; vagina development; positive regulation of retinoic acid receptor signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; chromatin remodeling; response to estrogen stimulus; steroid hormone mediated signaling; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; gene expression

Disease: Migraine With Or Without Aura, Susceptibility To, 1; Breast Cancer; Myocardial Infarction, Susceptibility To; Estrogen Resistance
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 Research Articles on ER-a    1. In breast cancer cells, GSTP1 inhibits the expression of RIP140, a negative regulator of estrogen receptor alpha transcription, at both mRNA and protein levels.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ER-a recombinant proteinPathways associated with ER-a recombinant protein
 Reference Product  PubMed Publications
 BRCA1 recombinant protein  >34 publications with ER-a and BRCA1
 CCND1 recombinant protein  >30 publications with ER-a and CCND1
 SP1 recombinant protein  >17 publications with ER-a and SP1
 SRC recombinant protein  >12 publications with ER-a and SRC
 HDAC1 recombinant protein  >6 publications with ER-a and HDAC1
 NRIP1 recombinant protein  >4 publications with ER-a and NRIP1
 NCOA3 recombinant protein  >4 publications with ER-a and NCOA3
 EP300 recombinant protein  >3 publications with ER-a and EP300
 NCOA1 recombinant protein  >3 publications with ER-a and NCOA1
 NCOA2 recombinant protein  >2 publications with ER-a and NCOA2
 Products by Pathway  Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 FOXM1 Transcription Factor Network Pathway antibodies  FOXM1 Transcription Factor Network Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
Diseases associated with ER-a recombinant proteinOrgans/Tissues associated with ER-a recombinant protein
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >294 publications with ER-a and Breast Neoplasms
 Carcinoma Antibodies  >119 publications with ER-a and Carcinoma
 Female Urogenital Diseases Antibodies  >116 publications with ER-a and Female Urogenital Diseases
 Adenocarcinoma Antibodies  >61 publications with ER-a and Adenocarcinoma
 Disease Progression Antibodies  >52 publications with ER-a and Disease Progression
 Bone Diseases, Metabolic Antibodies  >45 publications with ER-a and Bone Diseases, Metabolic
 Obesity Antibodies  >36 publications with ER-a and Obesity
 Neoplasm Metastasis Antibodies  >28 publications with ER-a and Neoplasm Metastasis
 Prostatic Neoplasms Antibodies  >27 publications with ER-a and Prostatic Neoplasms
 Infertility, Female Antibodies  >27 publications with ER-a and Infertility, Female
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >108 publications with ER-a and Brain
 Ovary Antibodies  >72 publications with ER-a and Ovary
 Uterus Antibodies  >70 publications with ER-a and Uterus
 Testis Antibodies  >61 publications with ER-a and Testis
 Heart Antibodies  >45 publications with ER-a and Heart
 Prostate Antibodies  >42 publications with ER-a and Prostate
 Muscle Antibodies  >35 publications with ER-a and Muscle
 Connective Tissue Antibodies  >31 publications with ER-a and Connective Tissue
 Lung Antibodies  >29 publications with ER-a and Lung
 Mammary Gland Antibodies  >26 publications with ER-a and Mammary Gland
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