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SULT1E1 recombinant protein :: Estrogen Sulfotransferase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143649 SULT1E1 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Estrogen Sulfotransferase (SULT1E1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Estrogen Sulfotransferase

 Product Synonym Names    SULT1E1 Human; Estrogen Sulfotransferase Human Recombinant; EST; STE; EST-1; MGC34459; SULT1E1; Estrogen sulfotransferase; Sulfotransferase estrogen-preferring
 Product Gene Name   

SULT1E1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MNSELDYYEK FEEVHGILMY KDFVKYWDNV EAFQARPDDL VIATYPKSGT TWVSEIVYMI YKEGDVEKCK EDVIFNRIPF LECRKENLMN GVKQLDEMNS PRIVKTHLPP ELLPASFWEK DCKIIYLCRN AKDVAVSFYY FFLMVAGHPN PGSLPEFVEK FMQGQVPYGS WYKHVKSWWE KGKSPRVLFL FYEDLKEDIR KEVIKLIHFL ERKPSEELVD RIIHHTSFQE MKNNPSTNYT TLPDEIMNQK LSPFMRKGIT GDWKNHFTVA LNEKFDKHYE QQMKESTLKF RTEILEHHHH HH
 OMIM    600043
 3D Structure    ModBase 3D Structure for P49888
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    The SULT1E1 protein solution contains 20mM Tris-HCl, pH-8 and 20% Glycerol.
Sterile filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of SULT1E1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SULT1E1 recombinant protein

   Description: Recombinant Human SULT1E1 produced in E Coli is a single, non-glycosylated polypeptide chain containing 302 amino acids (1-294 a.a.) and having a molecular mass of 36.1 kDa. SULT1E1 is fused to 6 amino acid His Tag at C-terminus and purified by conventional chromatography techniques.

Introduction: SULT1E1 catalyzes the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. SULTIE1 control the level of the estrogen receptor by sulfurylating free estradiol. maximally sulfates beta-estradiol and estrone at concentrations of 20nm. SULTIE1 in addition sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at considerably higher concentrations; though, cortisol, testosterone and dopamine are not sulfated. Decreased SULT1E1 expression is linked with estrogen-dependent endometrial carcinomas. Altered cellular proliferation was detected in cells stably expressing SULT1E1.
 Product Categories/Family for SULT1E1 recombinant protein    ENZYMES; Enzymes; Transferase
NCBI/Uniprot data below describe general gene information for SULT1E1. It may not necessarily be applicable to this product.
 NCBI GI #    4885617
 NCBI GeneID    6783
 NCBI Accession #    NP_005411.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005420.2 [Other Products]
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 UniProt Primary Accession #    P49888 [Other Products]
 UniProt Secondary Accession #    Q8N6X5 [Other Products]
 UniProt Related Accession #    P49888 [Other Products]
 Molecular Weight    35,126 Da
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 NCBI Official Full Name    estrogen sulfotransferase
 NCBI Official Synonym Full Names    sulfotransferase family 1E, estrogen-preferring, member 1
 NCBI Official Symbol    SULT1E1 [Similar Products]
 NCBI Official Synonym Symbols   
EST; STE; EST-1; ST1E1
[Similar Products]
 NCBI Protein Information    estrogen sulfotransferase; estrone sulfotransferase; sulfotransferase 1E1; sulfotransferase, estrogen-preferring
 UniProt Protein Name    Estrogen sulfotransferase
 UniProt Synonym Protein Names   
EST-1; Sulfotransferase 1E1; ST1E1; Sulfotransferase, estrogen-preferring
 Protein Family    Estrogen sulfotransferase
 UniProt Gene Name    SULT1E1 [Similar Products]
 UniProt Synonym Gene Names    STE; ST1E1 [Similar Products]
 UniProt Entry Name    ST1E1_HUMAN
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 NCBI Summary for SULT1E1    Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SULT1E1    SULT1E1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated. Belongs to the sulfotransferase 1 family.

Protein type: Transferase; EC 2.8.2.4; Lipid Metabolism - androgen and estrogen; Energy Metabolism - sulfur

Chromosomal Location of Human Ortholog: 4q13.1

Cellular Component: cytosol

Molecular Function: steroid sulfotransferase activity; estrone sulfotransferase activity; flavonol 3-sulfotransferase activity; steroid binding

Biological Process: steroid metabolic process; estrogen metabolic process; xenobiotic metabolic process; sulfation; female pregnancy; 3'-phosphoadenosine 5'-phosphosulfate metabolic process
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 Research Articles on SULT1E1    1. Authors propose that the formation of this DNA loop and protein-bound complex prevents additional binding of ETS1 and p53 R273H proteins to other proximal binding sites.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SULT1E1 recombinant proteinPathways associated with SULT1E1 recombinant protein
 Reference Product  PubMed Publications
 CYP1A1 recombinant protein  >10 publications with SULT1E1 and CYP1A1
 UGT1A1 recombinant protein  >7 publications with SULT1E1 and UGT1A1
 UGT1A9 recombinant protein  >5 publications with SULT1E1 and UGT1A9
 CYP3A4 recombinant protein  >5 publications with SULT1E1 and CYP3A4
 CYP3A5 recombinant protein  >4 publications with SULT1E1 and CYP3A5
 PAPSS2 recombinant protein  >4 publications with SULT1E1 and PAPSS2
 UGT1A3 recombinant protein  >2 publications with SULT1E1 and UGT1A3
 UGT1A5 recombinant protein  >2 publications with SULT1E1 and UGT1A5
 UGT1A6 recombinant protein  >1 publications with SULT1E1 and UGT1A6
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cytosolic Sulfonation Of Small Molecules Pathway antibodies  Cytosolic Sulfonation Of Small Molecules Pathway Diagram
 Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway antibodies  Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway Diagram
 Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway antibodies  Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway Diagram
 Defective GGT1 Causes Glutathionuria (GLUTH) Pathway antibodies  Defective GGT1 Causes Glutathionuria (GLUTH) Pathway Diagram
 Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway antibodies  Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway Diagram
 Defective MAT1A Causes Methionine Adenosyltransferase Deficiency (MATD) Pathway antibodies  Defective MAT1A Causes Methionine Adenosyltransferase Deficiency (MATD) Pathway Diagram
 Defective OPLAH Causes 5-oxoprolinase Deficiency (OPLAHD) Pathway antibodies  Defective OPLAH Causes 5-oxoprolinase Deficiency (OPLAHD) Pathway Diagram
 Defective SLC35D1 Causes Schneckenbecken Dysplasia (SCHBCKD) Pathway antibodies  Defective SLC35D1 Causes Schneckenbecken Dysplasia (SCHBCKD) Pathway Diagram
 Defective TPMT Causes Thiopurine S-methyltransferase Deficiency (TPMT Deficiency) Pathway antibodies  Defective TPMT Causes Thiopurine S-methyltransferase Deficiency (TPMT Deficiency) Pathway Diagram
Diseases associated with SULT1E1 recombinant proteinOrgans/Tissues associated with SULT1E1 recombinant protein
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >15 publications with SULT1E1 and Breast Neoplasms
 Liver Diseases Antibodies  >10 publications with SULT1E1 and Liver Diseases
 Carcinoma Antibodies  >9 publications with SULT1E1 and Carcinoma
 Uterine Neoplasms Antibodies  >9 publications with SULT1E1 and Uterine Neoplasms
 Adenocarcinoma Antibodies  >6 publications with SULT1E1 and Adenocarcinoma
 Liver Neoplasms Antibodies  >5 publications with SULT1E1 and Liver Neoplasms
 Fibrosis Antibodies  >4 publications with SULT1E1 and Fibrosis
 Carcinoma, Hepatocellular Antibodies  >3 publications with SULT1E1 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >3 publications with SULT1E1 and Inflammation
 Neoplasms, Experimental Antibodies  >3 publications with SULT1E1 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >58 publications with SULT1E1 and Liver
 Placenta Antibodies  >8 publications with SULT1E1 and Placenta
 Brain Antibodies  >7 publications with SULT1E1 and Brain
 Kidney Antibodies  >4 publications with SULT1E1 and Kidney
 Embryonic Tissue Antibodies  >3 publications with SULT1E1 and Embryonic Tissue
 Lung Antibodies  >3 publications with SULT1E1 and Lung
 Vascular Antibodies  >2 publications with SULT1E1 and Vascular
 Stomach Antibodies  >2 publications with SULT1E1 and Stomach
 Adrenal Gland Antibodies  >2 publications with SULT1E1 and Adrenal Gland
 Muscle Antibodies  >1 publications with SULT1E1 and Muscle
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