NP_001004283.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
63,989 Da
NCBI Official Full Name
eukaryotic translation initiation factor 3 subunit D
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 3, subunit D
NCBI Official Synonym Symbols
NCBI Protein Information
eukaryotic translation initiation factor 3 subunit D
UniProt Protein Name
Eukaryotic translation initiation factor 3 subunit D
UniProt Synonym Protein Names
Eukaryotic translation initiation factor 3 subunit 7
UniProt Synonym Gene Names
UniProt Comments for Eif3d
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.
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Products associated with Eif3d recombinant protein
Pathways associated with Eif3d recombinant protein
Diseases associated with Eif3d recombinant protein
Organs/Tissues associated with Eif3d recombinant protein
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