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CASR recombinant protein :: Extracellular calcium-sensing receptor (CASR), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS950111 CASR recombinant protein
Unit / Price
1 mg (E-Coli)  /  $1,375 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,835 +2 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Extracellular calcium-sensing receptor (CASR), partial, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Bovine Extracellular calcium-sensing receptor (CASR), partial

 Product Synonym Names    Recombinant Extracellular calcium-sensing receptor (CASR), partial; Extracellular calcium-sensing receptor; CaSR; Parathyroid cell calcium-sensing receptor; PCaR1
 Product Gene Name   

CASR recombinant protein

[Similar Products]
 Product Synonym Gene Name    CASR; GPRC2A, PCAR1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; AC_000158.1 (67255527..67344655). Location: chromosome: 1
 3D Structure    ModBase 3D Structure for P35384
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Bos taurus (Bovine)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CASR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for CASR. It may not necessarily be applicable to this product.
 NCBI GI #    27806719
 NCBI GeneID    281038
 NCBI Accession #    NP_776427.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_174002.2 [Other Products]
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 UniProt Primary Accession #    P35384 [Other Products]
 UniProt Related Accession #    P35384 [Other Products]
 Molecular Weight    121,171 Da [Similar Products]
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 NCBI Official Full Name    extracellular calcium-sensing receptor
 NCBI Official Symbol    CASR [Similar Products]
 NCBI Protein Information    extracellular calcium-sensing receptor; PCaR1; parathyroid Cell calcium-sensing receptor; calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism)
 UniProt Protein Name    Extracellular calcium-sensing receptor
 UniProt Synonym Protein Names   
Parathyroid cell calcium-sensing receptor
 Protein Family    Extracellular calcium-sensing receptor
 UniProt Gene Name    CASR [Similar Products]
 UniProt Synonym Gene Names    GPRC2A; PCAR1; CaSR; PCaR1 [Similar Products]
 UniProt Entry Name    CASR_BOVIN
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 UniProt Comments for CASR    Function: Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.

Subunit structure: Interacts with VCP and RNF19A. Interacts with ARRB1

By similarity.

Subcellular location: Cell membrane; Multi-pass membrane protein.

Post-translational modification: N-glycosylated

By similarity.Ubiquitinated by RNF19A; which induces proteasomal degradation

By similarity.

Sequence similarities: Belongs to the G-protein coupled receptor 3 family.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with CASR recombinant proteinDiseases associated with CASR recombinant protein
 Products by Pathway  Pathway Diagram
 Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway antibodies  Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 Disease Name  Pubmed Publications
 Hyperparathyroidism Antibodies  >172 publications with CASR and Hyperparathyroidism
 Calcium Metabolism Disorders Antibodies  >169 publications with CASR and Calcium Metabolism Disorders
 Hypercalcemia Antibodies  >149 publications with CASR and Hypercalcemia
 Water-Electrolyte Imbalance Antibodies  >125 publications with CASR and Water-Electrolyte Imbalance
 Hypocalcemia Antibodies  >90 publications with CASR and Hypocalcemia
 Neoplasms Antibodies  >83 publications with CASR and Neoplasms
 Kidney Diseases Antibodies  >74 publications with CASR and Kidney Diseases
 Hyperparathyroidism, Secondary Antibodies  >56 publications with CASR and Hyperparathyroidism, Secondary
 Hypoparathyroidism Antibodies  >55 publications with CASR and Hypoparathyroidism
 Hypertension Antibodies  >22 publications with CASR and Hypertension
Organs/Tissues associated with CASR recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >176 publications with CASR and Kidney
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