NP_001296567.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
120,868 Da
NCBI Official Full Name
extracellular calcium-sensing receptor
NCBI Official Synonym Full Names
calcium-sensing receptor
NCBI Protein Information
extracellular calcium-sensing receptor
UniProt Protein Name
Extracellular calcium-sensing receptor
UniProt Synonym Protein Names
Parathyroid cell calcium-sensing receptor; PCaR1; RaKCaR
UniProt Synonym Gene Names
NCBI Summary for Casr
a G protein-coupled receptor that senses extracellular calcium; involved in regulating the secretion of parathyroid hormone, bile and intestinal fluid [RGD, Feb 2006]
UniProt Comments for Casr
G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7816802). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation ().
Research Articles on Casr
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Products associated with Casr recombinant protein
Pathways associated with Casr recombinant protein
Diseases associated with Casr recombinant protein
Organs/Tissues associated with Casr recombinant protein
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