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DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

Casr recombinant protein :: Extracellular calcium-sensing receptor (Casr) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS967994 Casr recombinant protein
Unit / Price
1 mg (E-Coli)  /  $1,375 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,835 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Extracellular calcium-sensing receptor (Casr), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Rat Extracellular calcium-sensing receptor (Casr) , partial

 Product Gene Name   

Casr recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P48442
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rattus norvegicus (Rat)
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Casr recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Casr. It may not necessarily be applicable to this product.
 NCBI GI #    831181948
 NCBI GeneID    24247
 NCBI Accession #    NP_001296567.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001309638.1 [Other Products]
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 UniProt Primary Accession #    P48442 [Other Products]
 UniProt Related Accession #    P48442 [Other Products]
 Molecular Weight    120,868 Da
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 NCBI Official Full Name    extracellular calcium-sensing receptor
 NCBI Official Synonym Full Names    calcium-sensing receptor
 NCBI Official Symbol    Casr [Similar Products]
 NCBI Official Synonym Symbols   
PCaR1; RaKCaR
[Similar Products]
 NCBI Protein Information    extracellular calcium-sensing receptor
 UniProt Protein Name    Extracellular calcium-sensing receptor
 UniProt Synonym Protein Names   
Parathyroid cell calcium-sensing receptor; PCaR1; RaKCaR
 Protein Family    Extracellular calcium-sensing receptor
 UniProt Gene Name    Casr [Similar Products]
 UniProt Synonym Gene Names    Gprc2a; Pcar1; CaSR; PCaR1; RaKCaR [Similar Products]
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 NCBI Summary for Casr    a G protein-coupled receptor that senses extracellular calcium; involved in regulating the secretion of parathyroid hormone, bile and intestinal fluid [RGD, Feb 2006]
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 UniProt Comments for Casr    G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7816802). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation ().
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 Research Articles on Casr    1. these results suggest that high glucose induces myocardial energy metabolism disorder via decrease of CaSR expression, and activation of gp78-ubiquitin proteasome system.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Casr recombinant proteinPathways associated with Casr recombinant protein
 Reference Product  PubMed Publications
 App recombinant protein  >2 publications with Casr and App
 Adcy5 recombinant protein  >1 publications with Casr and Adcy5
 Npsr1 recombinant protein  >1 publications with Casr and Npsr1
 Products by Pathway  Pathway Diagram
 Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway antibodies  Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway antibodies  GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
Diseases associated with Casr recombinant proteinOrgans/Tissues associated with Casr recombinant protein
 Disease Name  Pubmed Publications
 Hyperparathyroidism Antibodies  >257 publications with Casr and Hyperparathyroidism
 Hypercalcemia Antibodies  >220 publications with Casr and Hypercalcemia
 Hypocalcemia Antibodies  >135 publications with Casr and Hypocalcemia
 Kidney Diseases Antibodies  >107 publications with Casr and Kidney Diseases
 Hypoparathyroidism Antibodies  >86 publications with Casr and Hypoparathyroidism
 Hypertension Antibodies  >49 publications with Casr and Hypertension
 Cardiovascular Diseases Antibodies  >49 publications with Casr and Cardiovascular Diseases
 Inflammation Antibodies  >33 publications with Casr and Inflammation
 Hypocalciuric hypercalcemia, familial, type 1 Antibodies  >33 publications with Casr and Hypocalciuric hypercalcemia, familial, type 1
 Brain Diseases Antibodies  >27 publications with Casr and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >263 publications with Casr and Kidney
 Brain Antibodies  >55 publications with Casr and Brain
 Dorsal Root Ganglion Antibodies  >3 publications with Casr and Dorsal Root Ganglion
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