NP_001104547.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
69,413 Da
NCBI Official Full Name
ezrin
NCBI Official Synonym Full Names
ezrin
NCBI Protein Information
ezrin
UniProt Protein Name
Ezrin
UniProt Synonym Protein Names
Cytovillin; Villin-2; p81
UniProt Synonym Gene Names
NCBI Summary for EZR
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for EZR
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
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Products associated with EZR recombinant protein
Pathways associated with EZR recombinant protein
Diseases associated with EZR recombinant protein
Organs/Tissues associated with EZR recombinant protein
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