NP_000498.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39.0 kDa (358aa), confirmed by MALDI-TOF.
NCBI Official Full Name
fructose-1,6-bisphosphatase 1
NCBI Official Synonym Full Names
fructose-bisphosphatase 1
NCBI Official Synonym Symbols
NCBI Protein Information
fructose-1,6-bisphosphatase 1
UniProt Protein Name
Fructose-1,6-bisphosphatase 1
UniProt Synonym Protein Names
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; Liver FBPase
UniProt Synonym Gene Names
NCBI Summary for FBP1
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]
UniProt Comments for FBP1
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
Product References and Citations for FBP1 recombinant protein
Rabenhorst u., et al. (2009) Hepatology. 50 (4):1121-9. ; Hirota K., et al. (2008) Nature. 456 (7218):130-4.;
Research Articles on FBP1
Precautions
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Products associated with FBP1 recombinant protein
Pathways associated with FBP1 recombinant protein
Diseases associated with FBP1 recombinant protein
Organs/Tissues associated with FBP1 recombinant protein
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