NP_005108.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
fibroblast growth factor 19
NCBI Official Synonym Full Names
fibroblast growth factor 19
NCBI Protein Information
fibroblast growth factor 19; FGF-19
UniProt Protein Name
Fibroblast growth factor 19
UniProt Synonym Gene Names
UniProt Entry Name
FGF19_HUMAN
NCBI Summary for FGF19
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008]
UniProt Comments for FGF19
FGF19: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. Belongs to the heparin-binding growth factors family.
Protein type: Secreted; Cell development/differentiation; Motility/polarity/chemotaxis; Secreted, signal peptide; Cytokine
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: extracellular region
Molecular Function: protein binding; growth factor activity; fibroblast growth factor receptor binding
Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of glucose import; nervous system development; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; heart development; positive regulation of cell proliferation; insulin receptor signaling pathway; positive regulation of JNK cascade; innate immune response; positive regulation of protein amino acid phosphorylation; neural crest cell migration
Research Articles on FGF19
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Products associated with FGF19 active protein
Pathways associated with FGF19 active protein
Diseases associated with FGF19 active protein
Organs/Tissues associated with FGF19 active protein
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