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FGF 8 recombinant protein

Scan QR to view Datasheet Catalog #    MBS232308 FGF 8 recombinant protein
Unit / Price
0.025 mg  /  $440 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FGF 8, Recombinant Protein

 Also Known As   

RECOMBINANT HUMAN FGF 8

 Product Gene Name   

FGF 8 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600483
 3D Structure    ModBase 3D Structure for P55075
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 Purity/Purification    >95% by SDS PAGE and HPLC analysis
 Form/Format    Purified recombinant protein - lyophilised
 Concentration    Total protein concentration 0.1mg/ml after reconstitution (lot specific)
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 Reconstitution    Reconstitute with 0.25ml distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution. For extended storage, the addition of 0.1% Bovine Serum Albumin is recommended.
Preparation
 Activity    2 x 106 units/mg
 Target Species    Human
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 Preparation and Storage    Prior to reconstitution store at 4 degree C. Following reconstitution store at -20 degree C. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 3 months from date of reconstitution.
 Other Notes    Small volumes of FGF 8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for FGF 8 recombinant protein

   Recombinant human FGF8 is an E Coli-derived protein corresponding to amino acids 23-215 of human fibroblast growth factor 8. FGF8 is a secreted peptide that promotes cell growth in an autocrine manner. The peptide sequence contains an initiator methionine at the N-terminus and is homologous to the murine, canine and bovine sequences. MBS232308 has an ED50 of
 Applications Tested/Suitable for FGF 8 recombinant protein   

Functional Assays (FN)

 Application Notes for FGF 8 recombinant protein    Functional Assays: Minimum Dilution: 0.1ng/ml; Maximum Dilution: 20ng/ml
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NCBI/Uniprot data below describe general gene information for FGF 8. It may not necessarily be applicable to this product.
 NCBI GI #    5174439
 NCBI GeneID    2253
 NCBI Accession #    NP_006110.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006119.4 [Other Products]
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 UniProt Primary Accession #    P55075 [Other Products]
 UniProt Secondary Accession #    Q14915; Q15766; A1A514 [Other Products]
 UniProt Related Accession #    P55075 [Other Products]
 Molecular Weight    Protein Molecular Weight: 22.4kD (193 amino acid sequence)
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 NCBI Official Full Name    fibroblast growth factor 8 isoform B
 NCBI Official Synonym Full Names    fibroblast growth factor 8 (androgen-induced)
 NCBI Official Symbol    FGF8 [Similar Products]
 NCBI Official Synonym Symbols   
HH6; AIGF; KAL6; FGF-8; HBGF-8
[Similar Products]
 NCBI Protein Information    fibroblast growth factor 8; androgen-induced growth factor; heparin-binding growth factor 8
 UniProt Protein Name    Fibroblast growth factor 8
 UniProt Synonym Protein Names   
Androgen-induced growth factor; AIGF; Heparin-binding growth factor 8; HBGF-8
 UniProt Gene Name    FGF8 [Similar Products]
 UniProt Synonym Gene Names    AIGF; FGF-8; AIGF; HBGF-8 [Similar Products]
 UniProt Entry Name    FGF8_HUMAN
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 NCBI Summary for FGF 8    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FGF 8    FGF8: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Defects in FGF8 are the cause of Kallmann syndrome type 6 (KAL6). Kallmann syndrome is a disorder that associates hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone- synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous. Defects in FGF8 are a cause of idiopathic hypogonadotropic hypogonadism (IHH). IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. Belongs to the heparin-binding growth factors family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Cytokine; Secreted

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: extracellular space; extracellular region; external side of plasma membrane

Molecular Function: growth factor activity; type 2 fibroblast growth factor receptor binding; fibroblast growth factor receptor binding; chemoattractant activity; type 1 fibroblast growth factor receptor binding

Biological Process: gonad development; nerve growth factor receptor signaling pathway; apoptosis; cell proliferation in forebrain; adrenocorticotropin hormone secreting cell differentiation; thyroid stimulating hormone secreting cell differentiation; motor axon guidance; forebrain dorsal/ventral pattern formation; gastrulation; Wnt receptor signaling pathway through beta-catenin; mesodermal cell migration; embryonic hindlimb morphogenesis; response to organic cyclic substance; odontogenesis; BMP signaling pathway; positive chemotaxis; induction of an organ; positive regulation of cell proliferation; male genitalia development; thyroid gland development; pallium development; mesonephros development; negative regulation of neuron apoptosis; heart looping; otic vesicle formation; regulation of odontogenesis of dentine-containing teeth; negative regulation of cardiac muscle development; epidermal growth factor receptor signaling pathway; response to drug; anatomical structure morphogenesis; phosphoinositide-mediated signaling; pharyngeal system development; fibroblast growth factor receptor signaling pathway; positive regulation of mitosis; neural plate morphogenesis; MAPKKK cascade; subpallium development; forebrain morphogenesis; dorsal/ventral axon guidance; positive regulation of organ growth; patterning of blood vessels; forebrain neuron development; ureteric bud branching; midbrain-hindbrain boundary development; insulin receptor signaling pathway; innate immune response; blood vessel remodeling; response to oxidative stress; metanephros development

Disease: Hypogonadotropic Hypogonadism 6 With Or Without Anosmia
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 Research Articles on FGF 8    1. Scube3 may be a critical upstream regulator of fast fiber myogenesis by modulating fgf8 signaling during zebrafish embryogenesis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FGF 8 recombinant proteinPathways associated with FGF 8 recombinant protein
 Reference Product  PubMed Publications
 SHH recombinant protein  >241 publications with FGF 8 and SHH
 FGFR1 recombinant protein  >114 publications with FGF 8 and FGFR1
 FGFR2 recombinant protein  >48 publications with FGF 8 and FGFR2
 EN1 recombinant protein  >47 publications with FGF 8 and EN1
 FGFR3 recombinant protein  >37 publications with FGF 8 and FGFR3
 FGFR4 recombinant protein  >21 publications with FGF 8 and FGFR4
 SPRY1 recombinant protein  >13 publications with FGF 8 and SPRY1
 DUSP6 recombinant protein  >11 publications with FGF 8 and DUSP6
 CNPY1 recombinant protein  >1 publications with FGF 8 and CNPY1
 Products by Pathway  Pathway Diagram
 Activated Point Mutants Of FGFR2 Pathway antibodies  Activated Point Mutants Of FGFR2 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 FGFR Ligand Binding And Activation Pathway antibodies  FGFR Ligand Binding And Activation Pathway Diagram
Diseases associated with FGF 8 recombinant proteinOrgans/Tissues associated with FGF 8 recombinant protein
 Disease Name  Pubmed Publications
 Craniofacial Abnormalities Antibodies  >80 publications with FGF 8 and Craniofacial Abnormalities
 Nervous System Diseases Antibodies  >59 publications with FGF 8 and Nervous System Diseases
 Abnormalities, Multiple Antibodies  >57 publications with FGF 8 and Abnormalities, Multiple
 Genital Diseases, Male Antibodies  >49 publications with FGF 8 and Genital Diseases, Male
 Disease Models, Animal Antibodies  >44 publications with FGF 8 and Disease Models, Animal
 Kallmann Syndrome Antibodies  >41 publications with FGF 8 and Kallmann Syndrome
 Cardiovascular Abnormalities Antibodies  >36 publications with FGF 8 and Cardiovascular Abnormalities
 Heart Defects, Congenital Antibodies  >31 publications with FGF 8 and Heart Defects, Congenital
 Cleft Palate Antibodies  >29 publications with FGF 8 and Cleft Palate
 Heart Diseases Antibodies  >26 publications with FGF 8 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >373 publications with FGF 8 and Embryonic Tissue
 Intestine Antibodies  >5 publications with FGF 8 and Intestine
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