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FGF recombinant protein :: FGF acidic Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS538081 FGF recombinant protein
Unit / Price
0.01 mg  /  $180 +1 FREE 8GB USB
0.05 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FGF acidic, Recombinant Protein

 Also Known As   

FGF acidic protein

 Product Synonym Names    HBGF-1 protein; FGF-1 protein; Fibroblast Growth Factor-acidic protein; ECGF-beta protein
 Product Gene Name   

FGF recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Region of FGF acidic protein correspond ing to amino acids MFNLPPGNYK KPKLLYCSNG GHFLRILPDG TVDGTRDRSD QHIQLQLSAE SVGEVYIKST ETGQYLAMDT DGLLYGSQTP NEECLFLERL EENHYNTYIS KKHAEKNWFV GLKKNGSCKR GPRTHYGQKA ILFLPLPVSS D.
 OMIM    134920
 3D Structure    ModBase 3D Structure for P09038
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 Host    Human
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 Purity/Purification    > 95% pure
 Form/Format    Lyophilized from 5mM Na3PO4, pH 8.0 with 100mM NaCl. Reconstitute in 5mM Na3PO4 to a concentration of
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 Protein Type    Recombinant
 Biological Significance    FGF acidic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF acidic is a non-glycosylated heparin binding growth factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells. FGF acidic has the ability to signal through all the FGF receptors.
 Bioactivity    Assay #1: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is approximately 10 ng/ml, corresponding to a specific activity of approximately 1 x 10^5 units/mg. Assay #2: The ED50 was determined by a cell proliferation assay using balb/c 3T3 cells is approximately 0.5 ng/ml in the presence of 10 ug/ml heparin, corresponding to a specific activity of approximately 2 x 10^6 units/mg.
 Endotoxin Levels    Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
 Expression System    E Coli
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 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of FGF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for FGF recombinant protein

   Purified recombinant Human FGF acidic protein
 Product Categories/Family for FGF recombinant protein    Cytokines & Growth Factors
 Applications Tested/Suitable for FGF recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for FGF. It may not necessarily be applicable to this product.
 NCBI GI #    31362
 NCBI GeneID    2247
 NCBI Accession #    CAA28027.1 [Other Products]
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 UniProt Primary Accession #    P09038 [Other Products]
 UniProt Secondary Accession #    O00527; P78443; Q16443; Q5PY50; Q7KZ11; Q7KZ72; Q9UC54; Q9UCS5; Q9UCS6; A4LBB8 [Other Products]
 UniProt Related Accession #    P09038 [Other Products]
 Molecular Weight    15.8 kDa
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 NCBI Official Full Name    fibroblast growth factor, partial
 NCBI Official Synonym Full Names    fibroblast growth factor 2 (basic)
 NCBI Official Symbol    FGF2 [Similar Products]
 NCBI Official Synonym Symbols   
BFGF; FGFB; FGF-2; HBGF-2
[Similar Products]
 NCBI Protein Information    fibroblast growth factor 2
 UniProt Protein Name    Fibroblast growth factor 2
 UniProt Synonym Protein Names   
Basic fibroblast growth factor; bFGF; Heparin-binding growth factor 2; HBGF-2
 Protein Family    Fibroblast growth factor
 UniProt Gene Name    FGF2 [Similar Products]
 UniProt Synonym Gene Names    FGFB; FGF-2; bFGF; HBGF-2 [Similar Products]
 UniProt Entry Name    FGF2_HUMAN
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 NCBI Summary for FGF    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FGF    FGF2: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue. Belongs to the heparin-binding growth factors family. 4 isoforms of the human protein are produced by alternative initiation.

Protein type: Activator; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q26

Cellular Component: extracellular space; extracellular region; nucleus

Molecular Function: heparin binding; protein binding; ligand-dependent nuclear receptor transcription coactivator activity; growth factor activity; cytokine activity; fibroblast growth factor receptor binding; chemoattractant activity

Biological Process: extracellular matrix organization and biogenesis; nerve growth factor receptor signaling pathway; wound healing; somatic stem cell maintenance; activation of MAPK activity; positive regulation of transcription, DNA-dependent; chemotaxis; signal transduction; hyaluronan catabolic process; growth factor dependent regulation of satellite cell proliferation; positive regulation of MAP kinase activity; positive chemotaxis; positive regulation of cell proliferation; embryonic morphogenesis; positive regulation of cardiac muscle cell proliferation; epidermal growth factor receptor signaling pathway; nervous system development; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of cell fate specification; positive regulation of blood vessel endothelial cell migration; positive regulation of phosphoinositide 3-kinase activity; negative regulation of blood vessel endothelial cell migration; regulation of angiogenesis; positive regulation of angiogenesis; organ morphogenesis; cell migration during sprouting angiogenesis; ureteric bud branching; release of sequestered calcium ion into cytosol; positive regulation of cell division; Ras protein signal transduction; insulin receptor signaling pathway; phosphatidylinositol biosynthetic process; innate immune response; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; inositol phosphate biosynthetic process
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 Research Articles on FGF    1. The nuclear odyssey of FGF-2 is reflected by nuclear dynamics, localization to nuclear bodies such as nucleoli, binding to chromatin and engagement in various protein interactions. [review]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with FGF recombinant proteinDiseases associated with FGF recombinant protein
 Products by Pathway  Pathway Diagram
 Activated Point Mutants Of FGFR2 Pathway antibodies  Activated Point Mutants Of FGFR2 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Constitutive Signaling By Aberrant PI3K In Cancer Pathway antibodies  Constitutive Signaling By Aberrant PI3K In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1004 publications with FGF and Nervous System Diseases
 Necrosis Antibodies  >625 publications with FGF and Necrosis
 Wounds and Injuries Antibodies  >589 publications with FGF and Wounds and Injuries
 Inflammation Antibodies  >450 publications with FGF and Inflammation
 Heart Diseases Antibodies  >423 publications with FGF and Heart Diseases
 Myocardial Ischemia Antibodies  >350 publications with FGF and Myocardial Ischemia
 Disease Progression Antibodies  >344 publications with FGF and Disease Progression
 Lung Diseases Antibodies  >333 publications with FGF and Lung Diseases
 Hyperplasia Antibodies  >260 publications with FGF and Hyperplasia
 Lung Neoplasms Antibodies  >228 publications with FGF and Lung Neoplasms
Organs/Tissues associated with FGF recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >4773 publications with FGF and Vascular
 Brain Antibodies  >2203 publications with FGF and Brain
 Bone Antibodies  >1872 publications with FGF and Bone
 Muscle Antibodies  >1820 publications with FGF and Muscle
 Embryonic Tissue Antibodies  >1277 publications with FGF and Embryonic Tissue
 Eye Antibodies  >1032 publications with FGF and Eye
 Skin Antibodies  >830 publications with FGF and Skin
 Connective Tissue Antibodies  >731 publications with FGF and Connective Tissue
 Bone Marrow Antibodies  >671 publications with FGF and Bone Marrow
 Heart Antibodies  >663 publications with FGF and Heart
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