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FGF6 recombinant protein

Scan QR to view Datasheet Catalog #    MBS539444 FGF6 recombinant protein
Unit / Price
0.025 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FGF6, Recombinant Protein

 Also Known As   

FGF6 protein

 Product Synonym Names    Fibroblast Growth Factor-6 protein; FGF 6; FGF 6 protein; FGF-6; HST-2 protein; HBGF-6 protein; FGF6; FGF-6 protein
 Product Gene Name   

FGF6 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Region of FGF6 protein correspond ing to amino acids MGTRANNTLL DSRGWGTLLS RSRAGLAGEI AGVNWESGYL VGIKRQRRLY CNVGIGFHLQ VLPDGRISGT HEENPYSLLE ISTVERGVVS LFGVRSALFV AMNSKGRLYA TPSFQEECKF RETLLPNNYN AYESDLYQGT YIALSKYGRV KRGSKVSPIM TVTHFLPRI.
 OMIM    134921
 3D Structure    ModBase 3D Structure for P10767
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 Host    Human
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 Purity/Purification    > 95% pure
 Form/Format    Supplied as a lyophilized powder.
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 Protein Type    Recombinant
 Biological Significance    FGF6 is a secreted heparin binding growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF6 is expressed in leukemia cell lines with platelet megakaryocytic differentiation potential. It signals through FGFR 1c, 2c, and 4.
 Bioactivity    The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is approximately 0.5 ng/ml, corresponding to a specific activity of approximately 2 x 10^6 units/mg.
 Endotoxin Levels    Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
 Expression System    E Coli
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 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of FGF6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for FGF6 recombinant protein

   Purified recombinant Human FGF6 protein
 Product Categories/Family for FGF6 recombinant protein    Cytokines & Growth Factors
 Applications Tested/Suitable for FGF6 recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for FGF6. It may not necessarily be applicable to this product.
 NCBI GI #    15147343
 NCBI GeneID    2251
 NCBI Accession #    NP_066276.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_020996.1 [Other Products]
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 UniProt Primary Accession #    P10767 [Other Products]
 UniProt Secondary Accession #    Q0VAE1 [Other Products]
 UniProt Related Accession #    P10767 [Other Products]
 Molecular Weight    18.7 kDa
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 NCBI Official Full Name    fibroblast growth factor 6
 NCBI Official Synonym Full Names    fibroblast growth factor 6
 NCBI Official Symbol    FGF6 [Similar Products]
 NCBI Official Synonym Symbols   
HST2; HBGF-6
[Similar Products]
 NCBI Protein Information    fibroblast growth factor 6
 UniProt Protein Name    Fibroblast growth factor 6
 UniProt Synonym Protein Names   
Heparin secretory-transforming protein 2; HST-2; HSTF-2; Heparin-binding growth factor 6; HBGF-6
 Protein Family    Fibroblast growth factor
 UniProt Gene Name    FGF6 [Similar Products]
 UniProt Synonym Gene Names    HST2; HSTF2; FGF-6; HST-2; HSTF-2; HBGF-6 [Similar Products]
 UniProt Entry Name    FGF6_HUMAN
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 NCBI Summary for FGF6    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FGF6    FGF6: Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration. Belongs to the heparin-binding growth factors family.

Protein type: Oncoprotein; Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: extracellular space; extracellular region; sarcolemma

Molecular Function: growth factor activity; fibroblast growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; signal transduction; myoblast differentiation; cell proliferation; cell-cell signaling; positive regulation of cell division; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response; angiogenesis; cartilage condensation
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 Research Articles on FGF6    1. These data demonstrate that FGF-6 may be considered a regulator of bone metabolism as shown by its activity on both osteoblasts and osteoclasts.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FGF6 recombinant proteinPathways associated with FGF6 recombinant protein
 Reference Product  PubMed Publications
 FGF2 recombinant protein  >18 publications with FGF6 and FGF2
 FGFR4 recombinant protein  >16 publications with FGF6 and FGFR4
 FGF1 recombinant protein  >15 publications with FGF6 and FGF1
 FGFR1 recombinant protein  >12 publications with FGF6 and FGFR1
 FGF7 recombinant protein  >11 publications with FGF6 and FGF7
 FGFR2 recombinant protein  >9 publications with FGF6 and FGFR2
 FGFR3 recombinant protein  >6 publications with FGF6 and FGFR3
 FGF23 recombinant protein  >5 publications with FGF6 and FGF23
 FGF19 recombinant protein  >3 publications with FGF6 and FGF19
 FGF18 recombinant protein  >3 publications with FGF6 and FGF18
 Products by Pathway  Pathway Diagram
 Activated Point Mutants Of FGFR2 Pathway antibodies  Activated Point Mutants Of FGFR2 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive Signaling By Aberrant PI3K In Cancer Pathway antibodies  Constitutive Signaling By Aberrant PI3K In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signaling Of Activated FGFR1 Pathway antibodies  Downstream Signaling Of Activated FGFR1 Pathway Diagram
Diseases associated with FGF6 recombinant proteinOrgans/Tissues associated with FGF6 recombinant protein
 Disease Name  Pubmed Publications
 Hypertrophy Antibodies  >6 publications with FGF6 and Hypertrophy
 Breast Neoplasms Antibodies  >5 publications with FGF6 and Breast Neoplasms
 Carcinoma Antibodies  >5 publications with FGF6 and Carcinoma
 Prostatic Diseases Antibodies  >3 publications with FGF6 and Prostatic Diseases
 Inflammation Antibodies  >2 publications with FGF6 and Inflammation
 Hyperplasia Antibodies  >2 publications with FGF6 and Hyperplasia
 Respiratory Tract Infections Antibodies  >1 publications with FGF6 and Respiratory Tract Infections
 Urinary Bladder Neoplasms Antibodies  >1 publications with FGF6 and Urinary Bladder Neoplasms
 Lung Neoplasms Antibodies  >1 publications with FGF6 and Lung Neoplasms
 Atrophy Antibodies  >1 publications with FGF6 and Atrophy
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >36 publications with FGF6 and Muscle
 Testis Antibodies  >2 publications with FGF6 and Testis
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