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FGFR-2 recombinant protein :: FGFR-2(IIIb)/Fc Chimera Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS692287
Unit / Price
0.01 mg  /  $185 +1 FREE 8GB USB
0.05 mg  /  $315 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FGFR-2(IIIb)/Fc Chimera, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Soluble FGFR-2(IIIb)Fc Chimera

 Product Synonym Names    Fibroblast growth factor receptor 2, BFR-1, FGFR2IIIb, KGFR
 Product Gene Name   

FGFR-2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    RPSFSLVEDT TLEPEEPPTK YQISQPEVYV AAPGESLEVR CLLKDAAVIS WTKDGVHLGP NNRTVLIGEY LQIKGATPRD SGLYACTASR TVDSETWYFM VNVTDAISSG DDEDDTDGAE DFVSENSNKR APYWTNTEKM EKRLHAVPAA NTVKFRCPAG GNPMPTMRWL KNGKEFKQEH RIGGYKVRNQ HWSLIMESVV PSDKGNYTCV VENEYGSINH TYHLDVVERS PHRPILQAGL PANASTVVGG DVEFCKVYSD AQPHIQWIKH VEKNGSKYGP DGLPYLKVLK HSGINSSNAE VLALFNVTEA DAGEYICKVS NYIGQANQSA WLTVLPKQQA PGREKEITAS PDYLEDPRRA SIEGRGDPEE PKSCDKTHTC PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSREL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
 OMIM    101200
 3D Structure    ModBase 3D Structure for P21802
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 Host    Insect cells
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 Purity/Purification    > 90% by SDS-PAGE & silver stain
 Form/Format    Lyophilized
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 Buffer    PBS
 Stabilizer    None
 Reconstitution    The lyophilized sFGFR-2(IIIb)/Fc is soluble in water and most aqueous buffers and should be reconstituted to a concentration not lower than 50?g/ml.
 Biological Activity    (1) The activity of sFGFR-2(IIIb)/Fc was determined by its ability to inhibit the FGF10-induced proliferation of 4MBr-5 cells. (2) Measured by its binding ability in a functional ELISA. Recombinant human soluble FGFR-2(IIIb)/Fc Chimera bind to immobilized recombinant human FGF-10 (MBS692030).
    
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 Preparation and Storage    Lyophilized samples are stable for greater than six months at 20 degree C to 70 degree C. Reconstituted sFGFR-2(IIIb)/Fc should be stored in working aliquots at -20 degree C.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of FGFR-2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for FGFR-2 recombinant protein

   Background: Recombinant human soluble FGFR-2 (IIIb) was fused via a Xa cleavage site with the Fc part of human IgG1. Human recombinant soluble FGFR-2 (IIIb) is a disulfide-linked homodimeric protein. In the reduced form the glycosylated subunits of sFGFR-2 (IIIb)/human Fc chimera display a molecular mass of about 90 kDa. Fibroblast Growth Factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorigenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors, FGFR-1 to -4 are known. Multiple forms of FGFR-1 to -3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGFR-1 and -2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the isoform. Only the alpha isoform has been identified for FGFR-3 and FGFR-4. Additional splicing events for FGFR-1 to -3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generate FGF receptors with alternative IgIII domains (IIIb and IIIc). A IIIa isoform which is a secreted FGF binding protein containing only the N-terminal half of the IgIII domain plus some intron sequences has also been reported for FGFR-1. Mutations in FGFR-1 to -3 have been found in patients with birth defects involving craniosynostosis.
 Product Categories/Family for FGFR-2 recombinant protein    Recombinant Protein; Soluble Receptors; FGFR-2(IIIb)/Fc Chimera, soluble
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 SDS-PAGE of FGFR-2 recombinant protein    SDS-PAGE analysis of recombinant human soluble FGFR-2(IIIb)/Fc produced in insect cells. Sample was loaded in 10% SDS-polyacrylamide gel under reducing condition and stained with Coomassie blue.
FGFR-2 recombinant protein SDS-PAGE image
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 Testing Data of FGFR-2 recombinant protein    Functional ELISA with recombinant human sFGFR-2(IIIb)/Fc Chimera. Recombinant human FGF-10 was coated at 2ug/ml and sFGFR2(IIIb)/Fc and sFGFR2(IIIc)/Fc were added [1ug/ml each]. FGF-10 binds only to FGFR2(IIIb) and not to FGFR2(IIIc).
FGFR-2 recombinant protein Testing Data image
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 Testing Data of FGFR-2 recombinant protein    Inhibition of FGF10-induced proliferation of 4MBr-5 cells by recombinant human soluble FGFR-2(IIIb)/Fc. sFGFR-2(IIIc)/Fc which do not bind FGF10 show no effect.
FGFR-2 recombinant protein Testing Data image
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NCBI/Uniprot data below describe general gene information for FGFR-2. It may not necessarily be applicable to this product.
 NCBI GI #    221316639
 NCBI GeneID    2263
 NCBI Accession #    NP_075259.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_000141.4 [Other Products]
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 UniProt Primary Accession #    P21802 [Other Products]
 UniProt Secondary Accession #    P18443; Q01742; Q12922; Q14300; Q14301; Q14302; Q14303; Q14304; B4DFC2; E7EVR6; E9PCR0 [Other Products]
 UniProt Related Accession #    P21802 [Other Products]
 Molecular Weight    ~90 kDa
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 NCBI Official Full Name    fibroblast growth factor receptor 2 isoform 1
 NCBI Official Synonym Full Names    fibroblast growth factor receptor 2
 NCBI Official Symbol    FGFR2 [Similar Products]
 NCBI Official Synonym Symbols   
BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM
[Similar Products]
 NCBI Protein Information    fibroblast growth factor receptor 2
 UniProt Protein Name    Fibroblast growth factor receptor 2
 UniProt Synonym Protein Names   
K-sam; KGFR; Keratinocyte growth factor receptor; CD_antigen: CD332
 UniProt Gene Name    FGFR2 [Similar Products]
 UniProt Synonym Gene Names    BEK; KGFR; KSAM; FGFR-2; KGFR [Similar Products]
 UniProt Entry Name    FGFR2_HUMAN
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 UniProt Comments for FGFR-2    FGFR2 iso3: a receptor tyrosine kinase of the highly-conserved FGFR family that binds fibroblast growth factor (FGF). Mutations are associated with many craniosynostotic syndromes and bone malformations. Mutations cause syndromes with defects in facial and limb development, including Crouzon syndrome, Beare-Stevenson cutis gyrata syndrome, Pfeiffer syndrome, Apert syndrome, and Jackson-Weiss syndrome. Somatic mutations seen in gastric cancer. Amplified in gastric, breast and some B cell cancers, but deleted in glioblastoma Twenty splice-variant isoforms have been described.

Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor)

Cellular Component: cell cortex; cell surface; cytoplasm; excitatory synapse; extracellular matrix; integral to plasma membrane; intracellular membrane-bound organelle; nucleoplasm; nucleus; plasma membrane

Molecular Function: 1-phosphatidylinositol-3-kinase activity; fibroblast growth factor binding; fibroblast growth factor receptor activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein homodimerization activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity

Biological Process: alveolus development; angiogenesis; axonogenesis; bone mineralization; branching morphogenesis of a nerve; cell fate commitment; cell-cell signaling; embryonic cranial skeleton morphogenesis; embryonic digestive tract morphogenesis; embryonic organ development; embryonic organ morphogenesis; embryonic pattern specification; epidermis morphogenesis; epithelial cell differentiation; fibroblast growth factor receptor signaling pathway; gland morphogenesis; gut development; hair follicle morphogenesis; in utero embryonic development; inner ear morphogenesis; lacrimal gland development; limb bud formation; lung development; MAPKKK cascade; mesenchymal cell differentiation; midbrain development; morphogenesis of embryonic epithelium; multicellular organism growth; negative regulation of transcription from RNA polymerase II promoter; neuroblast division in the ventricular zone; odontogenesis; orbitofrontal cortex development; organ growth; organ morphogenesis; otic vesicle formation; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; positive regulation of cardiac muscle cell proliferation; positive regulation of cell cycle; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of MAPKKK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of Wnt receptor signaling pathway; post-embryonic development; protein amino acid autophosphorylation; pyramidal neuron development; regulation of cell fate commitment; regulation of fibroblast growth factor receptor signaling pathway; regulation of multicellular organism growth; regulation of osteoblast differentiation; regulation of osteoblast proliferation; regulation of phosphoinositide 3-kinase cascade; regulation of smooth muscle cell differentiation; regulation of smoothened signaling pathway; reproductive structure development; skeletal morphogenesis; ureteric bud development; ventricular cardiac muscle morphogenesis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FGFR-2 recombinant proteinPathways associated with FGFR-2 recombinant protein
 Reference Product  PubMed Publications
 FGF2 recombinant protein  >385 publications with FGFR-2 and FGF2
 FGF7 recombinant protein  >276 publications with FGFR-2 and FGF7
 FGF10 recombinant protein  >188 publications with FGFR-2 and FGF10
 FGF1 recombinant protein  >133 publications with FGFR-2 and FGF1
 FGF9 recombinant protein  >56 publications with FGFR-2 and FGF9
 FGF4 recombinant protein  >56 publications with FGFR-2 and FGF4
 FGF8 recombinant protein  >50 publications with FGFR-2 and FGF8
 FGF3 recombinant protein  >36 publications with FGFR-2 and FGF3
 GRB2 recombinant protein  >16 publications with FGFR-2 and GRB2
 FGF6 recombinant protein  >9 publications with FGFR-2 and FGF6
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activated Point Mutants Of FGFR2 Pathway antibodies  Activated Point Mutants Of FGFR2 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Constitutive Signaling By Aberrant PI3K In Cancer Pathway antibodies  Constitutive Signaling By Aberrant PI3K In Cancer Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
Diseases associated with FGFR-2 recombinant proteinOrgans/Tissues associated with FGFR-2 recombinant protein
 Disease Name  Pubmed Publications
 Craniofacial Abnormalities Antibodies  >446 publications with FGFR-2 and Craniofacial Abnormalities
 Craniosynostoses Antibodies  >356 publications with FGFR-2 and Craniosynostoses
 Skin Diseases Antibodies  >287 publications with FGFR-2 and Skin Diseases
 Breast Neoplasms Antibodies  >248 publications with FGFR-2 and Breast Neoplasms
 Limb Deformities, Congenital Antibodies  >235 publications with FGFR-2 and Limb Deformities, Congenital
 Pfeiffer type acrocephalosyndactyly Antibodies  >217 publications with FGFR-2 and Pfeiffer type acrocephalosyndactyly
 Acrocephalosyndactylia Antibodies  >217 publications with FGFR-2 and Acrocephalosyndactylia
 Craniofacial Dysostosis Antibodies  >105 publications with FGFR-2 and Craniofacial Dysostosis
 Abnormalities, Multiple Antibodies  >92 publications with FGFR-2 and Abnormalities, Multiple
 Stomach Neoplasms Antibodies  >80 publications with FGFR-2 and Stomach Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >311 publications with FGFR-2 and Bone
 Embryonic Tissue Antibodies  >218 publications with FGFR-2 and Embryonic Tissue
 Brain Antibodies  >173 publications with FGFR-2 and Brain
 Lung Antibodies  >169 publications with FGFR-2 and Lung
 Skin Antibodies  >146 publications with FGFR-2 and Skin
 Vascular Antibodies  >140 publications with FGFR-2 and Vascular
 Stomach Antibodies  >100 publications with FGFR-2 and Stomach
 Prostate Antibodies  >93 publications with FGFR-2 and Prostate
 Muscle Antibodies  >84 publications with FGFR-2 and Muscle
 Eye Antibodies  >84 publications with FGFR-2 and Eye
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