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FGFR1OP recombinant protein :: FGFR1 Oncogene Partner Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144619 FGFR1OP recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $5,015 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FGFR1 Oncogene Partner (FGFR1OP), Recombinant Protein

 Also Known As   

Recombinant Human FGFR1 Oncogene Partner

 Product Synonym Names    FGFR1OP Human; FGFR1 Oncogene Partner Human Recombinant; FGFR1 oncogene partner; FGFR1OP; FOP
 Product Gene Name   

FGFR1OP recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MGSHMA ATAA AVVAEEDTEL RDLLVQTLEN SGVLNRIKAE LRAAVFLALE EQEKVENKTP LVNESLKKFL NTKDGRLVAS LVAEFLQFFN LDFTLAVFQP ETSTLQGLEG RENLARDLGI IEAEGTVGGP LLLEVIRRCQ QKEKGPTTGE GALDLSDVHS PPKSPEGKTS AQTTPSKKAN DEANQSDTSV SLSEPKSKSS LHLLSHETKI GSFLSNRTLD GKDKAGLCPD EDDMEGDSFF DDPIPKPEKT YGLRKEPRKQ AGSLASLSDA PPLKSGLSSL AGAPSLKDSE SKRGNTVLKD LKLISDKIGS LGLGTGEDDD YVDDFNSTSH RSEKSEISIG EEIEEDLSVE IDDINTSDKL DDLTQDLTVS QLSDVADYLE DVA
 OMIM    605392
 3D Structure    ModBase 3D Structure for O95684
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 Host    E Coli
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 Purity/Purification    Greater than 85.0% as determined by SDS-PAGE.
 Form/Format    FGFR1OP protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 1mM DTT.
Sterile filtered colorless solution.
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 Other Notes    Small volumes of FGFR1OP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for FGFR1OP recombinant protein

   Description: FGFR1OP Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 403 amino acids (1-379 a.a) and having a molecular mass of 43.5kDa.FGFR1OP is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: FGFR1 oncogene partner (FGFR1OP) is a member of the FGFR1OP family. The FGFR1OP protein is an essentially hydrophilic protein proposed to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing the FGFR1OP gene and the FGFR1 gene, is seen in cases of myeloproliferative disorder. The ensuing chimeric protein contains the N-terminal leucine-rich region of the FGFR1OP protein fused to the catalytic domain of FGFR1. The FGFR1OP gene is believed to play a significant role in normal proliferation and differentiation of the erythroid lineage.
 Product Categories/Family for FGFR1OP recombinant protein    PROTEIN KINASES; Enzymes; FGF Receptors
NCBI/Uniprot data below describe general gene information for FGFR1OP. It may not necessarily be applicable to this product.
 NCBI GI #    5901954
 NCBI GeneID    11116
 NCBI Accession #    NP_008976.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007045.3 [Other Products]
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 UniProt Primary Accession #    O95684 [Other Products]
 UniProt Secondary Accession #    Q49AI0; Q5R3F6; Q96EW1; A8K1D1; B2R705 [Other Products]
 UniProt Related Accession #    O95684 [Other Products]
 Molecular Weight    16,106 Da
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 NCBI Official Full Name    FGFR1 oncogene partner isoform a
 NCBI Official Synonym Full Names    FGFR1 oncogene partner
 NCBI Official Symbol    FGFR1OP [Similar Products]
 NCBI Official Synonym Symbols   
FOP
[Similar Products]
 NCBI Protein Information    FGFR1 oncogene partner; fibroblast growth factor receptor 1 oncogene partner
 UniProt Protein Name    FGFR1 oncogene partner
 Protein Family    FGFR1 oncogene partner
 UniProt Gene Name    FGFR1OP [Similar Products]
 UniProt Synonym Gene Names    FOP [Similar Products]
 UniProt Entry Name    FR1OP_HUMAN
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 NCBI Summary for FGFR1OP    This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]
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 UniProt Comments for FGFR1OP    FOP: Required for anchoring microtubules to the centrosomes. A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity. Belongs to the FGFR1OP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 6q27

Cellular Component: centrosome; perinuclear region of cytoplasm; cytosol; nucleus

Molecular Function: protein tyrosine kinase inhibitor activity; protein binding; protein homodimerization activity; protein-tyrosine kinase activity; protein kinase binding

Biological Process: peptidyl-tyrosine phosphorylation; organelle organization and biogenesis; positive regulation of cell proliferation; negative regulation of protein kinase activity; mitotic cell cycle; G2/M transition of mitotic cell cycle; positive regulation of cell growth; positive regulation of cell migration
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 Research Articles on FGFR1OP    1. FOP is a centriolar satellite protein involved in ciliogenesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FGFR1OP recombinant proteinPathways associated with FGFR1OP recombinant protein
 Reference Product  PubMed Publications
 BCR recombinant protein  >4 publications with FGFR1OP and BCR
 FGFR1OP2 recombinant protein  >4 publications with FGFR1OP and FGFR1OP2
 ZMYM2 recombinant protein  >3 publications with FGFR1OP and ZMYM2
 CEP350 recombinant protein  >1 publications with FGFR1OP and CEP350
 Products by Pathway  Pathway Diagram
 Anchoring Of The Basal Body To The Plasma Membrane Pathway antibodies  Anchoring Of The Basal Body To The Plasma Membrane Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Loss Of Nlp From Mitotic Centrosomes Pathway antibodies  Loss Of Nlp From Mitotic Centrosomes Pathway Diagram
 Loss Of Proteins Required For Interphase Microtubule Organizationfrom The Centrosome Pathway antibodies  Loss Of Proteins Required For Interphase Microtubule Organizationfrom The Centrosome Pathway Diagram
 Mitotic G2-G2/M Phases Pathway antibodies  Mitotic G2-G2/M Phases Pathway Diagram
Diseases associated with FGFR1OP recombinant proteinOrgans/Tissues associated with FGFR1OP recombinant protein
 Disease Name  Pubmed Publications
 Hyperplasia Antibodies  >3 publications with FGFR1OP and Hyperplasia
 Atrophy Antibodies  >2 publications with FGFR1OP and Atrophy
 Neoplasms, Experimental Antibodies  >2 publications with FGFR1OP and Neoplasms, Experimental
 Adenocarcinoma Antibodies  >1 publications with FGFR1OP and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >1 publications with FGFR1OP and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >3 publications with FGFR1OP and Bone
 Thyroid Antibodies  >2 publications with FGFR1OP and Thyroid
 Lung Antibodies  >2 publications with FGFR1OP and Lung
 Skin Antibodies  >1 publications with FGFR1OP and Skin
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