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FGFR2 recombinant protein

Scan QR to view Datasheet Catalog #    MBS538160 FGFR2 recombinant protein
Unit / Price
0.05 mg  /  $430 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FGFR2, Recombinant Protein

 Also Known As   

FGFR2 protein (Fc Chimera)

 Product Synonym Names    Fibroblast Growth Factor Receptor 2 protein; FGFR-2 protein (Fc Chimera)
 Product Gene Name   

FGFR2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    101200
 3D Structure    ModBase 3D Structure for P21802
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 Host    Human
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 Purity/Purification    > 90% pure
 Form/Format    Supplied as a lyophilized powder with no preservative. Reconstitute in sterile water to a concentration > 0.05mg/ml.
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 Protein Type    Recombinant
 Biological Significance    Fibroblast Growth Factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorigenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors, FGFR-1 to -4 are known.
 Endotoxin Levels    <0.1 ng per g of sFGF-R2 alpha
 Expression System    Sf-9 insect cells
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 Preparation and Storage    Ships ambient or refrigerated. Upon receipt store at -20 degreeree C.  After reconstituted, store in working aliquots at -20 degreeree C
 Other Notes    Small volumes of FGFR2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for FGFR2 recombinant protein

   Purified recombinant Human FGFR2 protein (Fc Chimera)
 Product Categories/Family for FGFR2 recombinant protein    Cytokines & Growth Factors
 Applications Tested/Suitable for FGFR2 recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for FGFR2. It may not necessarily be applicable to this product.
 NCBI GI #    1296625
 NCBI GeneID    2263
 NCBI Accession #    CAA96492.1 [Other Products]
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 UniProt Primary Accession #    P21802 [Other Products]
 UniProt Secondary Accession #    P18443; Q01742; Q12922; Q14300; Q14301; Q14302; Q14303; Q14304; B4DFC2; E7EVR6; E9PCR0 [Other Products]
 UniProt Related Accession #    P21802 [Other Products]
 Molecular Weight    170 kDa (dimer, glycosylated)
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 NCBI Official Full Name    FGFR2
 NCBI Official Synonym Full Names    fibroblast growth factor receptor 2
 NCBI Official Symbol    FGFR2 [Similar Products]
 NCBI Official Synonym Symbols   
BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM
[Similar Products]
 NCBI Protein Information    fibroblast growth factor receptor 2
 UniProt Protein Name    Fibroblast growth factor receptor 2
 UniProt Synonym Protein Names   
K-sam; KGFR; Keratinocyte growth factor receptor; CD_antigen: CD332
 Protein Family    Fibroblast growth factor receptor
 UniProt Gene Name    FGFR2 [Similar Products]
 UniProt Synonym Gene Names    BEK; KGFR; KSAM; FGFR-2; KGFR [Similar Products]
 UniProt Entry Name    FGFR2_HUMAN
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 NCBI Summary for FGFR2    The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
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 UniProt Comments for FGFR2    FGFR2: a receptor tyrosine kinase of the highly-conserved FGFR family that binds fibroblast growth factor (FGF). Mutations are associated with many craniosynostotic syndromes and bone malformations. Mutations cause syndromes with defects in facial and limb development, including Crouzon syndrome, Beare-Stevenson cutis gyrata syndrome, Pfeiffer syndrome, Apert syndrome, and Jackson-Weiss syndrome. Somatic mutations seen in gastric cancer. Amplified in gastric, breast and some B cell cancers, but deleted in glioblastoma Twenty splice-variant isoforms have been described.

Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Oncoprotein; TK group; FGFR family

Chromosomal Location of Human Ortholog: 10q26

Cellular Component: Golgi apparatus; cell surface; intracellular membrane-bound organelle; integral to plasma membrane; cytoplasmic membrane-bound vesicle; extracellular region; integral to membrane; excitatory synapse; cell cortex; nucleoplasm; extracellular matrix; membrane; cytoplasm; plasma membrane; nucleus

Molecular Function: heparin binding; protein binding; protein homodimerization activity; fibroblast growth factor binding; fibroblast growth factor receptor activity; protein-tyrosine kinase activity; ATP binding

Biological Process: nerve growth factor receptor signaling pathway; mesodermal cell differentiation; embryonic pattern specification; post-embryonic development; embryonic organ morphogenesis; morphogenesis of embryonic epithelium; cell-cell signaling; embryonic digestive tract morphogenesis; midbrain development; positive regulation of mesenchymal cell proliferation; ventricular cardiac muscle morphogenesis; neuromuscular junction development; positive regulation of cardiac muscle cell proliferation; inner ear morphogenesis; cell fate commitment; fibroblast growth factor receptor signaling pathway; regulation of osteoblast differentiation; regulation of fibroblast growth factor receptor signaling pathway; positive regulation of cell cycle; embryonic cranial skeleton morphogenesis; neuroblast division in the ventricular zone; organ growth; organ morphogenesis; mesenchymal cell differentiation; positive regulation of cell division; negative regulation of mitosis; embryonic organ development; gland morphogenesis; positive regulation of transcription from RNA polymerase II promoter; alveolus development; positive regulation of epithelial cell proliferation; peptidyl-tyrosine phosphorylation; branching morphogenesis of a nerve; apoptosis; positive regulation of smooth muscle cell proliferation; protein amino acid autophosphorylation; pyramidal neuron development; negative regulation of transcription from RNA polymerase II promoter; orbitofrontal cortex development; bone mineralization; odontogenesis; regulation of osteoblast proliferation; positive regulation of MAPKKK cascade; epithelial cell differentiation; ureteric bud development; epidermis morphogenesis; positive regulation of cell proliferation; regulation of smooth muscle cell differentiation; lacrimal gland development; angiogenesis; otic vesicle formation; positive regulation of Wnt receptor signaling pathway; negative regulation of epithelial cell proliferation; epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; hair follicle morphogenesis; in utero embryonic development; multicellular organism growth; synaptic vesicle transport; regulation of multicellular organism growth; limb bud formation; gut development; axonogenesis; skeletal morphogenesis; regulation of cell fate commitment; insulin receptor signaling pathway; epithelial to mesenchymal transition; innate immune response; reproductive structure development; lung development; regulation of smoothened signaling pathway

Disease: Pfeiffer Syndrome; Lacrimoauriculodentodigital Syndrome; Scaphocephaly, Maxillary Retrusion, And Mental Retardation; Apert Syndrome; Gastric Cancer; Jackson-weiss Syndrome; Beare-stevenson Cutis Gyrata Syndrome; Crouzon Syndrome; Bent Bone Dysplasia Syndrome; Antley-bixler Syndrome Without Genital Anomalies Or Disordered Steroidogenesis; Saethre-chotzen Syndrome
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 Research Articles on FGFR2    1. Activating FGFR2-RAS-BRAF mutations play a critical role in the pathogenesis of most cases of ameloblastoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with FGFR2 recombinant proteinDiseases associated with FGFR2 recombinant protein
 Products by Pathway  Pathway Diagram
 Activated Point Mutants Of FGFR2 Pathway antibodies  Activated Point Mutants Of FGFR2 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Constitutive Signaling By Aberrant PI3K In Cancer Pathway antibodies  Constitutive Signaling By Aberrant PI3K In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
 Disease Name  Pubmed Publications
 Craniofacial Abnormalities Antibodies  >426 publications with FGFR2 and Craniofacial Abnormalities
 Craniosynostoses Antibodies  >345 publications with FGFR2 and Craniosynostoses
 Skin Diseases Antibodies  >269 publications with FGFR2 and Skin Diseases
 Breast Neoplasms Antibodies  >234 publications with FGFR2 and Breast Neoplasms
 Limb Deformities, Congenital Antibodies  >231 publications with FGFR2 and Limb Deformities, Congenital
 Pfeiffer type acrocephalosyndactyly Antibodies  >213 publications with FGFR2 and Pfeiffer type acrocephalosyndactyly
 Acrocephalosyndactylia Antibodies  >213 publications with FGFR2 and Acrocephalosyndactylia
 Craniofacial Dysostosis Antibodies  >101 publications with FGFR2 and Craniofacial Dysostosis
 Abnormalities, Multiple Antibodies  >88 publications with FGFR2 and Abnormalities, Multiple
 Stomach Neoplasms Antibodies  >68 publications with FGFR2 and Stomach Neoplasms
Organs/Tissues associated with FGFR2 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >298 publications with FGFR2 and Bone
 Embryonic Tissue Antibodies  >217 publications with FGFR2 and Embryonic Tissue
 Brain Antibodies  >160 publications with FGFR2 and Brain
 Lung Antibodies  >158 publications with FGFR2 and Lung
 Skin Antibodies  >138 publications with FGFR2 and Skin
 Vascular Antibodies  >132 publications with FGFR2 and Vascular
 Prostate Antibodies  >90 publications with FGFR2 and Prostate
 Stomach Antibodies  >88 publications with FGFR2 and Stomach
 Muscle Antibodies  >84 publications with FGFR2 and Muscle
 Eye Antibodies  >81 publications with FGFR2 and Eye
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