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FHIT recombinant protein

Scan QR to view Datasheet Catalog #    MBS306032 FHIT recombinant protein
Unit / Price
0.01 mg  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FHIT, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human FHIT Protein

 Product Gene Name   

FHIT recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Characterization    On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 43kDa.
 Source    Recombinant full length human FHIT protein expressed in E Coli.
 Domain    full length
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 Preparation and Storage    Store at -20 degree to -80 degree C. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
 Other Notes    Small volumes of FHIT recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for FHIT. It may not necessarily be applicable to this product.
 NCBI GI #    122056451
 NCBI Accession #    ABM66092.1 [Other Products]
 Molecular Weight    3,844 Da
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 NCBI Official Full Name    FHIT, partial
 UniProt Protein Name    Diadenosine triphosphate hydrolase
 UniProt Synonym Protein Names   
Diadenosine triphosphate hydrolase
 Protein Family    Bis(5'-adenosyl)-triphosphatase
 UniProt Gene Name    FHIT [Similar Products]
 UniProt Entry Name    Q71VB2_HUMAN
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 NCBI Summary for FHIT    This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
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 UniProt Comments for FHIT    FHIT: a member of the histidine triad gene family. A diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. Its gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. A possible tumor suppressor in specific tissues. Phospho-FHIT observed in liver and kidney, but not in brain and lung. Phospho-FHIT undetected in all tested human tumor cell lines. Aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas.

Protein type: Hydrolase; Motility/polarity/chemotaxis; EC 3.6.1.29; Tumor suppressor; DNA replication; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 3p14.2

Cellular Component: mitochondrion; cytoplasm; cytosol; nucleus

Molecular Function: identical protein binding; protein binding; hydrolase activity; ubiquitin protein ligase binding; bis(5'-adenosyl)-triphosphatase activity; nucleotide binding; catalytic activity

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleotide metabolic process; DNA replication; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; purine nucleotide metabolic process
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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