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FKBP12 recombinant protein

Scan QR to view Datasheet Catalog #    MBS2546371
SDS-PAGE
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
0.2 mg  /  $525 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FKBP12, Recombinant Protein

 Also Known As   

Recombinant Human FKBP12 Protein (His tag)

 Product Synonym Names    FKBP1A, RP11-314N13.2, FKBP-12, FKBP1, FKBP12, FKBP12C, PKC12, PKCI2, PPIASE
 Product Gene Name   

FKBP12 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M34539 mRNA
 3D Structure    ModBase 3D Structure for P62942
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 Host    E Coli
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 Purity/Purification    > 96 % as determined by SDS-PAGE
 Form/Format    Lyophilized from sterile PBS, 10% glycerol, pH 7.4
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 Predicted N Terminal    Met 1
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 Preparation and Storage    Samples are stable for up to twelve months from date of receipt at -70 degree C
 Other Notes    Small volumes of FKBP12 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for FKBP12 recombinant protein

   Background: FK506 binding protein 12 (FKBP12), also known as FKBP1, along with cyclophilin, are two major members of the immunophilin protein family who serve as receptors for the immunosuppressant drugs cyclosporin A and FK506. As a conserved molecules in many eukaryotes, FKBP12 has been characterized as a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans-proline residues, and is involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription. FKBP12 has attracted immense attention and its role in mediating the immunosuppressive functions. FKBP12 serves a dual role as a peptidyl-prolyl cis-trans isomerase and as a modulator of several cell signaling pathways. In one such a role, FKBP12 interacts with and regulates the functional state of the ryanodine Ca2+ channel receptor by altering protein conformation and coordinating multi-protein complex formation. Another physiological role of FKBP12 is an interactor and a regulator of the type I serine/threonine kinase receptors of TGF-beta superfamily. Current data, derived from detailed biochemical studies as well as from functional studies in various systems, suggest that FKBP12 functions as a "guardian" for the type I receptors to prevent them from leaky signaling under sub-optimal ligand concentrations, thereby providing a molecular "gradient reader" for TGF-beta family morphogens. This aspect of FKBP12 function may be critical for cellular responsiveness to morphogenetic gradients of the TGF-beta family members during early development, serving to assure the translation of different ligand concentrations into different signaling readouts. In addition, FKBP12 may be involved in neuronal or astrocytic cytoskeletal organization and in the abnormal metabolism of tau protein in Alzheimer's disease (AD) damaged neurons.

Description: A DNA sequence encoding the human FKBP12 (NP_463460) (Met 1-Glu 108) was expressed with a C-terminal polyhistidine tag.
 Application Notes for FKBP12 recombinant protein    The recombinant human FKBP12 consists of 114 amino acids and predicts a molecular mass of 12.9 kDa as estimated by SDS-PAGE.
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 SDS-PAGE of FKBP12 recombinant protein    FKBP12 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for FKBP12. It may not necessarily be applicable to this product.
 NCBI GI #    17149836
 NCBI GeneID    2280
 NCBI Accession #    NP_463460 [Other Products]
 NCBI GenBank Nucleotide #    NM_054014.3 [Other Products]
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 UniProt Primary Accession #    P62942 [Other Products]
 UniProt Secondary Accession #    P20071; Q4VC47; Q6FGD9; Q6LEU3; Q9H103; Q9H566; D3DVW6 [Other Products]
 UniProt Related Accession #    P62942 [Other Products]
 Molecular Weight    11,951 Da
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 NCBI Official Full Name    peptidyl-prolyl cis-trans isomerase FKBP1A isoform a
 NCBI Official Synonym Full Names    FK506 binding protein 1A
 NCBI Official Symbol    FKBP1A [Similar Products]
 NCBI Official Synonym Symbols   
FKBP1; PKC12; PKCI2; FKBP12; PPIASE; FKBP-12; FKBP-1A
[Similar Products]
 NCBI Protein Information    peptidyl-prolyl cis-trans isomerase FKBP1A
 UniProt Protein Name    Peptidyl-prolyl cis-trans isomerase FKBP1A
 UniProt Synonym Protein Names   
12 kDa FK506-binding protein; 12 kDa FKBP; FKBP-12; Calstabin-1; FK506-binding protein 1A; FKBP-1A; Immunophilin FKBP12; Rotamase
 Protein Family    FKBP12-associated protein
 UniProt Gene Name    FKBP1A [Similar Products]
 UniProt Synonym Gene Names    FKBP1; FKBP12; PPIase FKBP1A; 12 kDa FKBP; FKBP-12; FKBP-1A [Similar Products]
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 NCBI Summary for FKBP12    The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008]
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 UniProt Comments for FKBP12    FKBP12: an immunophilin and peptidyl-prolyl cis-trans isomerase that binds to the immunosuppressant drugs FK506 (a.k.a. tacrolimus or Fujimycin) and rapamycin (a.k.a. Sirolimus). The FKBP12/rapamycin complex binds NFAT transcription factors and inhibits the induction of T cell genes including IL-2, IL-3, IL-4, TNF-alpha and GM-CSF. FK506 is used in treating patients after organ transplant and those suffering from autoimmune disorders. The immunosuppressant activity of FKBP12 is not apparently related to its prolyl isomerase activity. The FKBP12/rapamycin complex inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding the mTOR Complex1 (mTORC1). mTORC1 contains Raptor, mLST8, and PRAS40, and interacts with DEPTOR, which inhibits its activity. mTOR, a S/T protein kinase, is a central regulator of cellular growth and metabolism. Its inhibition enhances the dependence on aerobic glycolysis in leukemic cells.

Protein type: EC 5.2.1.8; Isomerase

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum membrane; membrane; Z disc

Molecular Function: activin binding; calcium channel inhibitor activity; FK506 binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; signal transducer activity; SMAD binding; transforming growth factor beta receptor binding

Biological Process: 'de novo' protein folding; fibril organization and biogenesis; heart morphogenesis; negative regulation of protein phosphatase type 2B activity; negative regulation of release of sequestered calcium ion into cytosol; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein binding; positive regulation of protein ubiquitination; protein maturation via protein folding; protein peptidyl-prolyl isomerization; protein refolding; regulation of activin receptor signaling pathway; regulation of immune response; regulation of protein localization; SMAD protein complex assembly; transforming growth factor beta receptor signaling pathway; ventricular cardiac muscle morphogenesis
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 Research Articles on FKBP12    1. Findings indicate that mutant huntingtin (mHTT) aggregates can be transformed into benign species by isomerase FKBP12.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FKBP12 recombinant proteinPathways associated with FKBP12 recombinant protein
 Reference Product  PubMed Publications
 MTOR recombinant protein  >6 publications with FKBP12 and MTOR
 RYR1 recombinant protein  >4 publications with FKBP12 and RYR1
 ACVR1 recombinant protein  >2 publications with FKBP12 and ACVR1
 Products by Pathway  Pathway Diagram
 ALK1 Pathway antibodies  ALK1 Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 ALK2 Signaling Events Pathway antibodies  ALK2 Signaling Events Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling In The CD4+ TCR Pathway antibodies  Calcium Signaling In The CD4+ TCR Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Loss Of Function Of SMAD2/3 In Cancer Pathway antibodies  Loss Of Function Of SMAD2/3 In Cancer Pathway Diagram
 Loss Of Function Of SMAD4 In Cancer Pathway antibodies  Loss Of Function Of SMAD4 In Cancer Pathway Diagram
Diseases associated with FKBP12 recombinant proteinOrgans/Tissues associated with FKBP12 recombinant protein
 Disease Name  Pubmed Publications
 Muscular Diseases Antibodies  >4 publications with FKBP12 and Muscular Diseases
 Nervous System Diseases Antibodies  >3 publications with FKBP12 and Nervous System Diseases
 Disease Models, Animal Antibodies  >3 publications with FKBP12 and Disease Models, Animal
 Inflammation Antibodies  >3 publications with FKBP12 and Inflammation
 Cardiomegaly Antibodies  >2 publications with FKBP12 and Cardiomegaly
 Heart Diseases Antibodies  >2 publications with FKBP12 and Heart Diseases
 Urinary Bladder Diseases Antibodies  >1 publications with FKBP12 and Urinary Bladder Diseases
 Hypertrophy Antibodies  >1 publications with FKBP12 and Hypertrophy
 Brain Diseases Antibodies  >1 publications with FKBP12 and Brain Diseases
 Neoplasms, Experimental Antibodies  >1 publications with FKBP12 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >9 publications with FKBP12 and Muscle
 Blood Antibodies  >5 publications with FKBP12 and Blood
 Heart Antibodies  >3 publications with FKBP12 and Heart
 Kidney Antibodies  >3 publications with FKBP12 and Kidney
 Vascular Antibodies  >3 publications with FKBP12 and Vascular
 Bone Antibodies  >2 publications with FKBP12 and Bone
 Lung Antibodies  >2 publications with FKBP12 and Lung
 Brain Antibodies  >2 publications with FKBP12 and Brain
 Bladder Antibodies  >1 publications with FKBP12 and Bladder
 Eye Antibodies  >1 publications with FKBP12 and Eye
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