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FSCN1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203522
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FSCN1, Recombinant Protein

★Popular Item★
 Also Known As   

FSCN1, 1-493aa, Human, His tag, E Coli

 Product Synonym Names    Fascin; FAN1; HSN; SNL; Fascin
 Product Gene Name   

FSCN1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MTANGTAEAV QIQFGLINCG NKYLTAEAFG FKVNASASSL KKKQIWTLEQ PPDEAGSAAV CLRSHLGRYL AADKDGNVTC EREVPGPDCR FLIVAHDDGR WSLQSEAHRR YFGGTEDRLS CFAQTVSPAE KWSVHIAMHP QVNIYSVTRK RYAHLSARPA DEIAVDRDVP WGVDSLITLA FQDQRYSVQT ADHRFLRHDG RLVARPEPAT GYTLEFRSGK VAFRDCEGRY LAPSGPSGTL KAGKATKVGK DELFALEQSC AQVVLQAANE RNVSTRQGMD LSANQDEETD QETFQLEIDR DTKKCAFRTH TGKYWTLTAT GGVQSTASSK NASCYFDIEW RDRRITLRAS NGKFVTSKKN GQLAASVETA GDSELFLMKL INRPIIVFRG EHGFIGCRKV TGTLDANRSS YDVFQLEFND GAYNIKDSTG KYWTVGSDSA VTSSGDTPVD FFFEFCDYNK VAIKVGGRYL KGDHAGVLKA SAETVDPASL WEY
 OMIM    U03057 mRNA
 3D Structure    ModBase 3D Structure for Q16658
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol, 2mM DTT, 100mM NaCl
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of FSCN1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for FSCN1 recombinant protein

   FSCN1 is an actin-bundling protein that provides rigidity to filopodial bundles to efficiently push the membrane forward during cytoskeleton remodeling and cell migration. Probably involved in the assembly of actin filament bundles present in microspikes, membrane ruffles, and stress fibers. And this protein is absent from most normal epithelia yet is upregulated in multiple forms of human carcinoma, where its expression correlates clinically with a poor prognosis. FSCN1 expression has been localized to neurons, glial cells, and endothelial cells. Recombinant human FSCN1 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for FSCN1 recombinant protein    Cytoskeleton
 Applications Tested/Suitable for FSCN1 recombinant protein   

SDS-PAGE

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 SDS-Page of FSCN1 recombinant protein    FSCN1 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for FSCN1. It may not necessarily be applicable to this product.
 NCBI GI #    4507115
 NCBI GeneID    6624
 NCBI Accession #    NP_003079 [Other Products]
 NCBI GenBank Nucleotide #    NM_003088.3 [Other Products]
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 UniProt Primary Accession #    Q16658 [Other Products]
 UniProt Secondary Accession #    Q96IC5; Q96IH1; Q9BRF1; A6NI89; B2RE97 [Other Products]
 UniProt Related Accession #    Q16658 [Other Products]
 Molecular Weight    56.7kDa (513aa)
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 NCBI Official Full Name    fascin
 NCBI Official Synonym Full Names    fascin actin-bundling protein 1
 NCBI Official Symbol    FSCN1 [Similar Products]
 NCBI Official Synonym Symbols   
HSN; SNL; p55; FAN1
[Similar Products]
 NCBI Protein Information    fascin
 UniProt Protein Name    Fascin
 UniProt Synonym Protein Names   
55 kDa actin-bundling protein; Singed-like protein; p55
 Protein Family    Fascin
 UniProt Gene Name    FSCN1 [Similar Products]
 UniProt Synonym Gene Names    FAN1; HSN; SNL [Similar Products]
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 NCBI Summary for FSCN1    This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
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 UniProt Comments for FSCN1    Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.
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Product References and Citations for FSCN1 recombinant protein

   Wu D, et al. (2010) Ann Oncol. 21 (3):589-96; Shin H, et al. (2009) Phys Rev Left 103 (23):238102;
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 Research Articles on FSCN1    1. MYC-nick, fascin, and Cdc42 are frequently up-regulated in cells present at the invasive front of human colorectal tumors, suggesting a coordinated role for these proteins in tumor migration.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FSCN1 recombinant proteinPathways associated with FSCN1 recombinant protein
 Reference Product  PubMed Publications
 GSN recombinant protein  >1 publications with FSCN1 and GSN
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-4 And 13 Signaling Pathway antibodies  Interleukin-4 And 13 Signaling Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 Signaling By Interleukins Pathway antibodies  Signaling By Interleukins Pathway Diagram
Diseases associated with FSCN1 recombinant proteinOrgans/Tissues associated with FSCN1 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >37 publications with FSCN1 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >17 publications with FSCN1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >16 publications with FSCN1 and Lung Neoplasms
 Lung Diseases Antibodies  >12 publications with FSCN1 and Lung Diseases
 Urinary Bladder Neoplasms Antibodies  >10 publications with FSCN1 and Urinary Bladder Neoplasms
 Ovarian Neoplasms Antibodies  >8 publications with FSCN1 and Ovarian Neoplasms
 Liver Neoplasms Antibodies  >7 publications with FSCN1 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >6 publications with FSCN1 and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >5 publications with FSCN1 and Neoplasms, Experimental
 Liver Diseases Antibodies  >5 publications with FSCN1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >22 publications with FSCN1 and Lung
 Lymph Node Antibodies  >19 publications with FSCN1 and Lymph Node
 Blood Antibodies  >13 publications with FSCN1 and Blood
 Stomach Antibodies  >12 publications with FSCN1 and Stomach
 Bladder Antibodies  >10 publications with FSCN1 and Bladder
 Liver Antibodies  >8 publications with FSCN1 and Liver
 Brain Antibodies  >8 publications with FSCN1 and Brain
 Bone Antibodies  >5 publications with FSCN1 and Bone
 Vascular Antibodies  >5 publications with FSCN1 and Vascular
 Muscle Antibodies  >4 publications with FSCN1 and Muscle
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