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Fancd2 recombinant protein :: Fanconi anemia group D2 protein homolog (Fancd2), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1470656 Fancd2 recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $1,045 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,045 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,275 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,275 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,600 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,600 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,055 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,055 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fanconi anemia group D2 protein homolog (Fancd2), partial, Recombinant Protein

 Also Known As   

Recombinant Rat Fanconi anemia group D2 protein homolog (Fancd2), partial

 Product Synonym Names    Fanconi anemia group D2 protein homolog; Protein FACD2
 Product Gene Name   

Fancd2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q6IV68
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rattus norvegicus (Rat)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Fancd2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Fancd2 recombinant protein

   The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms.
NCBI/Uniprot data below describe general gene information for Fancd2. It may not necessarily be applicable to this product.
 NCBI GI #    48843737
 NCBI GeneID    312641
 NCBI Accession #    NP_001001719.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001001719.1 [Other Products]
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 UniProt Primary Accession #    Q6IV68 [Other Products]
 UniProt Related Accession #    Q6IV68 [Other Products]
 Molecular Weight    163,621 Da
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 NCBI Official Full Name    Fanconi anemia group D2 protein homolog
 NCBI Official Synonym Full Names    Fanconi anemia, complementation group D2
 NCBI Official Symbol    Fancd2 [Similar Products]
 NCBI Protein Information    Fanconi anemia group D2 protein homolog; Fanconi anemia D2 protein
 UniProt Protein Name    Fanconi anemia group D2 protein homolog
 Protein Family    Fanconi anemia group D2 protein
 UniProt Gene Name    Fancd2 [Similar Products]
 UniProt Synonym Gene Names    Protein FACD2 [Similar Products]
 UniProt Entry Name    FACD2_RAT
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 UniProt Comments for Fancd2    FANCD2: Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching. Interacts directly with FANCE and FANCI. Interacts with USP1 and MEN1. The ubiquitinated form specifically interacts with BRCA1 and BLM. Both the nonubiquitinated and the monoubiquitinated forms interact with BRCA2; this interaction is mediated by phosphorylated FANCG and the complex also includes XCCR3. The ubiquitinated form specifically interacts with MTMR15/FAN1 (via UBZ-type zinc finger), leading to recruit MTMR15/FAN1 to sites of DNA damage. Interacts with DCLRE1B/Apollo. Highly expressed in germinal center cells of the spleen, tonsil, and reactive lymph nodes, and in the proliferating basal layer of squamous epithelium of tonsil, esophagus, oropharynx, larynx and cervix. Expressed in cytotrophoblastic cells of the placenta and exocrine cells of the pancreas. Highly expressed in testis, where expression is restricted to maturing spermatocytes. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA repair, damage

Cellular Component: nucleoplasm; Golgi apparatus; intracellular membrane-bound organelle; condensed chromosome; nucleus

Biological Process: gamete generation; synapsis; response to gamma radiation; DNA repair; response to DNA damage stimulus
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Fancd2 recombinant proteinPathways associated with Fancd2 recombinant protein
 Reference Product  PubMed Publications
 Brca1 recombinant protein  >134 publications with Fancd2 and Brca1
 Brca2 recombinant protein  >113 publications with Fancd2 and Brca2
 Fancc recombinant protein  >87 publications with Fancd2 and Fancc
 FANCI recombinant protein  >81 publications with Fancd2 and FANCI
 Fancl recombinant protein  >50 publications with Fancd2 and Fancl
 Fance recombinant protein  >37 publications with Fancd2 and Fance
 Usp1 recombinant protein  >17 publications with Fancd2 and Usp1
 Ube2t recombinant protein  >10 publications with Fancd2 and Ube2t
 Men1 recombinant protein  >4 publications with Fancd2 and Men1
 Products by Pathway  Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Regulation Of The Fanconi Anemia Pathway antibodies  Regulation Of The Fanconi Anemia Pathway Diagram
 TNF-alpha NF-kB Signaling Pathway antibodies  TNF-alpha NF-kB Signaling Pathway Diagram
Diseases associated with Fancd2 recombinant proteinOrgans/Tissues associated with Fancd2 recombinant protein
 Disease Name  Pubmed Publications
 Anemia Antibodies  >533 publications with Fancd2 and Anemia
 Fanconi Anemia Antibodies  >533 publications with Fancd2 and Fanconi Anemia
 FANCONI ANEMIA, COMPLEMENTATION GROUP D2 Antibodies  >370 publications with Fancd2 and FANCONI ANEMIA, COMPLEMENTATION GROUP D2
 Breast Neoplasms Antibodies  >39 publications with Fancd2 and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >27 publications with Fancd2 and Ovarian Neoplasms
 Ovarian Diseases Antibodies  >22 publications with Fancd2 and Ovarian Diseases
 Carcinoma, Squamous Cell Antibodies  >20 publications with Fancd2 and Carcinoma, Squamous Cell
 Head and Neck Neoplasms Antibodies  >18 publications with Fancd2 and Head and Neck Neoplasms
 Nervous System Diseases Antibodies  >12 publications with Fancd2 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >12 publications with Fancd2 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >16 publications with Fancd2 and Lung
 Liver Antibodies  >7 publications with Fancd2 and Liver
 Testis Antibodies  >5 publications with Fancd2 and Testis
 Brain Antibodies  >5 publications with Fancd2 and Brain
 Heart Antibodies  >4 publications with Fancd2 and Heart
 Embryonic Tissue Antibodies  >3 publications with Fancd2 and Embryonic Tissue
 Pancreas Antibodies  >1 publications with Fancd2 and Pancreas
 Prostate Antibodies  >1 publications with Fancd2 and Prostate
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