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FDPS recombinant protein :: Farnesyl pyrophosphate synthase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS954245
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $135 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $255 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $420 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $665 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $935 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,065 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,090 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,260 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,310 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,350 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,420 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,725 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,940 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,985 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,165 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,555 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Farnesyl pyrophosphate synthase (FDPS), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Farnesyl pyrophosphate synthase

 Product Synonym Names    (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase (EC:2.5.1.1); Farnesyl diphosphate synthase; Geranyltranstransferase
 Product Gene Name   

FDPS recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-419aa; Full Length
 Sequence    MPLSRWLRSV GVFLLPAPYW APRERWLGSL RRPSLVHGYP VLAWHSARCW CQAWTEEPRA LCSSLRMNGD QNSDVYAQEK QDFVQHFSQI VRVLTEDEMG HPEIGDAIAR LKEVLEYNAI GGKYNRGLTV VVAFRELVEP RKQDADSLQR AWTVGWCVEL LQAFFLVADD IMDSSLTRRG QICWYQKPGV GLDAINDANL LEACIYRLLK LYCREQPYYL NLIELFLQSS YQTEIGQTLD LLTAPQGNVD LVRFTEKRYK SIVKYKTAFY SFYLPIAAAM YMAGIDGEKE HANAKKILLE MGEFFQIQDD YLDLFGDPSV TGKIGTDIQD NKCSWLVVQC LQRATPEQYQ ILKENYGQKE AEKVARVKAL YEELDLPAVF LQYEEDSYSH IMALIEQYAA PLPPAVFLGL ARKIYKRRK
 OMIM    134629
 3D Structure    ModBase 3D Structure for P14324
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of FDPS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for FDPS recombinant protein

   Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
 Product Categories/Family for FDPS recombinant protein    Metabolism
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 SDS-PAGE of FDPS recombinant protein    FDPS recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for FDPS. It may not necessarily be applicable to this product.
 NCBI GI #    209571582
 NCBI GeneID    2224
 NCBI Accession #    NP_001129293.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001135821.1 [Other Products]
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 UniProt Primary Accession #    P14324 [Other Products]
 UniProt Secondary Accession #    Q96G29; D3DV91; E9PCI9 [Other Products]
 UniProt Related Accession #    P14324 [Other Products]
 Molecular Weight    64.24kD
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 NCBI Official Full Name    farnesyl pyrophosphate synthase isoform a
 NCBI Official Synonym Full Names    farnesyl diphosphate synthase
 NCBI Official Symbol    FDPS [Similar Products]
 NCBI Official Synonym Symbols   
FPS; FPPS
[Similar Products]
 NCBI Protein Information    farnesyl pyrophosphate synthase
 UniProt Protein Name    Farnesyl pyrophosphate synthase
 UniProt Synonym Protein Names   
(2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase (EC:2.5.1.1); Farnesyl diphosphate synthase; Geranyltranstransferase
 Protein Family    Farnesyl pyrophosphate synthase
 UniProt Gene Name    FDPS [Similar Products]
 UniProt Synonym Gene Names    FPS; KIAA1293; FPP synthase; FPS [Similar Products]
 UniProt Entry Name    FPPS_HUMAN
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 NCBI Summary for FDPS    This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]
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 UniProt Comments for FDPS    FDPS: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. Belongs to the FPP/GGPP synthase family.

Protein type: EC 2.5.1.1; Transferase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; EC 2.5.1.10; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: cytoplasm; cytosol; mitochondrion; nucleoplasm

Molecular Function: dimethylallyltranstransferase activity; geranyltranstransferase activity; metal ion binding

Biological Process: cholesterol biosynthetic process; farnesyl diphosphate biosynthetic process; geranyl diphosphate biosynthetic process; viral reproduction
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Product References and Citations for FDPS recombinant protein

   "Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase by phorbol ester." Wilkin D.J., Kutsunai S.Y., Edwards P.A. J. Biol. Chem. 265:4607-4614(1990)
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 Research Articles on FDPS    1. These results are consistent with the previously proposed hypothesis that the allosteric pocket of human FPPS, located near the active site, plays a feed-back regulatory role for this enzyme.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FDPS recombinant proteinPathways associated with FDPS recombinant protein
 Reference Product  PubMed Publications
 IDI1 recombinant protein  >6 publications with FDPS and IDI1
 FDFT1 recombinant protein  >5 publications with FDPS and FDFT1
 MVD recombinant protein  >4 publications with FDPS and MVD
 SREBF2 recombinant protein  >2 publications with FDPS and SREBF2
 GGPS1 recombinant protein  >1 publications with FDPS and GGPS1
 Products by Pathway  Pathway Diagram
 Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies  Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
Diseases associated with FDPS recombinant proteinOrgans/Tissues associated with FDPS recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >60 publications with FDPS and Cardiovascular Diseases
 Heart Diseases Antibodies  >20 publications with FDPS and Heart Diseases
 Myocardial Infarction Antibodies  >16 publications with FDPS and Myocardial Infarction
 Inflammation Antibodies  >15 publications with FDPS and Inflammation
 Liver Diseases Antibodies  >12 publications with FDPS and Liver Diseases
 Lung Diseases Antibodies  >12 publications with FDPS and Lung Diseases
 Kidney Diseases Antibodies  >9 publications with FDPS and Kidney Diseases
 Atherosclerosis Antibodies  >9 publications with FDPS and Atherosclerosis
 Fibrosis Antibodies  >7 publications with FDPS and Fibrosis
 Liver Neoplasms Antibodies  >5 publications with FDPS and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >126 publications with FDPS and Blood
 Bone Antibodies  >62 publications with FDPS and Bone
 Mouth Antibodies  >42 publications with FDPS and Mouth
 Liver Antibodies  >36 publications with FDPS and Liver
 Vascular Antibodies  >24 publications with FDPS and Vascular
 Heart Antibodies  >20 publications with FDPS and Heart
 Lung Antibodies  >13 publications with FDPS and Lung
 Muscle Antibodies  >12 publications with FDPS and Muscle
 Kidney Antibodies  >11 publications with FDPS and Kidney
 Brain Antibodies  >9 publications with FDPS and Brain
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