NP_001129293.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
64.3 kDa
NCBI Official Full Name
farnesyl pyrophosphate synthase isoform a
NCBI Official Synonym Full Names
farnesyl diphosphate synthase
NCBI Official Synonym Symbols
NCBI Protein Information
farnesyl pyrophosphate synthase
UniProt Protein Name
Farnesyl pyrophosphate synthase
UniProt Synonym Protein Names
(2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase (EC:2.5.1.1); Farnesyl diphosphate synthase; Geranyltranstransferase
UniProt Synonym Gene Names
UniProt Entry Name
FPPS_HUMAN
NCBI Summary for FDPS
This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]
UniProt Comments for FDPS
FDPS: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. Belongs to the FPP/GGPP synthase family.
Protein type: EC 2.5.1.1; Transferase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; EC 2.5.1.10; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1q22
Cellular Component: cytoplasm; cytosol; mitochondrion; nucleoplasm
Molecular Function: dimethylallyltranstransferase activity; geranyltranstransferase activity; metal ion binding
Biological Process: cholesterol biosynthetic process; farnesyl diphosphate biosynthetic process; geranyl diphosphate biosynthetic process; viral reproduction
Product References and Citations for FDPS recombinant protein
"Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase by phorbol ester."
Wilkin D.J., Kutsunai S.Y., Edwards P.A.
J. Biol. Chem. 265:4607-4614(1990)
Research Articles on FDPS
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with FDPS recombinant protein
Pathways associated with FDPS recombinant protein
Diseases associated with FDPS recombinant protein
Organs/Tissues associated with FDPS recombinant protein
|