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FasL recombinant protein

Scan QR to view Datasheet Catalog #    MBS536558 FasL recombinant protein
Unit / Price
0.01 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FasL, Recombinant Protein

★Popular Item★
 Also Known As   

FasL protein

 Product Synonym Names    Apo I Ligand protein; CD95L protein; TNFSF6 protein; soluble Fas Ligand protein; APTL protein; sFASL protein
 Product Gene Name   

FasL recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Region of FasL protein correspond ing to amino acids HHHHHHHHPS PPPEKKELRK VAHLTGKSNS RSMPLEWEDT YGIVLLSGVK YKKGGLVINE TGLYFVYSKV YFRGQSCNNL PLSHKVYMRN SKYPQDLVMM EGKMMSYCTT GQMWARSSYL GAVFNLTSAD HLYVNVSELS LVNFEESQTF FGLYKL.
 OMIM    134638
 3D Structure    ModBase 3D Structure for P48023
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 Host    Human
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 Purity/Purification    > 98% by SDS-PAGE gel and HPLC Analyses.
 Form/Format    Sterile filtered through a 0.2 micron filter. Lyophilized from 1 x PBS, pH 7.2. Reconsitute in water to a concentration of 0.1-1.0 mg/ml
 Concentration    10ug per vial (lot specific)
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 Protein Type    Recombinant
 Biological Significance    Fas and Fas Ligand (FasL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active caspases then cleave various cellular substrates leading to the eventual cell death. sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL. The full length Fas (receptor) is a 319 amino acid type I transmembrane protein, which contains a 157 amino acid extracellular domain, a 17 amino acid transmembrane domain, and 145 amino acid cytoplasmic domain.
 Bioactivity    Determined by it's ability to induce cytotoxicity in Jurkat cells in the absence of any cross-linking. The ED50 for this effect is approximately 10.0 ng/ml, corresponding to a specific activity of approximately 1 x 10^5 units/mg.
 Endotoxin Levels    Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
 Expression System    CHO cells
 Biohazard    Use standard laboratory precautions when handling this material.
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 Preparation and Storage    Ships ambient or refrigerated. Upon receipt store at 4 degree C short term, -20 degree C long term. After reconsituted, the solution can be stored at 4 degree C for up to 1 week. Working aliquots stored with a carrier protein are stable for at least 12 months at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of FasL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for FasL recombinant protein

   Purified soluble Human FasL protein
 Product Categories/Family for FasL recombinant protein    Cancer
 Applications Tested/Suitable for FasL recombinant protein   

User optimized

 Application Notes for FasL recombinant protein    Specific activity is > 2 x 10^5 units/mg
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NCBI/Uniprot data below describe general gene information for FasL. It may not necessarily be applicable to this product.
 NCBI GI #    28569614
 NCBI GeneID    356
 NCBI Accession #    AAO43991.1 [Other Products]
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 UniProt Primary Accession #    P48023 [Other Products]
 UniProt Secondary Accession #    Q9BZP9 [Other Products]
 UniProt Related Accession #    P48023 [Other Products]
 Molecular Weight    17.6 kDa
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 NCBI Official Full Name    Fas ligand
 NCBI Official Synonym Full Names    Fas ligand (TNF superfamily, member 6)
 NCBI Official Symbol    FASLG [Similar Products]
 NCBI Official Synonym Symbols   
APTL; FASL; CD178; CD95L; ALPS1B; CD95-L; TNFSF6; APT1LG1
[Similar Products]
 NCBI Protein Information    tumor necrosis factor ligand superfamily member 6
 UniProt Protein Name    Tumor necrosis factor ligand superfamily member 6
 UniProt Synonym Protein Names   
Apoptosis antigen ligand; APTL
 UniProt Gene Name    FASLG [Similar Products]
 UniProt Synonym Gene Names    APT1LG1; CD95L; FASL; TNFSF6; APTL; CD95-L; Fas ligand; FasL; sFasL; APL; FasL ICD; SPA [Similar Products]
 UniProt Entry Name    TNFL6_HUMAN
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 NCBI Summary for FasL    This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]
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 UniProt Comments for FasL    FasL: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. Homotrimer (Probable). Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: lysosomal lumen; extracellular space; integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane; extracellular region; caveola; nucleus; external side of plasma membrane

Molecular Function: protein binding; death receptor binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: caspase activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; apoptosis; positive regulation of apoptosis; response to lipopolysaccharide; negative regulation of transcription from RNA polymerase II promoter; signal transduction; cellular chloride ion homeostasis; endosomal lumen acidification; inflammatory cell apoptosis; negative regulation of angiogenesis; induction of apoptosis via death domain receptors; cell-cell signaling; positive regulation of neuron apoptosis; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of cell proliferation; retinal cell programmed cell death; immune response

Disease: Lung Cancer; Autoimmune Lymphoproliferative Syndrome
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 Research Articles on FasL    1. FAS A-670G polymorphism is associated with a higher risk for Pre-eclampsia (PE). There was no association between FAS Ligand C-844T polymorphism and PE.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FasL recombinant proteinPathways associated with FasL recombinant protein
 Reference Product  PubMed Publications
 FAS recombinant protein  >3618 publications with FasL and FAS
 CASP8 recombinant protein  >411 publications with FasL and CASP8
 JUN recombinant protein  >405 publications with FasL and JUN
 FADD recombinant protein  >202 publications with FasL and FADD
 CFLAR recombinant protein  >85 publications with FasL and CFLAR
 BID recombinant protein  >60 publications with FasL and BID
 CASP10 recombinant protein  >21 publications with FasL and CASP10
 TNFRSF6B recombinant protein  >21 publications with FasL and TNFRSF6B
 MAPK8 recombinant protein  >11 publications with FasL and MAPK8
 FYN recombinant protein  >6 publications with FasL and FYN
 Products by Pathway  Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
Diseases associated with FasL recombinant proteinOrgans/Tissues associated with FasL recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >984 publications with FasL and Necrosis
 Inflammation Antibodies  >240 publications with FasL and Inflammation
 Liver Diseases Antibodies  >219 publications with FasL and Liver Diseases
 Nervous System Diseases Antibodies  >167 publications with FasL and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >140 publications with FasL and Cardiovascular Diseases
 Hepatitis Antibodies  >130 publications with FasL and Hepatitis
 Breast Neoplasms Antibodies  >94 publications with FasL and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >93 publications with FasL and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >88 publications with FasL and Lung Neoplasms
 Melanoma Antibodies  >79 publications with FasL and Melanoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1788 publications with FasL and Blood
 Bone Marrow Antibodies  >119 publications with FasL and Bone Marrow
 Intestine Antibodies  >63 publications with FasL and Intestine
 Prostate Antibodies  >60 publications with FasL and Prostate
 Uterus Antibodies  >54 publications with FasL and Uterus
 Spleen Antibodies  >54 publications with FasL and Spleen
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